ATG10
- Known as:
- ATG10
- Catalog number:
- 002144A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATG10
Related genes to: ATG10
- Gene:
- ATG10 NIH gene
- Name:
- autophagy related 10
- Previous symbol:
- APG10L
- Synonyms:
- DKFZP586I0418, FLJ13954
- Chromosome:
- 5q14.1-q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-28
- Date modifiied:
- 2018-02-13
Related products to: ATG10
Related articles to: ATG10
- The stony coral, Acropora tenuis, possesses progenitor/undifferentiated cells similar to other anthozoans; however, their developmental potential and fate remain obscure. The present study initially showed that nerve progenitors and undifferentiated-like cells were both tagged with histone H3 trimethylation at Lys 4 and Lys 27, suggesting that Acropora progenitor/undifferentiated cells might be multipotent. A rabbit anti-reverse transcriptase (anti-AtRTase) antibody recognized undifferentiated-like cells in the middle region of the ectodermal layer in embryos 60-85 h post-fertilization. At the larval stages, AtRTase signals were concentrated around the oral pole where the larval ectoderm invaginated to form the pharyngeal stomodeum. Undifferentiated-like cells, but not the apical-most glandular epithelium in the ectoderm, appeared to enter the pharynx. Consistent with this hypothesis, AtRTase signals were continuous from undifferentiated-like cells to the stomodeum. Nerve progenitors (neuroblasts) expressed nerve-specific tubulin beta-III (TUBB3). They differentiated into nerve cells and expressed a neuroblast differentiation-associated protein around the aboral pole of larvae. On the other hand, non-aboral neuroblasts expressed the autophagy-related protein 10 in addition to TUBB3 and developed into vacuolated hyaline cells (VHCs) that penetrated through the ectoderm apicobasally. The present study suggests strongly that ectodermal undifferentiated cells in A. tenuis have the potential to form the stomodeum. In contrast, nerve progenitors possess the dual potential to differentiate into nerve cells and VHCs, which appears to depend on aboral and non-aboral positions. - Source: PubMed
Kawamura KazSekida SatokoSatoh Noriyuki - : This study assessed the impact of variations in autophagy-related genes () on baseline characteristics of cutaneous melanoma, laboratory parameters (including inflammatory biomarkers), response to therapy, and survival in patients treated with immune checkpoint inhibitors (ICIs) as first-line therapy. : DNA was extracted from blood samples of 144 melanoma patients. Genotyping of (rs2245214 and rs510432), (rs1864183 and rs1864182), and (rs2241880) was performed using an allelic discrimination method on the StepOnePlus Real-Time PCR System. Correlations with laboratory parameters, response to therapy, and survival were assessed only in the subgroup of patients who received ICIs in first-line treatment ( = 74). Statistical significance was calculated, and values were adjusted for multiple testing using the Benjamini-Hochberg False Discovery Rate (FDR). : Considering baseline characteristics of 144 patients, rs2245214 showed a trend with regression ( = 0.042) and lymphovascular invasion ( = 0.05), while rs2241880 was associated with lymphovascular invasion ( = 0.056), with corrected FDR q value for all histopathological characteristics of 0.076. In patients who received ICIs in first-line, rs2245214 genotypes were associated with LDH ( = 0.001, q = 0.004) and the number of metastatic sites ( < 0.001, q = 0.004). Also, rs2245214 was associated with neutrophil-to-lymphocyte ratio (NLR) ( = 0.036, q = 0.045) systemic immune-inflammation (SII) index ( = 0.038, q = 0.048) and pan-immune-inflammation value (PIV) ( = 0.031,q = 0.041), while rs1864183 was associated with PIV ( = 0.047, q = 0.047). The association of genotypes with disease control rate (DCR) was demonstrated for rs2245214 ( = 0.013, q = 0.029) and rs2241880 ( = 0.032,q = 0.032). Progression-free survival (PFS) was significantly associated with rs1864183 ( = 0.023, q = 0.046). The significance of the rs1864183 C/T genotype as a prognostic marker for progression was confirmed in both univariate and multivariate Cox proportional hazards regression analyses ( = 0.025, q = 0.028 and = 0.022, respectively). : This study shows that rs2245214, rs1864183, and rs2241880 correlate with systemic inflammation, response to ICIs, and had a trend toward melanoma characteristics. However, these findings should be confirmed in larger patient cohorts. - Source: PubMed
Publication date: 2026/08/21
Ćućuz Jokić MilicaCikota-Aleksić BojanaPavlica JovanaDujović BrankoSalatić IgorStanojković TijanaBollhorn TatjanaKandolf Lidija - Red light accelerates tomato fruit ripening, but the molecular link between light signalling and autophagy remains unclear. Here, we show that red light promotes fruit coloration by activating autophagy in tomato pericarp. This response largely depends on the transcription factor HY5, which positively regulates this process by directly activating ATG10 expression. ATG10 overexpression rescues the autophagic activity and the delayed coloration of hy5 mutants. Thus, the HY5-ATG10 module links red light to autophagy and fruit maturation, suggesting a target for improving fruit colour. - Source: PubMed
Publication date: 2026/07/29
Guo YeBao ZhiruHuo YawenHu RanCao SaiyuWang Pengwei - Obsessive-compulsive disorder (OCD) remains difficult to treat in a substantial minority of patients, despite the established first-line use of exposure and response prevention, selective serotonin reuptake inhibitors, and pharmacological augmentation. This treatment gap has encouraged renewed interest in biological axes that sit outside a narrow monoamine-centered model. In this study, we asked whether transcriptional genetic signals for OCD show enrichment in cellular maintenance pathways motivated by nicotinamide mononucleotide (NMN)-associated aging biology and whether any such pathways outperform a curated antidepressant-related gene comparator. Using OCD transcriptome-wide association study (TWAS)-derived gene-level Z statistics and an absolute Z-score ranking framework, ten NMN-motivated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway expansions were compared against AntiDep_Genes. The strongest and most defensible finding in the OCD analysis was selective enrichment of KEGG_AUTOPHAGY_ANIMAL. Autophagy nominally outperformed the antidepressant comparator in the primary head-to-head test, with normalized enrichment score (NES) = 1.166, p = 0.041979, and difference in normalized enrichment score (dNES) = +0.2097. The signal persisted after removal of overlapping antidepressant-related genes, with cleaned NES = 1.1784 and p = 0.042479, and the autophagy set also showed a higher absolute Z-score distribution than AntiDep_Genes by Mann-Whitney U testing, p = 0.04717. Leading-edge overlap with the antidepressant comparator was minimal, limited to mechanistic target of rapamycin (MTOR). The OCD autophagy signal was driven by a mixture of core autophagy machinery and upstream signaling genes, including MAPK3, MAP1LC3A, PPP2CB, MAP2K1, GORASP2, BAD, ATG2A, ATG10, MAPK8, and CALCOCO2. This pattern suggests a signaling-execution module rather than a simple enrichment of canonical ATG genes alone. The result is biologically consistent with recent OCD genetic findings implicating cortical and hippocampal excitatory neurons and D1/D2 striatal medium spiny neurons, which are cell types with high synaptic and metabolic demands. These findings are best viewed as hypothesis-generating. They do not support NMN, nicotinamide adenine dinucleotide (NAD+) precursors, or autophagy modulators as OCD treatments, but they do identify autophagy and mitochondrial quality-control biology as plausible targets for future functional and stratification studies. The autophagy enrichment was nominally significant in the primary analysis but did not survive Benjamini-Hochberg false-discovery rate correction across the ten tested pathways (false discovery rate (FDR)-adjusted p = 0.41979); the findings should therefore be considered hypothesis-generating. - Source: PubMed
Publication date: 2026/07/24
Cheung Ngo - [This corrects the article on p. 1188 in vol. 13, PMID: 37168332.]. - Source: PubMed
Publication date: 2026/06/15
Li FengLi KaiLi DanZhang WeiYang Kong-WuKe DiGuo QiangShi Rong-Shu