AMOTL1
- Known as:
- AMOTL1
- Catalog number:
- 001535A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMOTL1
Related genes to: AMOTL1
- Gene:
- AMOTL1 NIH gene
- Name:
- angiomotin like 1
- Previous symbol:
- -
- Synonyms:
- JEAP
- Chromosome:
- 11q21
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-24
- Date modifiied:
- 2015-10-15
Related products to: AMOTL1
Related articles to: AMOTL1
- The Hippo pathway is a central regulator of tissue homeostasis, organ growth, and tumorigenesis. NF2 (Neurofibromin 2, also known as Merlin) functions as a pivotal upstream component that integrates biochemical and mechanical cues to restrain the activity of the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), thereby limiting cell proliferation. In addition, NF2 regulates members of the Motin family proteins (AMOT, AMOTL1, and AMOTL2) through ubiquitin-mediated turnover to modulate YAP/TAZ signaling output. Moreover, NF2 controls AMOT proteolytic processing to reorganize the actin cytoskeleton, thereby influencing cell motility. Through these mechanisms, NF2 establishes a multilayered regulatory system that coordinates cell proliferation and cell migration. This review summarizes recent advances in how NF2 regulates YAP/TAZ and AMOT functions, focusing on their roles in tumor formation, metastasis, and angiogenesis. - Source: PubMed
Publication date: 2026/08/31
Wang YuYu Fa-Xing - Predicting mortality in sepsis patients remains a challenge in clinical settings. This study aimed to identify genes associated with sepsis-related mortality and determine the predictive value of a model using these death-related genes. - Source: PubMed
Publication date: 2026/08/12
Bai YulongXu YubiaoTan ShihuiHuang YishengHuang XiaoxiangFu Zhaoyin - Severe steroid-resistant asthma (SSRA) is frequently associated with irreversible airway remodeling (AR), which contributes to persistent airflow limitation and poor therapeutic responsiveness. Celastrol (CEL) exhibits anti-inflammatory and tissue-protective properties; however, its role in steroid-resistant AR remains unclear. - Source: PubMed
Publication date: 2026/06/29
Sun JialiangLiu ZiyuZhang YingZhang YanqiuZhao PeiliangLi Yanan - Angiomotin-like 1 (AMOTL1), by regulating cell-cell junctions, cell polarity, and cell migration, plays a critical role in organogenesis and development. Recently, multiple studies have identified two hotspot mutations in AMOTL1, Arg157 (R157) and Pro160 (P160), in more than ten distinct families presenting with a spectrum of congenital defects, including facial dysmorphisms and cardiac abnormalities. However, the underlying pathogenic mechanism remains elusive. R157 and P160 are located in the highly conserved Tankyrase-binding motif (TBM) of AMOTL1. Here, we show that both the R157C and P160L mutants fail to interact with Tankyrase 1/2 and Ring finger protein 146, rendering them unable to undergo poly ADP-ribosylation, ubiquitination, and subsequent proteasomal degradation. As a result, these mutants are significantly stabilized and accumulate in the cytoplasm. Accumulated AMOTL1 mutants, in turn, disrupt cell junctions and focal adhesions, thereby inhibiting both the velocity and persistence of cell migration. Furthermore, during zebrafish embryonic development, expression of the R157C mutant leads to craniofacial malformations and defects in cardiac function and skeletal muscle. Our study confirms the role of AMOTL1 mutations in tissue development and uncovers the pathogenic mechanism at both molecular and cellular levels. - Source: PubMed
Luo JiaqianJin RuxinGeng FangWang YunyingZhu YuwenGao WenqiangGao WeiLi JianJiu YamingZhang RuilinYu Fa-XingWang Yu - Aerobic glycolysis drives cancer progression through phosphofructokinase (PFK)-mediated regulation. The contribution of platelet-type PFK (PFKP) to head and neck squamous cell carcinoma (HNSCC) pathogenesis remains undefined. - Source: PubMed
Publication date: 2026/02/13
Wang LingwaLi HaiyangYang YifanShi QianFeng LingWang RuFang Jugao