ANGPT1
- Known as:
- ANGPT1
- Catalog number:
- 001565A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ANGPT1
Related genes to: ANGPT1
- Gene:
- ANGPT1 NIH gene
- Name:
- angiopoietin 1
- Previous symbol:
- -
- Synonyms:
- KIAA0003, Ang1
- Chromosome:
- 8q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-10
- Date modifiied:
- 2015-08-28
Related products to: ANGPT1
Related articles to: ANGPT1
- Lung cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for effective therapeutic agents. This study investigates the antitumor effects and underlying mechanisms of furmonertinib (FUR) in lung cancer cells. - Source: PubMed
Publication date: 2026/08/28
Wu FanJiao JieQiao MengTu Zhao Ri Ge - Abdominal cytoreductive surgery due to advanced-stage ovarian cancer (OC) often requires extensive fluid administration to stabilize hemodynamic conditions. Recently, systemic changes in the expression profile of Angiopoietin (ANG)/TIE axis genes have been demonstrated in those patients, raising the question whether they exhibit an inherent clinical phenotype associated with vascular dysfunction and leakage that may explain the significant perioperative fluid demands. Abdominal muscle tissue gene expression analysis as well as pre- and postoperative whole-body bioelectrical impedance analysis (BIA) in patients with OC (n = 20) and in control subjects (n = 16) were performed, and Total Body Water (TBW), Extracellular Water (ECW) and the ECW/TBW ratio were calculated. Intraoperative management comprised advanced hemodynamic monitoring and goal-directed therapy. Data are given as median values with interquartile range (IQR). Postoperative fluid balance normalized to duration of surgery was greater in OC group (11.2 (IQR 9.8-13.2) vs. 8.3 mL/min (6.3-10.8) in controls, p = 0.01), as was the maximum body weight-adjusted norepinephrine administration rate (p < 0.001), whereas the intraoperative fluid administration rate did not differ between groups (p = 0.29). Gene expression analysis revealed significantly increased ANG-2/1 and ANG-2/TIE2 expression ratios in peripheral muscle tissue from OC patients (p < 0.01), while additional markers of angiogenesis, endothelial activation, adhesion, and vascular barrier integrity showed no significant intergroup differences. ANG-2/1 gene expression ratio was significantly associated with postoperative fluid balance in the whole cohort (r = 0.54, p < 0.001). There were no pre- or postoperative intergroup differences in TBW, ECW and in the ECW/TBW ratio. However, intraoperative percentage increase in BIA parameters was significantly more pronounced in the OC group, compared to controls (TBW: 12.3 (9.9-14.6) vs. 8.1% (5.2-9.0), p < 0.001; ECW: 21.7 (17.1-25.9) vs. 15.5% (11.0-18.1), p < 0.001; ECW/TBW: 8.7 (7.7-10.4) vs. 6.9% (5.1-8.5), p = 0.006). Importantly, the relationships between perioperative fluid balance and changes in TBW, ECW and ECW/TBW ratio did not differ between groups (group × fluid balance interactions: p = 0.614, p = 0.511, and p = 0.545, respectively). In contrast, these BIA-derived changes increased progressively with longer duration of surgery in OC patients but not in controls, resulting in significant group × duration of surgery interactions (p = 0.030, p = 0.018, and p = 0.037, respectively). Patients with advanced-stage OC exhibited altered ANG/TIE gene-expression profiles, greater vasopressor requirements, and a distinct time-dependent pattern of perioperative body-water accumulation during cytoreductive surgery. However, BIA did not demonstrate a disproportionate increase in body water relative to positive fluid balance compared with controls. Thus, the observed alterations in ANG/TIE gene expression were not accompanied by a detectable systemic vascular leakage phenotype using BIA. - Source: PubMed
Publication date: 2026/09/01
Reifenhaeuser SarahStein KatrinFrede StillaEgger Eva KMustea AlexanderCoburn MarkKlaschik SvenSoehle MartinHilbert Tobias - - Source: PubMed
Publication date: 2026/09/01
Newman HaleyWong DerekSchubert JeffreyWu JinhuaSantana JuanLong ArielZhou ZiruiXu FengChen JianiTakeda MoeBrodersen Lisa EidenschinkBernt Kathrin MLuo MinjieTasian Sarah KLi Marilyn MZhong Yiming - Choroidal neovascularization (CNV) is a common and serious complication in various retinal diseases that involves the growth of new blood vessels from the choroid into the subretinal space, leading to a visual threat. Its underlying mechanism has not been fully uncovered. Discovering new genes related to CNV is an important way to reveal its molecular mechanisms. In this study, we used DisGeNET as the initial data source to identify genes related to CNV. The gene cluster method and additional screening tests were designed to explore the genetic landscape related to CNV. Our comprehensive analysis revealed many genes with high confidence, specifically identifying novel candidates that traditional topological methods missed. Notably, we identified SERPINE1, COL1A1, and ANGPT1 as unique gene signatures using our network embedding approach. Functionally, SERPINE1 regulates the plasminogen activation system to control proteolytic balance, COL1A1 maintains the structural integrity of the extracellular matrix during invasion, and ANGPT1 is critical for the maturation and stabilization of nascent vessels. Meanwhile, some genes were also identified by other methods, such as MMP2, a regulator of extracellular matrix degradation. The newly found genes are essential for understanding the process that initiates CNV. - Source: PubMed
Publication date: 2026/07/30
Liu LihuaZhang YuhangHuang FeimingBao YushengZhang Jian - This study proposed a non-invasive approach combining shear wave elastography (SWE) to measure junctional zone (JZ) stiffness and serum small extracellular vesicle (sEV) proteomics to explore molecular alterations in adenomyosis-associated infertility. - Source: PubMed
Publication date: 2026/08/18
Wang XialiDeng ShuangpingPan XiaopingLyu Guorong