AP1S2
- Known as:
- AP1S2
- Catalog number:
- 001719A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AP1S2
Related genes to: AP1S2
- Gene:
- AP1S2 NIH gene
- Name:
- adaptor related protein complex 1 subunit sigma 2
- Previous symbol:
- MRX59, MRXS5, PGS
- Synonyms:
- SIGMA1B
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-01
- Date modifiied:
- 2018-04-23
Related products to: AP1S2
Related articles to: AP1S2
- Coffin-Siris syndrome (CSS) is an uncommon genetic condition that is generally associated with developmental delay, craniofacial dysmorphism, hypertrichosis, and hypoplasia or aplasia of the fifth digit. Genetic variations in genes that encode components of the SWI/SNF chromatin-remodeling complex, such as SMARCA4, are known to cause CSS with variable phenotype expression. The expanded use of genotype-first methods has contributed to the broadening of the awareness of non-classical presentations. - Source: PubMed
Publication date: 2026/02/25
Shah Swetang JitendraRavi UshaDattani Aahna VMariswamy Arun Kumar Abhishek Kumar - SRRM4 is an exclusively neural-expressed splicing-factor gene not yet associated with a monogenic condition. - Source: PubMed
Publication date: 2026/04/09
Harrer PhilipKittke VolkerSaparov AliceKnaus AlexejZeidler ShimrietSchot RachelKraft FlorianBegemann MatthiasKoudijs SuzannaSorrentino UgoZhao ChenDzinovic IvanaPavlov MartinGraf ElisabethStehr Antonia MKrawitz Peter MWilhelm ChristianBiskup SaskiaAlsalloum FahdBerweck SteffenWinkelmann JulianeOexle KonradKurth IngoKorenke G ChristophZech Michael - Lung cancer remains the leading cause of cancer mortality. The AP-1 adaptor complex, including AP1AR, AP1S1, AP1S2, AP1S3, AP1M1, AP1M2, AP1B1, and AP1G1, functions as a conserved hub of vesicular trafficking, selecting cargo and coordinating clathrin-mediated transport. By shaping receptor recycling, membrane composition, and signal duration, AP-1 influences core cancer phenotypes such as proliferation, migration, and therapy response. However, the family-level role of AP-1 adaptors in lung cancer is incompletely defined. We systematically profiled all eight AP-1 adaptor genes using multi-omics datasets, survival resources, pharmacogenomic panels, Human Protein Atlas data, pathway enrichment, and single-cell RNA sequencing with cell-cell communication modeling. was consistently upregulated in lung adenocarcinoma and independently associated with poorer overall survival. It was linked to cell-cycle progression, DNA replication checkpoints, hypoxia, and epithelial-to-mesenchymal transition (EMT). At single cell resolution, also regulate malignant epithelial and fibroblast cell types. Pseudotime analyses revealed progressive activation along proliferative and EMT axes, and CellChat modeling indicated enhanced stromal and epithelial signaling. and showed complementary roles, associated with oncogenic/inflammatory signaling and immune-metabolic programs, respectively. These findings identify as a clinically relevant biomarker and highlight AP-1 adaptor biology as an underexplored contributor to lung adenocarcinoma progression and therapeutic stratification. - Source: PubMed
Publication date: 2026/01/01
Solomon Dahlak DanielYeh I-JengLiu Hsin-LiangSu Che-YuLee Yung-KuoKo Ching-ChungLin Hui-RuKumar SachinXuan Do Thi MinhPalekkode NeethuFathima AymanLin Hung-YunWang Chih-YangYen Meng-Chi - One serious consequence of diabetes mellitus is diabetic retinopathy (DR), which impairs eyesight to the point of blindness. While glucocorticoid medications are commonly employed in the management of DR, their therapeutic efficacy requires enhancement. Due to the tight association between glucocorticoid-related genes and the onset and development of DR, a comprehensive examination of its root cause of activity may be able to overcome the drawbacks of existing treatment approaches. - Source: PubMed
Publication date: 2025/11/06
Wang LingdaZhang RongWang LinWang YongruiZhang XiaodanZhou Guohong - Diabetic kidney disease (DKD) is a common and serious complication of diabetes mellitus, marked by a multifactorial pathogenesis and the absence of sensitive diagnostic biomarkers. Identifying novel molecular targets and therapeutic options is essential to improve early diagnosis and treatment outcomes. - Source: PubMed
Publication date: 2025/10/21
Liu YiWang Yu