AMHR2
- Known as:
- AMHR2
- Catalog number:
- 001524A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMHR2
Related genes to: AMHR2
- Gene:
- AMHR2 NIH gene
- Name:
- anti-Mullerian hormone receptor type 2
- Previous symbol:
- -
- Synonyms:
- MISR2, MISRII
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-04-27
Related products to: AMHR2
Related articles to: AMHR2
- Sex-chromosome mosaicism can cause discordant gonadal, ductal, and external genital development. Persistent Müllerian derivatives are classically associated with defects in anti-Müllerian hormone (AMH) production or AMH receptor type 2 (AMHR2) signaling in otherwise normally virilized 46,XY individuals, termed persistent Müllerian duct syndrome (PMDS). In complex mosaicism, however, Müllerian persistence may reflect mixed gonadal dysgenesis (MGD). - Source: PubMed
Publication date: 2026/08/31
Zhang ShuaiZhou ChenyingLiu Dianyong - This study investigated the protective effects of caffeine (Caf) against aluminum chloride (AlCl₃)-induced ovarian toxicity in female Swiss Albino mice. Twenty-four adult female mice were equally divided into four groups (n = 6): control, Caf (40 mg/kg, oral), AlCl₃ (50 mg/kg, i.p.), and AlCl₃ + Caf, administered for seven consecutive days. AlCl₃ administration was associated with oxidative stress, as indicated by decreased ovarian glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels, along with increased malondialdehyde (MDA) levels. Caf pretreatment appeared to restore antioxidant enzyme activities and attenuate lipid peroxidation. Serum caspase-3 and caspase-9 levels were elevated following AlCl₃ administration, whereas Caf pretreatment was associated with reduced caspase levels. AlCl₃ exposure also led to increased serum interleukin-6 (IL-6), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (TNF-α) levels. Histopathological examination revealed granulosa cell degeneration, follicular atresia, disruption of the corona radiata, and reduced follicle numbers in the AlCl₃ group, whereas Caf appeared to alleviate these lesions, as confirmed by histopathological scoring and follicle counts. Immunohistochemical analyses demonstrated reduced anti-Müllerian hormone (AMH) and AMH receptor 2 (AMHR2) expression and increased caspase-3 immunoreactivity following AlCl₃ exposure. Caf pretreatment was associated with increased AMH and AMHR2 expression and reduced caspase-3 immunoreactivity. These findings suggest that Caf may exert protective effects against AlCl₃-induced ovarian injury, potentially through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. - Source: PubMed
Publication date: 2026/09/12
Başer LaleAyvazoğlu HalilUysal Ayfer YıldızDağ Serpil - Cryptorchidism is the most prevalent pediatric genital anomaly, yet its clinical significance often extends beyond simple anatomical maldescent. While surgical management is well-established, the necessity for holistic endocrine and genetic evaluation remains underexplored. We aimed to characterize the clinical, hormonal, and genetic landscapes of patients referred for pediatric endocrinological assessment following orchiopexy. - Source: PubMed
Publication date: 2026/08/26
Sütçü Zümrüt KocabeyKaplan Emel Hatun AytaçÖnal Hasan - Polycystic Ovary Syndrome (PCOS) is a common disorder characterized by hyperandrogenism and ovarian dysfunction. L-arginine and licorice extract, known for their antioxidant properties, are used to manage infertility. This study aimed to evaluate the effects of licorice extract and L-arginine on ovarian morphology, oocyte maturation, and pregnancy rates in PCOS-induced rats. Female rats were randomly assigned into six groups (n = 12): Group I (Control) received no treatment; Group II (Licorice) received 150 mg/kg licorice extract for 21 days; Group III (L-Arginine) received 22.9 mg/kg L-arginine for 21 days; Group IV (PCOS Model) received 1 mg/kg letrozole for 21 days to induce PCOS; Group V (Licorice + PCOS) received 150 mg/kg licorice extract post-PCOS induction; Group VI (L-Arginine + PCOS) received 22.9 mg/kg L-arginine post-PCOS induction. The study analyzed ovarian morphology, serum lipid profiles, antioxidant markers, nitric oxide levels, inflammatory cytokines, reproductive hormones, and Amhr2 gene expression, in conjunction with ovarian histopathology and immunohistochemistry for PCNA and Ki-67. L-arginine and licorice extract significantly improved lipid profiles, reduced oxidative stress (MDA, NO), and enhanced antioxidant activity (SOD, Catalase). They also showed beneficial effects on ovarian function, inflammation, and reproductive hormones, suggesting their therapeutic potential in managing PCOS. Fertility success improved from 33.3% in PCOS rats to 100% in both treatment groups, with increased litter sizes (9.25 ± 0.63 and 8.25 ± 0.75, respectively). - Source: PubMed
Publication date: 2026/08/24
El-Sayed YasmeenEl-Ghaweet Heba AElrefaeey Abdelaziz AAbou-El-Naga Amoura M - 17α-hydroxylase/17,20-lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia characterized by impaired cortisol and sex steroid synthesis with accumulation of mineralocorticoid precursors. Although hypertension, hypokalemia, and sexual infantilism represent the classical phenotype, atypical presentations are increasingly recognized. We report a 15-year-old phenotypically female adolescent presenting with primary amenorrhea, absent secondary sexual characteristics, and a karyotype. Despite biochemical evidence of complete 17α-hydroxylase/17,20-lyase deficiency, no hypertension was documented on repeated office and home blood pressure measurements, and serum potassium concentrations remained within the reference range during serial testing. Molecular analysis identified a homozygous pathogenic variant in (c.374G>A; p.Arg125Gln). Laparoscopy demonstrated no macroscopic Müllerian structures; however, histopathological examination of the bilateral gonadectomy specimens revealed bilateral microscopic Müllerian duct remnants within the perigonadal fibrous tissue. Serum anti-Müllerian hormone concentration was 12.58 ng/mL, within the expected range for a pubertal 46,XY individual. Targeted sequencing of and , together with additional genes relevant to gonadal development and 46,XY disorders of sex development, identified no pathogenic variants, likely pathogenic variants, or variants of uncertain significance. This case expands the clinicopathological spectrum of complete 17α-hydroxylase/17,20-lyase deficiency by demonstrating that microscopic Müllerian duct remnants may persist despite a serum AMH concentration within the expected range, with no molecular explanation identified by targeted genetic analysis. - Source: PubMed
Publication date: 2026/08/20
Bolaç Özyılmaz Leyla Gizemİnan ErtuğrulCanbek SezinAydın Behram BilgeDağdeviren Çakır AydilekTanık CananUçar Ahmet