APBB1IP
- Known as:
- APBB1IP
- Catalog number:
- 001741A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- APBB1IP
Related genes to: APBB1IP
- Gene:
- APBB1IP NIH gene
- Name:
- amyloid beta precursor protein binding family B member 1 interacting protein
- Previous symbol:
- -
- Synonyms:
- INAG1, RIAM
- Chromosome:
- 10p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-07
- Date modifiied:
- 2016-01-21
Related products to: APBB1IP
Related articles to: APBB1IP
- The current study investigated the correlation between Transient Receptor Potential (TRP)-related Genes (TRGs), prognosis, and drug sensitivity in Osteosarcoma (OS). - Source: PubMed
Publication date: 2026/07/07
Li XiangmingZhang MinghangXu ZiyiWang WeizhengLi Penghui - Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the axial skeleton, characterized by immune microenvironment dysregulation and elevated cytokines like TNF-α and IL-17. Mitochondrial oxidative phosphorylation (OXPHOS), crucial for immune cell function and survival, is implicated in AS pathogenesis. This study explores OXPHOS-related mechanisms in AS, identifies key genes using machine learning, and highlights potential therapeutic targets for precision medicine. - Source: PubMed
Chen YulingXu YuanCao ShuangyanLv QingYe YuanchunGu Jieruo - Breast cancer, a major threat to women's health worldwide, has mechanisms of onset that remain unclear. Within the human lysosomal system, a class of enzymes known as cathepsins exhibit elevated expression levels in various malignant tumors, suggesting that they may play key roles in cancer progression. - Source: PubMed
Publication date: 2025/01/29
Zhou ShengyiSun YizhouZha WenzhangZhou Guangjun - Pediatric adrenocortical tumors (ACTs), rare conditions with uncertain prognoses, have high incidence in southern and southeastern Brazil. Pediatric ACTs are highly heterogeneous, so establishing prognostic markers for these tumors is challenging. We have conducted transcriptomic analysis on 14 pediatric ACT samples and compared cases with favorable and unfavorable clinical outcomes to identify prognostically significant genes. This comparison showed 1257 differentially expressed genes in favorable and unfavorable cases. Among these genes, 15 out of 60 hub genes were significantly associated with five-year event-free survival (EFS), and 10 had significant diagnostic value for predicting ACT outcomes in an independent microarray dataset of pediatric adrenocortical carcinomas (GSE76019). Overexpression of N4BP2, HSPB6, JUN, APBB1IP, STK17B, CSNK1D, and KDM3A was associated with poorer EFS, whereas lower expression of ISCU, PTPR, PRKAB2, CD48, PRF1, ITGAL, KLK15, and HIST1H3J was associated with worse outcomes. Collectively, these findings underscore the prognostic significance of these hub genes and suggest that they play a potential role in pediatric ACT progression and are useful predictors of clinical outcomes. - Source: PubMed
Publication date: 2024/10/15
Veronez Luciana ChainXavier Alcides Euzebio TavaresNagano Luiz FernandoCorrea Carolina Alves PereiraBorges Kleiton SilvaSantos PaulaBaroni MirellaSilva Queiroz Rosane de PaulaAntonini Sonir Roberto RauberYunes José AndresBrandalise Silvia ReginaMolina Carlos Augusto FernandesPinto Emilia ModoloValera Elvis TerciTone Luiz GonzagaScrideli Carlos Alberto - Despite progress, the molecular mechanisms underlying Kawasaki Disease (KD) and intravenous immunoglobulin's (IVIG) ability to mitigate the inflammatory process remain poorly understood. To characterize this condition, plasma proteomic profiles, flow cytometry, and gene expression of T cell subsets were investigated in longitudinal samples from KD patients and compared with two control groups. Systems-level analysis of samples in the acute phase revealed distinctive inflammatory features of KD, involving mainly Th-1 and Th-17 mediators and unveiled a potential disease severity signature. APBB1IP demonstrated an association with coronary artery involvement (CAI) and was significantly higher in CAI+ compared to CAI- patients. Integrative analysis revealed a transient reduction in CD4+ EM T cells and a comprehensive immune activation and exhaustion. Following treatment, Tregs at both frequency and gene expression levels revealed immune dynamics of recovery. Overall, our data provide insights into KD, which may offer valuable information on prognostic indicators and possible targets for novel treatments. - Source: PubMed
Publication date: 2024/08/24
Cotugno NicolaOlivieri GiulioPascucci Giuseppe RubensAmodio DonatoMorrocchi ElenaPighi ChiaraManno Emma ConcettaRotulo Gioacchino AndreaD'Anna CarolinaChinali MarcelloTarissi de Jacobis IsabellaBuonsenso DaniloVillani AlbertoRossi PaoloMarchesi AlessandraPalma Paolo