ANGPTL1
- Known as:
- ANGPTL1
- Catalog number:
- 001568A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ANGPTL1
Related genes to: ANGPTL1
- Gene:
- ANGPTL1 NIH gene
- Name:
- angiopoietin like 1
- Previous symbol:
- ANGPT3
- Synonyms:
- ANG3, AngY, ARP1
- Chromosome:
- 1q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-02-07
- Date modifiied:
- 2015-11-11
Related products to: ANGPTL1
Related articles to: ANGPTL1
- Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening zoonotic viral disease characterized by endothelial dysfunction, coagulopathy, and systemic inflammation. Angiopoietin-like proteins (ANGPTLs) regulate vascular integrity, lipid metabolism, and inflammatory responses; however, their roles in the pathogenesis of CCHF remain unclear. In this prospective case-control study, serum levels of ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, and ANGPTL8 were measured by enzyme-linked immunosorbent assay (ELISA) in 60 patients with laboratory-confirmed CCHF and 30 healthy controls. Standard laboratory parameters were recorded, and correlations between ANGPTLs and inflammatory, coagulation, and metabolic markers were analyzed. Receiver operating characteristic (ROC) analysis was performed to assess diagnostic performance and exploratory mortality-discrimination ability. All measured ANGPTL levels were significantly lower in CCHF patients than in healthy controls. However, no statistically significant differences in ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL6, or ANGPTL8 levels were observed between survivors and non-survivors. Although ANGPTL2 and ANGPTL3 yielded statistically significant area under the curve (AUC) values for mortality, the small number of fatal cases limits the strength of this finding. Overall, reduced ANGPTL levels were associated with disease-related inflammatory, endothelial, coagulation-related, and metabolic alterations, but these findings do not support their role as prognostic markers for mortality or establish a causal role in CCHF pathogenesis. - Source: PubMed
Yeşildağ SümeyyeBüyüktuna Seyit AliÖksüz CanerDoğan Halef Okan - Posttransplant diabetes mellitus is a chronic metabolic complication that often develops in kidney transplant recipients and is an inflammatory disease that directly affects a patient's immune system. Angiopoietin and angiopoietin -like proteins are intrinsic mediators of immune cells. We assessed the relationship between circulating angiopoietin proteins ANGPT ¹ and ANGPT ²and angiopoietin-like proteins ANGPTL ³, ANGPTL ⁴, ANGPTL ⁶, ANGPTL ⁷, and ANGPTL ⁸ in kidney transplant recipients who develop posttransplant diabetes mellitus (experimental group) versus recipients who do not develop diabetes after transplant (control group). - Source: PubMed
Jahromi MohamedAl-Otaibi TorkiOthman NashwaMahmoud TarekNair ParasadA-Halim MedhatJahrami KawtharGheith Osama - This study investigated whether different pacing patterns during high-intensity exercise elicit distinct transcriptional responses in equine skeletal muscle. Eight Thoroughbred horses completed two treadmill exercise sessions in a randomized crossover design. In the positive-pacing condition, horses exercised at 110% maximal O2 uptake (V̇O2max) for 1 min followed by 90% V̇O2max for 1 min, whereas in the negative-pacing condition, the order was reversed. At 4 h after exercise, the positive-pacing protocol resulted in upregulation of 1989 genes and downregulation of 840 genes, whereas the negative-pacing protocol resulted in upregulation of 1710 genes and downregulation of 593 genes (false discovery rate <0.05; fold change ≥1.5). Despite these differences, most exercise-responsive genes and pathways related to hypoxia signaling, extracellular matrix remodeling, and metabolic regulation were shared between protocols. A direct comparison of gene expression between the two protocols identified four genes with higher expression after positive pacing, including RP1, MORN5, and two unannotated equine transcripts (ENSECAG00000060378 and ENSECAG00000057614), whereas five genes (OLFML2B, POSTN, ANGPTL1, MAP1A, and ZNF554) showed higher expression after negative pacing. These findings indicate that the skeletal muscle transcriptomic response to workload-matched high-intensity exercise is largely conserved between pacing strategies in Thoroughbred horses, with only limited pacing-dependent differences. - Source: PubMed
Publication date: 2026/07/17
Takahashi KenyaMukai KazutakaShirai TakanagaEbisuda YusakuSugiyama FumiYoshida ToshinobuHatta HideoKitaoka Yu - This study evaluates histomorphometric and immunohistochemical changes in the ex vivo trabecular meshwork (TM) of high-pressure glaucoma (HPG) and normal tension glaucoma (NTG) compared to controls from donor corneoscleral buttons. - Source: PubMed
Publication date: 2026/05/10
Rao AparnaMuduli Kalindi CSucharita Soumya - Gastric cancer (GC) remains one of the most common malignant tumors worldwide, with high incidence and mortality rates. Angiopoietin-like protein 1 (ANGPTL1), a member of the ANGPTL family, is known to function as an anti-angiogenic factor and tumor suppressor. However, its role and underlying mechanisms in GC development have not been investigated and require further investigation. Protein expression levels were analyzed using western blotting and immunofluorescence (IF) assays. Cell viability was assessed using the CCK-8 assay, and cell proliferation was evaluated through colony formation assays. Cell migration and invasion were examined using Transwell assays. Angiogenic capacity was determined through tube formation assays. The VEGFA mRNA expression was detected through RT-qPCR. The level of VEGFA was confirmed through ELISA. The tumor size, volume and weight were confirmed through the in vivo assay. The CD31 protein expression was verified though IHC assay. ANGPTL1 was found to be expressed at lower levels in GC cells, and negatively correlated with VEGFA. ANGPTL1 significantly inhibited GC cell proliferation, migration, and invasion. Furthermore, ANGPTL1 suppressed angiogenesis in vitro. Mechanistically, it was observed that ANGPTL1 overexpression reduced VEGFA expression, and ANGPTL1 can interact with VEGFA. Importantly, reintroduction of VEGFA reversed the inhibitory effects of ANGPTL1 on GC progression. Lastly, VEGFA overexpression retarded the tumor growth in vivo. This study demonstrates that ANGPTL1 inhibits the growth, migration, and angiogenesis of GC cells by downregulating VEGFA expression. These findings suggest that ANGPTL1 may serve as a promising therapeutic target for gastric cancer treatment. - Source: PubMed
Publication date: 2026/06/01
Jin LingliLu GuangxinShang RuiHu JunhuaZhu ChaobeiYan Tingting