AMPD2
- Known as:
- AMPD2
- Catalog number:
- 001538A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMPD2
Related genes to: AMPD2
- Gene:
- AMPD2 NIH gene
- Name:
- adenosine monophosphate deaminase 2
- Previous symbol:
- -
- Synonyms:
- SPG63
- Chromosome:
- 1p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-06
- Date modifiied:
- 2015-09-11
Related products to: AMPD2
Related articles to: AMPD2
- Excessive neuroinflammation exacerbates secondary brain injury after intracerebral hemorrhage (ICH). Adenosine monophosphate deaminase 2 (AMPD2) has been linked to immune regulation, but its role and mechanism in ICH-related neuroinflammation remain unclear. Emerging evidence underscores the importance of epigenetic modifications in post-ICH inflammation. This study aimed to determine whether AMPD2 contributes to neuroinflammation and whether folic acid (FA), a key methyl donor, attenuates inflammatory damage through epigenetic regulation of AMPD2. - Source: PubMed
Publication date: 2026/07/24
Xu YinbinHu JiahuiWu MengluYang JianhongDai ZifengXu TianqiGao XiangHuang YiZhou Shengjun - Hereditary spastic paraplegia (HSP) comprises a heterogeneous group of inherited neurodegenerative disorders characterized by progressive spasticity and weakness primarily of the lower extremities. Data describing pediatric HSP from the Levant region remain limited. - Source: PubMed
Publication date: 2026/07/14
Habanjar DimaKreidly SihamTrad SamahBoustany Rose-Mary - Spent brewer's yeast, a valuable but underexploited by-product in the beer industry, is rich in β-glucans, mannans, and RNA. This study proposed an integrated strategy for simultaneous production of polysaccharides and flavor nucleotides. Nuclease P1 (NP1) and AMP deaminase (AMPD) were displayed on yeast surface as reusable whole-cell biocatalysts, retaining >80% activity after 4 cycles, enhancing stability and reusability. Using crude yeast RNA, NP1 and AMPD2 whole-cell catalysts produced flavor nucleotides (5'-IMP + 5'-GMP) at 19.6 mg/g DCW. Alkali extraction of cell wall residue yielded high-purity β-glucans (>90%) and mannans (>35%). Economic evaluation showed that, per ton of spent yeast, products have an estimated value of ∼82.8 thousand CNY, based on an integrated assessment including polysaccharides, nucleotides, and residual proteins. This approach enables comprehensive high-value recycling and valorization of brewery waste. - Source: PubMed
Publication date: 2026/06/13
Du CongSu LiMingYuan RuoKeHe YingLi YiMinYuan WenJieBai FengWu - Adenosine monophosphate deaminase 2 (AMPD2) catalyzes the conversion of adenosine monophosphate (AMP) to inosine monophosphate and is believed to play a significant role in nucleotide metabolism, energy homeostasis, and immune oncology. Three primary AMPD isozymes, designated as M (muscle), L (liver), and E (erythrocyte) forms, have been identified. However, due to the high similarity of the catalytic site's amino acid sequence and structural topologies, most reported orthosteric inhibitors exhibit minimal selectivity toward AMPD isozymes. There is therefore a significant need for selective AMPD2 inhibitors as tools for validating the biological roles of AMPD2. In this study, we hypothesized that allosteric AMPD2 inhibitors would show selectivity towards other AMPD isoforms and used an X-ray fragment screening approach to identify these inhibitors. Consequently, we identified compound 5, which showed the capacity to bind to a previously uncharacterized allosteric site. The pharmacophore search based on structural information around 5 and the following X-ray screening also identified 6 and 8, which bind to the same site as 5. The merging of the initial fragment hit 5 with the secondary fragment hit 6 yielded 7, which was further merged with 8, resulting in the successful generation of 9. Moreover, the optimization of 9 led to more potent selective inhibitors 10g and 10h. Our results suggest that the fragment merging method using X-ray screening and pharmacophore searching provides effective opportunities to improve the affinity of the fragment hits. In addition, we believe that these selective compounds could be used as tool compounds for studying the biological roles of AMPD2. - Source: PubMed
Publication date: 2026/05/23
Yamanaka KenjiUhara ToruNomura AkihiroAkaki TatsuoAdachi TsuyoshiKitao YukiHantani Yoshiji - A two-year-old female patient was referred to our clinic due to speech and gait disturbances, strabismus, vacant staring, truncal hypotonia, and spasticity in the extremities. The patient had a history of a complicated delivery resulting in perinatal asphyxia. Electrocardiogram (ECG), echocardiogram (ECHO) and abdominal ultrasound findings reported no abnormalities. Previously performed spinal muscular atrophy (SMA) test, chromosomal microarray and karyotype analyses yielded normal results. On clinical examination, facial dysmorphic features included: prominently low-set ears, strabismus, downslanting palpebral fissures, micrognathia, and tapering fingers. - Source: PubMed
Publication date: 2026/05/12
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