AQP12B
- Known as:
- AQP12B
- Catalog number:
- 001821A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AQP12B
Related genes to: AQP12B
- Gene:
- AQP12B NIH gene
- Name:
- aquaporin 12B
- Previous symbol:
- INSSA3
- Synonyms:
- -
- Chromosome:
- 2q37.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-03-29
- Date modifiied:
- 2015-09-10
Related products to: AQP12B
Related articles to: AQP12B
- Bladder cancer (BC) carries a substantial global burden. Although lead (Pb) exposure has been linked to cancer, its molecular impact on bladder tumors remains unclear. We asked whether Pb-responsive transcriptional programs are present and clinically relevant in BC by integrating toxicogenomic resources with tumor transcriptomes and whether a composite lead-response score has prognostic value. Differential expression was performed on TCGA bladder urothelial carcinoma (BLCA) RNA-seq data (tumor vs. normal). Lead-associated genes were curated from the Comparative Toxicogenomics Database (CTD) and tested for over-representation among BLCA differentially expressed genes (DEGs) using a hypergeometric framework, with a stricter |logFC| ≥ 1 sensitivity. A tumor-level lead-response score was derived from the Pb-DEG overlap. Associations with overall survival (OS) were assessed using Cox models adjusted for age, sex, and pathological stage; secondary endpoints included PFI/DFI/DSS. Lead-associated genes were significantly enriched among BLCA DEGs (background M = 20,530; K = 2618; n = 11,436; k = 1595; = 4.21 × 10), and enrichment persisted under |logFC| ≥ 1 (n = 4275; k = 698; = 9.86 × 10). Pathway over-representation highlighted synaptic/neuronal-like adhesion and transmission, MAPK-centered signaling, and cell-cycle control. Among top candidates, was independently prognostic for OS (HR per 1 SD increase = 0.76; 95% CI 0.63-0.92; = 0.0038; N = 404). The composite lead-response score showed a directionally protective but non-significant association in multivariable OS models (HR per 1 SD = 0.93; 95% CI 0.81-1.05; = 0.244), while median-split Kaplan-Meier (KM) curves separated ( = 0.045). : Lead-responsive transcriptional programs are detectable in BLCA and intersect adhesion, MAPK signaling, and cell-cycle pathways. emerges as a plausible prognostic marker, and a composite lead-response score warrants external validation for risk stratification and clinical translation. - Source: PubMed
Publication date: 2025/10/10
Öztan Gözdeİşsever Halimİşsever TuğçeŞahin Levent - The scenario of the fertile spermatozoa with high fertilizing capability is basically dependent on gene expression-based epididymal function. The current investigation aimed to declare the varied expression of different candidate genes (PLA2G4D, LCN15, CLUAP1, SPP1, AQP12B, DEFB110 and ESR1) relevant to spermatozoa features between the different epididymal segments in the mature dromedary camels (n = 30). Scrotal contents were collected post-slaughtering, during the breeding season and the epididymis was separated from the testicles and divided into three segments (caput, corpus and cauda) based on its morphology and anatomical characteristics. Epididymal spermatozoa were harvested from each epididymal portion and evaluated for motility, count, viability and morphology. Samples were grouped depending on their epididymal sperm cells features into high-fertile (n = 15) and low-fertile (n = 15) groups. The gene expression of the candidate genes was defined in the isolated RNA from each epididymal portion tissue. The segmental sperm motion and count were significantly (p < .05 and p < .01) higher in the three epididymal parts of high-fertile camels than the lower ones. There were some candidate genes markedly up-regulated in its expression in epididymal head of high-fertile camels (PLA2G4D and LCN15) and low fertile (CLUAP1), while others in the body region of the high-fertile group (SPP1, AQP12B and DEFB110). Nevertheless, ER1 did not differ in the expression among the epididymal segments. In conclusion, the variant expression patterns of these epididymal genes in relation to the regional spermatozoa features might suggest important roles of these genes in sperm maturation process in the epididymis and focusing more interest on their potential utility as markers for male camel fertility prediction. - Source: PubMed
Rashad Dina E MIbrahim SallyEl-Sokary Mohamed M MMahmoud Karima Gh MKandiel Mohamed M MAbou El-Roos Mahmoud E ASosa Gamal A M - Studying testicular genes' expression may give key insights into precise regulation of its functions that influence epididymal sperm quality. The current study aimed to investigate the abundance of candidate genes involved in the regulation of testicular functions specially those regulate sperm function (PLA2G4D, SPP1, and CLUAP1), testicular steroidogenic function (ESR1 and AR), materials transport (AQP12B and LCN15), and defense mechanisms (DEFB110, GPX5, SOCS3, and IL6). Therefore, blood samples and testes with epididymis were collected from mature middle-aged (5-10 years) dromedary camels (n = 45) directly prior and after their slaughtering, respectively, during breeding season. Sera were evaluated for testosterone level and testicular biometry was measured with caliper. The epididymal tail semen was evaluated manually. Samples were distinguished based on testosterone level, testicular biometry, as well as epididymal semen features into high and low fertile groups. Total RNA was isolated from testicular tissues and gene expression was done using Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Results revealed that testosterone levels were significantly (P < 0.005) higher in camels with good semen quality than those of low quality. There was a significant (P < 0.0001) increase in testicular weight, length, width, thickness, and volume in high fertile than low fertile camels. PLA2G4D, SPP1, CLUAP1, ESR1, AR, AQP12B, LCN15, DEFB110, GPX5, and SOCS3 genes were upregulated (P < 0.001), and IL6 gene was downregulated (P < 0.01) in the testes of high fertile camels compared to the low fertile one. Thus, it could be concluded that examined genes might be valuable monitors of testicular functional status and fertility in dromedary camels. - Source: PubMed
Rashad Dina E MIbrahim SallyEl-Sokary Mohamed M MMahmoud Karima Gh MAbou El-Roos Mahmoud E ASosa Gamal A MKandiel Mohamed M M - Aquaporins () are proteins with various functions related to proper cell function and early development in mammals. The aim of this study was to evaluate the presence of and determine their mRNA levels in the cumulus oocyte complex (COC) of four bovine breeds and in blastocysts of five bovine crosses. Grade I, II and III COCs were collected by ovum pick up from non-lactating heifers of the Brahaman, Holstein, Gir and Romosinuano breeds. Embryos were produced in vitro up to the blastocyst stage of the bovine ♀Gir × ♂Holstein, ♀Holstein × ♂Gir, ♀Brahman × ♂Holstein, ♀Holstein × ♂Brahman, and ♀Romosinuano × ♂Holstein crosses. mRNA expression of - was estimated in COC and embryos by real-time-PCR. The presence of the twelve in the COCs and bovine embryos was established. Additionally, significant differences were determined in the expression of and in COCs, as well as in transcripts levels of , and from bovine embryos. Gene expression of in COCs and bovine embryos is consistent with the previously described biological functions. This is the first report of in COC of Gir, Brahman, Holstein and Romosinuano and embryos of five crossbreeds between and . - Source: PubMed
Publication date: 2022/12/27
Petano-Duque Julieth MCastro-Vargas Rafael ECruz-Mendez Juan SLozano-Villegas Kelly JHerrera-Sánchez María PUribe-García Heinner FNaranjo-Gómez Juan SOtero-Arroyo Rafael JRondón-Barragán Iang S - Alterations in genes specifically expressed in the pancreas have been associated with chronic pancreatitis (CP). A significant percentage of patients with non-alcoholic CP, however, do not have mutations in known risk genes, suggesting the existence of further susceptibility genes. Four aquaporins are expressed in the exocrine pancreas: AQP1, AQP5, AQP8 and AQP12, the latter being found exclusively in this organ. Therefore, we investigated the two AQP12 genes, AQP12A and AQP12B, in CP patients. - Source: PubMed
Publication date: 2022/09/21
Eiseler KatharinaDropmann Lea MariaBugert PeterEwers MarenWitt Heiko