ANGPT2
- Known as:
- ANGPT2
- Catalog number:
- 001566A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ANGPT2
Related genes to: ANGPT2
- Gene:
- ANGPT2 NIH gene
- Name:
- angiopoietin 2
- Previous symbol:
- -
- Synonyms:
- Ang2
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-10-05
Related products to: ANGPT2
Related articles to: ANGPT2
- Resistance to lenvatinib remains an important limitation in hepatocellular carcinoma treatment. Six patient-derived organoid lines were established and classified as sensitive or resistant according to ex vivo drug responses, retaining histological and immunophenotypic features of matched parental tumors. Resistant organoids showed unchanged ATP activity, whereas sensitive ones exhibited pronounced morphological changes and reduced ATP activity at higher concentrations. Transcriptome sequencing identified 408 upregulated and 269 downregulated genes in resistant versus sensitive organoids, with HIF-1 signaling among altered pathways. In resistant organoids, lenvatinib increased HIF-1α, ANGPT2, and HK3 mRNA, whereas comparable changes were not detected in sensitive organoids. KC7F2 reduced these transcripts and further decreased ATP activity when combined with lenvatinib. In organoid-derived xenografts, this combination suppressed tumor growth and HIF-1 target expression more than lenvatinib alone, indicating HIF-1 signaling contributes to the resistant phenotype and its inhibition may enhance response. - Source: PubMed
Publication date: 2026/09/04
Huang YongyeAi ZhuHuang Senmiao - Blood-brain barrier (BBB) disruption is a hallmark of acute traumatic brain injury (TBI), yet the immune-vascular mechanisms underlying endothelial dysfunction remain incompletely understood. Perivascular macrophages (PVMs) are strategically positioned to modulate cerebrovascular homeostasis, but their role in acute post-traumatic endothelial activation has not been systematically characterized. - Source: PubMed
Publication date: 2026/08/18
Lin YanyaLin ChengdaChen JianhuiChen ShijunHuang JianhuangHu Jianxiong - Although Dirofilaria repens induces perivascular proliferation in subcutaneous nodules, the molecular factors driving this angiogenic response remain unknown. The objective of this study is to investigate the activation of the angiogenic mechanism in an in vitro model of human vascular endothelial cells (HUVECs) stimulated with D. repens somatic antigen (DrSA) and Dr20/22 protein, identifying the key pathways underlying the vascular pathology caused by the parasite. - Source: PubMed
Publication date: 2026/08/20
Collado-Cuadrado ManuelMontero-Calle AnaVázquez-Ávila SaraBarderas RodrigoPękacz MateuszZawistowska-Deniziak AnnaSotillo JavierPericacho MiguelMorchón Rodrigo - Dirofilaria immitis infection induces endothelial inflammation and vascular remodeling, contributing to heartworm disease pathology. While excretory/secretory antigens (DiES) are known to promote angiogenesis, somatic antigens (DiSA) exhibit different modulatory effects. This study aims to characterize the differential angiogenic response of endothelial cells to these antigenic fractions using a proteomic approach. - Source: PubMed
Publication date: 2026/08/20
Collado-Cuadrado ManuelBalmori-de la Puente AlfonsoMontero-Calle AnaVázquez-Ávila SaraBarderas RodrigoSotillo JavierCarretón ElenaPericacho MiguelMorchón Rodrigo - Air pollution is a major environmental risk factor for Atrial Fibrillation (AF). We aimed to derive robust, pollutant-specific proteomic signatures to elucidate the biological mechanisms and evaluate their potential risk-stratification utility. - Source: PubMed
Publication date: 2026/08/17
Chen YuyuWu MinjiaLu ZhixiZheng LeiHe XiaoweiYao MinXu Cheng