AMHR2
- Known as:
- AMHR2
- Catalog number:
- 001524A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AMHR2
Related genes to: AMHR2
- Gene:
- AMHR2 NIH gene
- Name:
- anti-Mullerian hormone receptor type 2
- Previous symbol:
- -
- Synonyms:
- MISR2, MISRII
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-04-27
Related products to: AMHR2
Related articles to: AMHR2
- Cryptorchidism is the most prevalent pediatric genital anomaly, yet its clinical significance often extends beyond simple anatomical maldescent. While surgical management is well-established, the necessity for holistic endocrine and genetic evaluation remains underexplored. We aimed to characterize the clinical, hormonal, and genetic landscapes of patients referred for pediatric endocrinological assessment following orchiopexy. - Source: PubMed
Publication date: 2026/08/26
Sütçü Zümrüt KocabeyKaplan Emel Hatun AytaçÖnal Hasan - Polycystic Ovary Syndrome (PCOS) is a common disorder characterized by hyperandrogenism and ovarian dysfunction. L-arginine and licorice extract, known for their antioxidant properties, are used to manage infertility. This study aimed to evaluate the effects of licorice extract and L-arginine on ovarian morphology, oocyte maturation, and pregnancy rates in PCOS-induced rats. Female rats were randomly assigned into six groups (n = 12): Group I (Control) received no treatment; Group II (Licorice) received 150 mg/kg licorice extract for 21 days; Group III (L-Arginine) received 22.9 mg/kg L-arginine for 21 days; Group IV (PCOS Model) received 1 mg/kg letrozole for 21 days to induce PCOS; Group V (Licorice + PCOS) received 150 mg/kg licorice extract post-PCOS induction; Group VI (L-Arginine + PCOS) received 22.9 mg/kg L-arginine post-PCOS induction. The study analyzed ovarian morphology, serum lipid profiles, antioxidant markers, nitric oxide levels, inflammatory cytokines, reproductive hormones, and Amhr2 gene expression, in conjunction with ovarian histopathology and immunohistochemistry for PCNA and Ki-67. L-arginine and licorice extract significantly improved lipid profiles, reduced oxidative stress (MDA, NO), and enhanced antioxidant activity (SOD, Catalase). They also showed beneficial effects on ovarian function, inflammation, and reproductive hormones, suggesting their therapeutic potential in managing PCOS. Fertility success improved from 33.3% in PCOS rats to 100% in both treatment groups, with increased litter sizes (9.25 ± 0.63 and 8.25 ± 0.75, respectively). - Source: PubMed
Publication date: 2026/08/24
El-Sayed YasmeenEl-Ghaweet Heba AElrefaeey Abdelaziz AAbou-El-Naga Amoura M - 17α-hydroxylase/17,20-lyase deficiency (17OHD) is a rare form of congenital adrenal hyperplasia characterized by impaired cortisol and sex steroid synthesis with accumulation of mineralocorticoid precursors. Although hypertension, hypokalemia, and sexual infantilism represent the classical phenotype, atypical presentations are increasingly recognized. We report a 15-year-old phenotypically female adolescent presenting with primary amenorrhea, absent secondary sexual characteristics, and a karyotype. Despite biochemical evidence of complete 17α-hydroxylase/17,20-lyase deficiency, no hypertension was documented on repeated office and home blood pressure measurements, and serum potassium concentrations remained within the reference range during serial testing. Molecular analysis identified a homozygous pathogenic variant in (c.374G>A; p.Arg125Gln). Laparoscopy demonstrated no macroscopic Müllerian structures; however, histopathological examination of the bilateral gonadectomy specimens revealed bilateral microscopic Müllerian duct remnants within the perigonadal fibrous tissue. Serum anti-Müllerian hormone concentration was 12.58 ng/mL, within the expected range for a pubertal 46,XY individual. Targeted sequencing of and , together with additional genes relevant to gonadal development and 46,XY disorders of sex development, identified no pathogenic variants, likely pathogenic variants, or variants of uncertain significance. This case expands the clinicopathological spectrum of complete 17α-hydroxylase/17,20-lyase deficiency by demonstrating that microscopic Müllerian duct remnants may persist despite a serum AMH concentration within the expected range, with no molecular explanation identified by targeted genetic analysis. - Source: PubMed
Publication date: 2026/08/20
Bolaç Özyılmaz Leyla Gizemİnan ErtuğrulCanbek SezinAydın Behram BilgeDağdeviren Çakır AydilekTanık CananUçar Ahmet - Transverse testicular ectopia (TTE) is a rare anomaly often associated with persistent Müllerian duct syndrome and infertility. We report a 34-year-old man with primary infertility, a vacant right hemiscrotum, and a left scrotal mass. MRI showed both testes in the left hemiscrotum, with a heterogeneous right ectopic testicular tumor. Surgery confirmed TTE without gross Müllerian remnants; bilateral orchiectomy was performed because of malignancy and contralateral atrophy. Histopathology revealed seminoma. Genetic testing identified novel compound heterozygous variants. This case highlights the value of MRI, genetic evaluation, and early management to reduce infertility and malignant transformation risks in TTE patients worldwide. - Source: PubMed
Publication date: 2026/07/20
Ba Tien Dung MaiDang Quang TuanPham Van HaoHo Vinh Phuoc NguyenVo Minh DatHuynh Quang Huy - Ovarian aging is a critical factor influencing reproductive capacity and overall health. Granulosa cells (GCs) play essential roles in folliculogenesis; however, the mechanisms by which GC dysfunction contributes to ovarian aging remain incompletely understood. In this study, we identified insulin-like growth factor binding protein 4 (IGFBP4) as a negative regulator of ovarian function that is upregulated in GCs from aged cynomolgus monkey ovaries. Using an Igfbp4-HA tagged mouse model, we found that IGFBP4 expression in GCs increased during follicle development and was further elevated in aged mice. RNA-seq analysis of Igfbp4-deficient GCs revealed activation of the YAP pathway, which supports follicular development. Mechanistically, IGFBP4 reduced YAP nuclear localization in GCs, thereby restraining downstream YAP target gene expression and GC proliferation. In Amhr2-Cre; Igfbp4 mice, GC-specific deletion of Igfbp4 enhanced folliculogenesis, increased litter size and preserved reproductive performance with age. Elevated IGFBP4 levels were also detected in GCs from aging women and patients with premature ovarian insufficiency (POI). Furthermore, higher concentrations of IGFBP4 were observed in the follicular fluid of POI patients, supporting its potential as a biomarker of ovarian dysfunction. These findings establish IGFBP4 as a GC-derived suppressor of ovarian function and a potential target for preserving ovarian function during aging. - Source: PubMed
Publication date: 2026/07/16
Hu QianhuiGeng AjunLi ZiyuanGuo FanghaoWang JingqiangChen XinyiZhang MeilingZeng Yi ArialLi Wen