ALS2CL
- Known as:
- ALS2CL
- Catalog number:
- 001492A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ALS2CL
Related genes to: ALS2CL
- Gene:
- ALS2CL NIH gene
- Name:
- ALS2 C-terminal like
- Previous symbol:
- -
- Synonyms:
- FLJ36525, RN49018, DKFZp686I0110
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-05
- Date modifiied:
- 2014-11-19
Related products to: ALS2CL
Related articles to: ALS2CL
- Diabetes Mellitus is associated with increased risk of myocardial infarctions and strokes due to accelerated atherosclerotic plaque development and rupture. The mechanisms driving plaque rupture in the diabetic setting remain unclear. - Source: PubMed
Publication date: 2025/11/16
Bradford AngelleYoshida TadashiSukhanov SergiyWoods Foster FDelafontaine PatriceBazan Hernan AWoods T Cooper - A healthy uterine environment is essential for establishing and maintaining pregnancy and normal embryo development after insemination. In this context, the primary objectives of this study were to assess the genetic background of vaginal discharge score (VDS) traits during the voluntary waiting period in Holstein cows and to identify genomic regions and candidate genes influencing postpartum uterine health based on the integration of phenotypic, genomic, and transcriptomic datasets. Genetic parameters of 5 VDS traits defined according to lactation stage (VDS1, VDS2, VDS3, VDS4, and VDS5) were estimated based on VDS records from 64,241 Holstein cows that calved between 2019 and 2023 and genomic information from 2,489 cows. The GWAS were performed aiming to identify genomic regions associated with VDS traits. Differentially expressed genes and modular genes were obtained through RNA sequencing (RNA-seq) data of uterine secretion from 6 healthy and 6 diseased cows. The VDS traits had low-h estimates ranging from 0.006 ± 0.002 to 0.081 ± 0.011. Among the VDS traits, there were relatively strong genetic correlations between VDS1 (0-14 DIM) and metritis (0.678-0.763), as well as VDS3 (29-55 DIM) and endometritis (0.579-0.628). A total of 190 genes harboring 32 significant SNPs were identified as candidate genes regulating VDS in primiparous cows. The candidate genes identified were significantly enriched for pathways involved in cytokine-cytokine receptor interaction, mitogen-activated protein kinase signaling, and oxytocin signaling. Based on RNA-seq data of uterine secretions, 2,803 differentially expressed genes and 3,570 modular genes were identified. Furthermore, 7 genes were identified based on GWAS, differential gene expression, and weighted gene coexpression network analysis. The VSTM1, IL10RA, FXYD5, C2CD5, CETN4, ALS2CL, and PBX1 genes were considered to be the most promising candidate genes influencing postpartum uterine health in Holstein cows. This study provides novel insights on the genetic background of postpartum uterine health in Holstein cows. The results obtained can contribute to further refinements of selection indexes for improving uterine health and fertility in dairy cattle. - Source: PubMed
Publication date: 2025/03/04
Zhang JunxingHan LiyunSheng HuiZhang HailiangBrito Luiz FLi ShanshanJi GuoshangDan XingangCai BeiHu YameiWang YachunMa Yun - Electroconvulsive therapy (ECT) benefits patients with treatment-resistant depression (TRD), but the underlying biological processes are unclear. We conducted an epigenome-wide association study in 32 TRD patients undergoing ECT to depict ECT-associated methylation changes. Illness severity and ECT outcomes were assessed with the Montgomery-Åsberg Depression Rating Scale at baseline (T0) and 1 month after its end (T1). Methylation was profiled at T0 and T1 with the Illumina Infinium Methylation EPIC BeadChip array. - Source: PubMed
Publication date: 2024/07/17
Carvalho Silva RosanaMartini PaoloHohoff ChristaMattevi StefaniaBortolomasi MarcoAbate MariaMenesello ValentinaGennarelli MassimoBaune Bernhard TMinelli Alessandra - Prior studies have suggested a potential relationship between osteoporosis and sarcopenia, both of which can present symptoms of compromised mobility. Additionally, fractures among the elderly are often considered a common outcome of both conditions. There is a strong correlation between fractures in the elderly population, decreased muscle mass, weakened muscle strength, heightened risk of falls, and diminished bone density. This study aimed to pinpoint crucial diagnostic candidate genes for osteoporosis patients with concomitant sarcopenia. - Source: PubMed
Publication date: 2024/06/03
Zhou XiaoliZhao LinaZhang ZepeiChen YangChen GuangdongMiao JunLi Xiaohui - Molecular subtyping of gastric cancer (GC) aims to comprehend its genetic landscape. However, the efficacy of current subtyping methods is hampered by their mixed use of molecular features, a lack of strategy optimization, and the limited availability of public GC datasets. There is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and treatment. Based on TCGA subtypes, we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping (HCG), which employs gene mutations, copy number aberrations, and methylation patterns as predictors. By incorporating the closely related esophageal adenocarcinomas dataset, we expanded the TCGA GC dataset for the training and testing of HCG ( = 453). The optimization of HCG was achieved through three hierarchical strategies using Lasso-Logistic regression, evaluated by their overall the area under receiver operating characteristic curve (), , 1 score, the area under - curve () and their capability for clinical stratification using multivariate survival analysis. Subtype-specific DNA alteration biomarkers were discerned through difference tests based on HCG defined subtypes. Our HCG classifier demonstrated superior performance in terms of overall (0.95), (0.88), 1 score (0.87) and (0.86), significantly improving the clinical stratification of patients (overall -value = 0.032). Difference tests identified 25 subtype-specific DNA alterations, including a high mutation rate in the 1, 4, and 221 genes for the MSI subtype, and hypermethylation of 2, 0406, and 1 genes for the EBV subtype. HCG is an accurate and robust classifier for DNA-based GC molecular subtyping with highly predictive clinical stratification performance. The training and test datasets, along with the analysis programs of HCG, are accessible on the GitHub website (github.com/LabxSCUT). - Source: PubMed
Publication date: 2024/05/13
Yang BinyuLiu SiyingXie JieminTang XiGuan PanZhu YifanLiu XuemeiXiong YunhuiYang ZuliLi WeiyaoWang YonghuaChen WenLi QingjiaoXia Li C