ATOH7
- Known as:
- ATOH7
- Catalog number:
- 002158A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATOH7
Related genes to: ATOH7
- Gene:
- ATOH7 NIH gene
- Name:
- atonal bHLH transcription factor 7
- Previous symbol:
- -
- Synonyms:
- Math5, bHLHa13
- Chromosome:
- 10q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-05
- Date modifiied:
- 2016-10-05
Related products to: ATOH7
Related articles to: ATOH7
- Retinal development is orchestrated by a network of transcription factors that guide multipotent retinal progenitor cells (RPCs) to fate-committed lineages, ultimately producing seven major retinal cell classes. Among these, retinal ganglion cells (RGCs) serve as the sole output neurons of the retina, relaying visual and non-visual information to the brain. RGC specification requires a cascade of transcriptional regulators, including the basic helix-loop-helix (bHLH) factor Atoh7, which confers competence to RPCs, and Pou4f2 and Isl1, which drive terminal differentiation and subtype diversification. Previous studies demonstrate that the SoxC group transcription factors (Sox4, Sox11, and Sox12) are also involved in RGC genesis, but their precise integration into the Atoh7-driven regulatory hierarchy remains undefined. To address this question, we used the retina-specific Vsx2-Cre line to generate Sox4/Sox11 double conditional knockout (dcKO) and Sox4/Sox11/Atoh7 triple knockout (tKO) mice. Immunohistochemistry revealed profound lineage disruption and reduced progenitor proliferation and survival in both dcKO and tKO retinas; not only RGC genesis but also that of horizontal and amacrine (H&As) cells were severely compromised, whereas photoreceptor cells (PHCs) production increased. These results indicate that Sox4 and Sox11 are involved in the coordinated generation of the different early retinal lineages. Like the Atoh7-null retina, RGC precursors still formed in the SoxC dcKO retina, but their genesis was almost completely abolished in the tKO retina. Our findings indicate that the SoxC factors act in parallel with Atoh7 as a major upstream regulatory input to initiate RGC fate. Bulk RNA-seq revealed the SoxC-dependent transcriptional programs and signaling pathways and confirmed the lineage changes demonstrated by marker analysis. CUT&Tag analysis identified the genome-wide binding sites and thereby the target genes of Sox11, further illuminating the mechanisms underlying functions of the SoxC factors in multiple retinal cell states/types during development. - Source: PubMed
Publication date: 2026/07/27
Enriquez SandyGe YichenNan NanLefebvre VeroniqueLiu TaoMu Xiuqian - Atoh7 is a transiently expressed developmental transcription factor that contributes to the generation of all seven major retinal cell types. Despite this broad lineage potential, Atoh7 is specifically required for retinal ganglion cell (RGC) formation and survival. In mice, a substantial proportion of RGCs arise from Atoh7-negative progenitors, suggesting potential nonautonomous roles for Atoh7 in RGC development. Although atoh7 function is conserved in zebrafish, the complete lineage, including the contribution to the RGC population, has not been fully defined. Here, we sought to determine the atoh7 retinal lineage in wild type and atoh7 mutant zebrafish. - Source: PubMed
Bennett Darby MNewland Robert IVeldman Matthew BMiesfeld Joel B - The aim of this study was to gain insight into the molecular spectrum of anophthalmia and microphthalmia (A/M) in the Egyptian population. - Source: PubMed
Publication date: 2026/01/20
Elmakkawy GehadNabil AmiraNabil KarimAmin Asmaa KenawyMaskill DavidAli ManirSchorderet DanielBayoumi NaderShakankiri NihalAbdalla Ebtesam - While a few studies have reported on single nucleotide polymorphisms associated with glaucoma in the Korean population, comprehensive data on genotype-phenotype correlations across multiple candidate genes are lacking. This study aimed to investigate the associations of variants in 10 candidate genes (CDKN2B, SIX1, SIX6, SCYL1, CHEK2, ATOH7, DCLK1, RERE, CDC7, and CARD10) with primary open-angle glaucoma (POAG) susceptibility and structural phenotypic features. We employed a 2-stage study design consisting of a discovery phase (targeted sequencing of 100 subjects) and a confirmation phase (genotyping of 24 selected variants in a total cohort of 382 subjects: 160 POAG cases and 222 controls). Associations with POAG risk and structural parameters, including vertical cup-to-disc ratio and retinal nerve fiber layer thickness (RNFLT), were analyzed using multivariable logistic regression and analysis of variance. The Benjamini-Hochberg false discovery rate method was applied to account for multiple testing. Regarding POAG susceptibility, 3 variants in DCLK1, SIX6, and SCYL1 showed nominal significance in the initial analysis but did not withstand false discovery rate correction. However, regarding phenotypic traits, rs33912345 in SIX6 demonstrated robust significant associations with both increased vertical cup-to-disc ratio and reduced average, superior, temporal and inferior RNFLT. Additionally, rs748189671 in RERE was significantly associated with temporal RNFLT. In detailed clock-hour analysis, variants in DCLK1 and SIX1 also showed significant correlations with 3 o'clock sector of RNFLT. Our findings identify DCLK1, SIX1, SIX6 and RERE as key genetic factors influencing optic nerve morphology and RNFLT in the Korean population. These results suggest that these genes may primarily modulate the structural vulnerability of the optic nerve, highlighting their potential utility for phenotypic profiling of glaucoma in the Korean population. However, these results are exploratory, and further large-scale studies are warranted to validate these associations and elucidate their clinical implications in glaucoma genetics. - Source: PubMed
Seol Bo RamJeoung Jin Wook - is a transiently expressed developmental transcription factor that gives rise to the seven major retinal cell types. Despite this broad lineage, is only required for retinal ganglion cell (RGC) genesis and survival, even though a significant portion of RGCs are negative based on lineage tracing in mice, suggesting a cell nonautonomous role for in the genesis and survival of all RGCs. Atoh7 function is conserved in zebrafish, yet the full retinal lineage, including the RGC population, has remained unidentified. Therefore, we sought to determine the retinal lineage in wild type and mutant zebrafish retinas. - Source: PubMed
Publication date: 2026/03/22
Bennett Darby MNewland Robert IVeldman Matthew BMiesfeld Joel B