ARHGAP9
- Known as:
- ARHGAP9
- Catalog number:
- 001865A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ARHGAP9
Related genes to: ARHGAP9
- Gene:
- ARHGAP9 NIH gene
- Name:
- Rho GTPase activating protein 9
- Previous symbol:
- -
- Synonyms:
- MGC1295, 10C
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-28
- Date modifiied:
- 2014-11-19
Related products to: ARHGAP9
Related articles to: ARHGAP9
- Resistance to adjuvant chemotherapy following enucleation continues to drive recurrence and metastasis in high-risk advanced retinoblastoma (RB), posing a major clinical challenge. To identify candidate genes, a previous transcriptomic analysis revealed markedly reduced expression of Rho GTPase-activating protein 9 (ARHGAP9) in the etoposide-resistant Y79/EDR cell line. This study aims to further investigate the effect of ARHGAP9 on chemoresistance in high-risk advanced RB. - Source: PubMed
Song WenpingLi RuijieWu XuanCheng ChengZhang LiZhao JunyangYao HongjuanZhang ChengyueLi LiangLi Ding - Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality globally. Genomic susceptibility factors are acknowledged as critical modulators of disease variability and progression. The Sonic Hedgehog (SHH) pathway regulates epithelial tissue healing, mucin synthesis, and airway remodeling. GLI1 polymorphic variants may influence the manifestations of COPD. - Source: PubMed
Publication date: 2026/08/10
Mahajan NidhiChopra VishalGarg KrantiSharma Siddharth - We aim to investigate the molecular heterogeneity of Burkitt lymphoma (BL) by analyzing the impact of age and Epstein-Barr virus (EBV) infection on protein expression in tumor tissues. Using liquid chromatography-mass spectrometry (LC-MS), we performed proteomic analysis on 10 formalin-fixed paraffin-embedded (FFPE) BL tissue samples (5 adults, 5 pediatric; stratified by EBV status) alongside clinical data from 273 BL patients. Clinically, pediatric patients showed higher lactate dehydrogenase (LDH) levels and advanced tumor stages (P < 0.05), while EBV-positive cases exhibited unique metastatic potential. Key findings revealed significant age-related disparities: adult BL patients exhibited 343 differentially expressed proteins (208 up-regulated, 135 down-regulated) compared to pediatric cases, predominantly enriched in energy metabolism (e.g., PFKM, PGM2) and oxidative stress response pathways (e.g., SOD1, IDH1). EBV-positive BL demonstrated distinct molecular signatures, with 176 differentially expressed proteins (93 up-regulated, 83 down-regulated) linked to purine metabolism (e.g., IMPDH2), apoptosis (e.g., MAPK13, BID), autophagy pathway (e.g., ATG3) and cytoskeletal remodeling (e.g., ARHGAP9, SCRIB). Our results provide novel insights into BL pathogenesis, emphasizing the interplay of age and EBV in shaping molecular landscapes. This study underscores the need for multi-omics integration to advance precision therapy strategies for BL subtypes. - Source: PubMed
Publication date: 2025/11/19
Huang YuZheng ShuangHuang XinyiLi ShuqiZhang WenhuiShu ManCao Qinghua - The aim of this study was to find novel diagnostic markers for renal fibrosis based on bioinformatics analysis. - Source: PubMed
Publication date: 2025/11/10
Gao ChenPeng FenghuaXie XubiaoPeng Longkai - Sjögren's syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration and formation of lymphoepithelial lesions (LEL) in exocrine glands, leading to secretory dysfunction. DNA methylation, a dynamically regulated epigenetic mark, has been increasingly recognized as a key regulatory mechanism in the pathogenesis of autoimmune diseases including SS, and holds promise for identifying novel diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2025/10/27
Chi YantingQin ZhimingQiu JingjingLi Binbin