ARHGDIA
- Known as:
- ARHGDIA
- Catalog number:
- 001886A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ARHGDIA
Related genes to: ARHGDIA
- Gene:
- ARHGDIA NIH gene
- Name:
- Rho GDP dissociation inhibitor alpha
- Previous symbol:
- GDIA1
- Synonyms:
- RHOGDI
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-30
- Date modifiied:
- 2018-03-20
Related products to: ARHGDIA
Related articles to: ARHGDIA
- Epigenetic markers, particularly DNA methylation, are promising tools for monitoring athlete health and training due to their role in cellular regulation, exercise responsiveness and molecular stability. However, exercise-induced epigenetic changes in peripheral blood in trained individuals remain unexplored. Therefore, we investigated the whole blood DNA methylation responses to swimming performed in the moderate (below critical speed) and severe (above critical speed) intensity domains using minimally invasive sampling. Ten high-performance swimmers (5 males, 5 females; age 16-24 years) completed a 12 × 25 m maximal effort trial to determine critical swimming speed. One week later, participants performed two separate trials in the moderate and severe domains. Capillary blood (1 mL) was collected pre- and post-exercise for DNA methylation profiling via reduced representation bisulfite sequencing. Global methylation and differentially methylated loci (DMLs) and regions (DMRs) were assessed using logistic regression. Exercise induced global hypomethylation regardless of intensity (severe domain: 0.25% difference; 95% CI: 0.023, 0.372; P = 0.030; moderate domain: 0.17% difference; 95% CI: 0.012, 0.306; P = 0.037). In contrast, DMLs and DMRs were largely intensity-specific, with <10% of DMLs and no DMRs shared between domains. Promoter DMRs were identified in immune-related genes: ARHGDIA (-13.5% in the severe domain) and RNF7 (+20.6% in the moderate domain). Although global methylation patterns were consistent between swimming trials, exercise intensity-specific DNA methylation signatures were detectable from capillary blood samples. These results highlight the potential of epigenetic profiling for personalised monitoring of training responses and athlete health. - Source: PubMed
Publication date: 2026/06/12
Goldsmith C DLawler N GPyne D BKozlovskaia MMcGibbon KMitchell L J GGovus A D - The global incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rising alongside epidemics of diabetes and obesity. Rho GDP-dissociation inhibitor (RhoGDI) is now recognized to play dual regulatory roles in disease. A deeper understanding of its mechanistic contributions in MASLD could offer critical insights for developing novel therapies against this growing health burden. Immunohistochemical staining was used to examine RhoGDI expression in liver tissues from patients with MASLD. Hepatocyte-specific deletion of Arhgdia (the gene encodes RhoGDI) was generated in mice, and they subjected to NASH diets to induce hepatic steatosis. Transcriptomic sequencing was carried out to identify altered pathways in the Arhgdia-deficient mice, followed by functional investigations of downstream signaling and mitochondrial performance. Finally, the therapeutic potential of a candidate compound was evaluated in the MASLD model. The expression level of RhoGDI was significantly upregulated, and hepatocyte-specific deletion of Arhgdia (the gene encodes RhoGDI) attenuated hepatic lipid accumulation and fibrotic progression. The RNA sequencing analysis revealed that RhoGDI deficiency suppressed the hepatic steroid hormone biosynthesis pathway. It was demonstrated that RhoGDI plays a crucial role in maintaining mitochondrial function, since hepatocyte-specific knockout of Arhgdia significantly reversed mitochondrial dysfunction in mice. Furthermore, a natural compound was found to alleviate hepatic steatosis and inflammation in MASLD mice by targeting RhoGDI. This finding demonstrates that Arhgdia deletion confers protection against the progression of MASLD by reducing hepatic lipid accumulation and enhances mitochondrial β-oxidation in hepatocytes establishing RhoGDI as a critical regulator of MASLD pathogenesis and highlighting its potential as a therapeutic target for metabolic liver diseases. - Source: PubMed
Publication date: 2026/01/23
Wang YongzhiZhou YuanqiXu YifanWang ChenMeng ShuoLi HonglinTang HuifangZhang Jian - Rhesus macaques (Macaca mulatta) are the most common non-human primates living in captivity. The use of rhesus macaques as model objects is determined, first of all, by their phylogenetic and physiological closeness to humans, and, as a consequence, the possibility of extrapolating the obtained results to humans. Currently, it is known that a number of biochemical changes occur under various physiological conditions, including at the transcriptomic level. The real-time polymerase chain reaction is a widely used universal method for gene expression analysis. Carrying out such studies always requires a preliminary selection of "housekeeping genes" (HKGs) - genes necessary for the implementation of basic functions in the cell and stably expressed in different cell types and under different conditions. At present, there are only two systematic studies on the search for HKGs in the rhesus macaque brain, and therefore in this work a search and systematization of HKGs for this species were carried out. As a result, two panels of promising HKGs for M. mulatta were formed: an extended panel, consisting of 56 genes, and a small panel, consisting of 8 genes: ARHGDIA, CYB5R1, NDUFA7, RRAGA, TTC1, UBA6, VPS72, and YWHAH. Both panels of potential HKGs do not have pseudogenes in macaques or humans, are characterized by stable and sufficient expression in the brain of rhesus macaques and can be used to analyze expression not only in the brain but also in peripheral blood. However, it should be noted that the data have not been experimentally verified and require verification in laboratory conditions. - Source: PubMed
Shulskaya M VAlieva A KhKumakov I RShadrina M ISlominsky P A - Demethylase fat mass and obesity-related protein (FTO), which belongs to the AlkB homologous (ABH) family, is associated with various neurological diseases, cancer, and obesity. This protein, which contains many structurally and functionally different regions, contains a COOH-terminal domain whose function, unlike other ABH members, is not fully understood. This study aimed to investigate the effects of the exonic V493F mutation in this region of FTO on the soluble proteome. - Source: PubMed
Kanli Aylin - The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibitors of the RhoA signaling pathway are limited in hypertension treatment, suffering from poor efficacy, insufficient specificity, and developmental challenges. - Source: PubMed
Publication date: 2025/06/16
Wang JiawenYuan ZhenYu NaJiao QianZhou HongleiLiao WenjieShan JiweiRuan ShanshanZhao YiMo YaQi LuyaoLi TiejunFu JianjunKe BowenXu YufangQian XuhongZhang JianZhao ZhenjiangLi ShiliangWang RuiLi Honglin