AMY2B
- Known as:
- AMY2B
- Catalog number:
- 001547A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMY2B
Related genes to: AMY2B
- Gene:
- AMY2B NIH gene
- Name:
- amylase alpha 2B (pancreatic)
- Previous symbol:
- AMY2
- Synonyms:
- -
- Chromosome:
- 1p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-19
- Date modifiied:
- 2019-01-18
Related products to: AMY2B
Related articles to: AMY2B
- Hypertriglyceridemia arises from complex interactions between genetic and dietary factors. AMY1A/AMY2B copy number variation (CNV) and APOA5 rs651821 have been associated with triglyceride metabolism, and their effects may be modified by carbohydrate intake. This study investigated the combined influence of AMY1A/AMY2B CNV, APOA5 rs651821, and dietary carbohydrate intake on the odds of hypertriglyceridemia in middle-aged Korean adults. - Source: PubMed
Publication date: 2026/05/19
Kim MinyeongKo Seong-HeeKim SubinShin Dayeon - Chromosome instability (CIN) remains among the most important problems in modern cancer research. In this study, we conducted a genome-wide RNAi screen to identify genes that contribute to CIN. To achieve this, we used a human artificial chromosome in a novel sensitized screen to measure CIN. We screened 18,658 genes for their roles in maintaining chromosomal stability and identified 834 candidates as potential CIN genes. A secondary RNAi screen identified 44 genes with the most pronounced CIN phenotypes. In guilt-by-association analysis using a published set of 8,498 proteins across a panel of 949 cancer cell lines, this cohort of 44 genes displayed a striking correlation with mitotic regulators. Furthermore, altered expression of these proteins was associated with a poor prognosis across multiple cancer types. Specifically, downregulation of AMY2B, ALAD, PDGFRA, PPIE, VEZ1, and TTC19 is associated with poor survival in two or more of the following: small cell lung cancer, lung adenocarcinoma, adrenocortical carcinoma, ovarian cancer, and breast cancer. The genes identified in this screen hold potential as prognostic markers for patient survival across several cancer types and could potentially serve as targets for the development of new therapeutic approaches aimed at mitigating CIN. - Source: PubMed
Publication date: 2025/12/17
Liskovykh MikhailKochanova Natalia YChiang Chih-YuanDhall AnjaliAksenova VasilisaChen Yu-ChiReinhold William CDasso MaryThomas AnishCheng Ken Chih-ChienPommier YvesEarnshaw William CLarionov VladimirKouprina Natalay - People of South Asian (SA) origin have an elevated risk of cardiometabolic dysfunction and respond differentially to physical activity. Mechanisms underpinning these observations are incompletely understood. We investigated protein signatures of ethnicity, changing physical activity and their interaction. - Source: PubMed
Publication date: 2025/11/03
Henson JosephGhit AmrTziannou AikaterinaJames EmilyEdwardson Charlotte LBishop Nicolette CRazieh CameronJones Donald J LCao Thong HuyDavies Melanie JKhunti KamleshYates Thomas - Copy number variable (CNV) genes are important in evolution and disease, yet their sequence variation remains a blind spot in large-scale studies. We present ctyper, a method that leverages pangenomes to produce allele-specific copy numbers with locally phased variants from next-generation sequencing samples. Benchmarking on 3,351 CNV genes and 212 challenging medically relevant (CMR) genes, ctyper captures 96.5% of phased variants with ≥99.1% correctness of copy number in CNV genes and 94.8% of phased variants in CMR genes. Ctyper takes 1.5 h to genotype a genome on one CPU. The ctyper genotypes give a 4.81-fold improvement in predictions of gene expression compared to known expression quantitative trait locus (eQTL) variants. Allele-specific expression quantified divergent expression in 7.94% of paralogs and tissue-specific biases in 4.68%. We found reduced expression of SMN2 due to SMN1 conversion, potentially affecting spinal muscular atrophy, and increased expression of translocated duplications of AMY2B. Overall, ctyper enables biobank-scale genotyping of CNV and CMR genes. - Source: PubMed
Publication date: 2025/10/17
Ma WalfredChaisson Mark J P - Chronic pancreatitis (CP) is characterized by progressive fibrosis and irreversible pancreatic dysfunction, lacking disease-modifying therapies. We aimed to identify druggable targets through proteome-wide mendelian randomization (PW-MR). - Source: PubMed
Publication date: 2025/08/21
Li QinghuaChen WangqiLi XinyanZhu ZhenghuiYang YanqingXie YuxiaZhu Hong