AMMECR1L
- Known as:
- AMMECR1L
- Catalog number:
- 001531A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMMECR1L
Related genes to: AMMECR1L
- Gene:
- AMMECR1L NIH gene
- Name:
- AMMECR1 like
- Previous symbol:
- -
- Synonyms:
- MGC4268
- Chromosome:
- 2q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-26
- Date modifiied:
- 2016-10-05
Related products to: AMMECR1L
Related articles to: AMMECR1L
- Prevention of human hypertension is an important challenge and has been achieved in experimental models. Brief treatment with renin-angiotensin system (RAS) inhibitors permanently reduces the genetic hypertension of the spontaneously hypertensive rat (SHR). The kidney is involved in this fascinating phenomenon, but relevant changes in gene expression are unknown. - Source: PubMed
Byars Sean GPrestes Priscilla RSuphapimol VarapornTakeuchi FumihikoDe Vries NathanMaier Michelle CMelo MarianaBalding DavidSamani NileshAllen Andrew MKato NorihiroWilkinson-Berka Jennifer LCharchar FadiHarrap Stephen B - Articular cartilage injuries are common orthopedic conditions that severely affect the quality of life of patients. Tissue engineering can facilitate cartilage repair and the key points involve scaffolding and seed cell selection. Pre-experiments found a range of microstructures of bioceramic scaffolds suitable for chondrocyte adhesion and proliferation, and maintaining chondrocyte phenotype. Three-dimensional cultures of bone marrow mesenchymal stem cell (BMSC) scaffolds were implanted into mice. According to the shape of the bioceramic scaffolds and the implantation time , RNA sequencing was performed on the removed scaffolds to explore the molecular mechanism. The bone plate culture can induce differentiation of chondrocytes, making culture different to that produced . Implantation of scaffolds increases the expression of bone-related genes. The ceramic rod-like material was found to be superior to the disc shape, and the bone repair effect was more marked with longer implantation times. Gene Ontology analysis revealed that 'cell chemotaxis', 'negative regulation of ossification' and 'bone development' pathways were involved in recovery. It was further confirmed that BMSCs were suitable as seed cells for cartilage tissue engineering, and that the β-tricalcium phosphate scaffold maybe ideal as cartilage tissue engineering scaffold material. The present research provided new insights into the molecular mechanism of cartilage repair by BMSCs and bioceramic scaffolds. Bioinformatics analysis revealed that AMMECR1L-like protein, tumor necrosis factor-induced protein 2, inhibitor of nuclear factor-B kinase subunit and protein kinase C type and 'negative regulation of ossification' and 'bone development' pathways may be involved in osteoblast maturation and bone regeneration. - Source: PubMed
Publication date: 2020/08/27
Huang XinChen ZhenhaoZhao GuangleiShi JingshengHuang GangyongChen FeiyanWei YibingXia JunChen JieWang Siqun - We report five individuals with loss-of-function of the X-linked AMMECR1: a girl with a balanced X-autosome translocation and inactivation of the normal X-chromosome; two boys with maternally inherited and de novo nonsense variants; and two half-brothers with maternally inherited microdeletion variants. They present with short stature, cardiac and skeletal abnormalities, and hearing loss. Variants of unknown significance in AMMECR1 in four male patients from two families with partially overlapping phenotypes were previously reported. AMMECR1 is coexpressed with genes implicated in cell cycle regulation, five of which were previously associated with growth and bone alterations. Our knockdown of the zebrafish orthologous gene resulted in phenotypes reminiscent of patients' features. The increased transcript and encoded protein levels of AMMECR1L, an AMMECR1 paralog, in the t(X;9) patient's cells indicate a possible partial compensatory mechanism. AMMECR1 and AMMECR1L proteins dimerize and localize to the nucleus as suggested by their nucleic acid-binding RAGNYA folds. Our results suggest that AMMECR1 is potentially involved in cell cycle control and linked to a new syndrome with growth, bone, heart, and kidney alterations with or without elliptocytosis. - Source: PubMed
Publication date: 2017/12/14
Moysés-Oliveira MarianaGiannuzzi GiulianaFish Richard JRosenfeld Jill APetit FlorenceSoares Maria de FatimaKulikowski Leslie DomeniciDi-Battista AdrianaZamariolli MalúXia FanLiehr ThomasKosyakova NadezdaCarvalheira GiannaParker MichaelSeaby Eleanor GEnnis SarahGilbert Rodney DHagelstrom R TannerCremona Maria LLi Wenhui LMalhotra AlkaChandrasekhar AnjanaPerry Denise LTaft Ryan JMcCarrier JulieBasel Donald GAndrieux JorisStumpp TaizaAntunes FernandaPereira Gustavo JoséNeerman-Arbez MargueriteMeloni Vera AyresDrummond-Borg MargaretMelaragno Maria IsabelReymond Alexandre