ATF3
- Known as:
- ATF3
- Catalog number:
- 002120A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ATF3
Related genes to: ATF3
- Gene:
- ATF3 NIH gene
- Name:
- activating transcription factor 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-08-03
- Date modifiied:
- 2014-11-19
Related products to: ATF3
Related articles to: ATF3
- Hepatocyte ballooning is a defining histological marker of progressive steatohepatitis, but its molecular basis remains poorly defined. - Source: PubMed
Publication date: 2026/09/12
Ganguly DebopriyoMondal BandanaDas SubhasDey IndrashishMandal AyanGhosh TrinathDeo MonalishaAhmed MisbaBanerjee SomaChatterjee AnkitaBasu Priyadarshi - Amyloid-beta (Aβ)-induced microvascular injury is a key pathological feature of cerebral amyloid angiopathy (CAA). Recent evidence suggests that ferroptosis is implicated in Aβ pathology; however, its cell-type specificity and regulatory mechanisms within the cerebral microvasculature in CAA remain unclear. - Source: PubMed
Wu ChunmeiYe XiaodongChen HualinFang YongkangLan YanYe JiaheLiu XinXiao RuizhiZhu SuiqiangHuang Shanshan - Microglial neuroinflammation contributes to the progression of neurodegenerative diseases, yet it remains challenging to attenuate inflammatory responses while preserving cellular function. The effects of (R)-nicotine, diosmetin, their combined administration, and galantamine on heterogeneous BV2 transcriptional states have not been compared at single-cell resolution. - Source: PubMed
Publication date: 2026/09/01
Liu YihanYu HaoZhang JingbinLi XinMa YunuGuang ChunmeiMu WenjunChen HuanHou Hongwei - Repeated implantation failure (RIF) remains a significant challenge in assisted reproductive technology. Endometrial receptivity (ER) plays a critical role in embryo implantation. However, the impact of advanced maternal age (AMA) on ER in this population remains unclear. The study aimed to evaluate whether maternal age is associated with displacement of the window of implantation (WOI) and explore potential endometrial transcriptomic characteristics. - Source: PubMed
Publication date: 2026/08/26
Guo YapingZhang MianqiuWu ZhenggangHou XiaojingZhang JuanYang XiaoxuanDing HuiJi ChenboLing XiufengSu YanShen Rong - Osteosarcoma (OS) is highly invasive, metastatic, and lacks effective therapies, leading to poor prognosis. This study aims to dissect the core epigenetic features of OS from the perspective of chromatin accessibility to elucidate its pathogenesis and identify novel therapeutic targets. ATAC-seq was used to map the global chromatin accessibility profiles of OS tissues versus normal controls. We identified OS-specific aberrantly accessible chromatin regions and delineated enriched transcription factor binding motifs. Key transcription factors were validated by Western blotting and flow cytometry. Notably, in regions with enhanced accessibility, the binding probability of AP-1 family members (including Atf3, Fra1, Fra2, JunB, BATF, AP-1, Jun-AP1, Bach2, and CTCF) was significantly elevated. Further analysis indicates that JunB can inhibit apoptosis of OS cells and enhance their invasive ability, suggesting that it may be related to tumor progression. Overall, JunB, as a candidate molecule with potential research value, is worthy of further verification in subsequent in vivo models and clinical samples to determine its feasibility as an intervention target for OS. - Source: PubMed
Publication date: 2026/09/05
Ye FanHu Po