AGAP3
- Known as:
- AGAP3
- Catalog number:
- 001279A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AGAP3
Related genes to: AGAP3
- Gene:
- AGAP3 NIH gene
- Name:
- ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
- Previous symbol:
- CENTG3
- Synonyms:
- -
- Chromosome:
- 7q36.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-29
- Date modifiied:
- 2019-03-26
Related products to: AGAP3
Related articles to: AGAP3
- Investigating the spatiotemporal patterns of gene expression in the brain is a critical step toward unraveling the molecular mechanisms underlying social behavior. While significant progress has been made in identifying neurogenomic states associated with diverse social contexts and their biological pathways, genomic studies often yield hundreds of candidate genes. This necessitates pinpointing key genes that drive behavior for more targeted research. In this study, we examine how the spatiotemporal expression of selected candidate genes varies between mating and social contexts. Building on insights from previous transcriptomic analyses, we identified promising gene candidates and examined their expression patterns in the female guppy brain (Poecilia reticulata). We evaluated these patterns within the brain's social decision-making network at 10 and 30 min post-exposure to either a mating or social stimulus. Genes such as gria1a, thap6, gria2, and agap3 exhibited the most pronounced differences in expression between mating and social contexts, suggesting their potential roles in regulating mating behavior. Employing a novel hierarchical coexpression network analysis, we captured the intricate gene expression changes underlying behavior. This approach allowed us to visualize distinct patterns of brain activity, revealing that the response to mating stimuli was localized to anterior nuclei, whereas the response to social stimuli was more evenly distributed across the social decision-making network. Additionally, we observed greater variability in gene expression between social and mating contexts at the 10-min time point. - Source: PubMed
Bittar AmauryBotia CatalinaMartínez SantiagoBernal DanielaAparicio NicolasGiraldo Luis FelipeAkle VerónicaBloch Natasha I - Despite the critical role of endocytosis-related genes in oncogenic processes, research exploring their potential for prognosticating hepatocellular carcinoma (HCC) remains limited. Establishing a connection between endocytosis and HCC is imperative. This study aimed to create a gene signature related to endocytosis to identify HCC subtypes and predict outcomes. - Source: PubMed
Publication date: 2025/06/27
Zhang LitingZhou DanGao XiaoqinLi JunfengXie Xiaodong - Primary pigmented papillary epithelial tumor of the sella (PPPET) is a recently identified tumor entity that commonly originates in the sella. To date, only three cases have been documented. These tumors are characterized by a papillary structure and significant melanin granule deposition. Notably, molecular characterization of PPPET remains unreported in the literature. A 42-year-old male presented with left-sided visual impairment for 2 weeks. Neuroimaging revealed a round sellar hyperdense mass. Histologically, the tumor exhibited minimal nuclear atypia and was characterized by a papillary architecture and obvious intracellular hyperpigmentation. Immunophenotypically, tumor cells showed diffuse positivity for S-100 and Melan-A, partial or focal positivity for synaptophysin and CD56, and negativity for TTF-1, GFAP, EMA, cytokeratins, and pituitary hormones. The Ki-67 proliferation index was low. The whole exome sequencing (WES) analysis revealed multiple potentially pathogenic gene mutations (AGAP3, DDX10, BBX, NFATC4, SLC6A6) in tumor tissues. Large genomic rearrangements (LGRs) involving PRKRA (exon6-8 del) and SKA3 (exon2-8 del) were detected. Genomic instability analysis indicated whole genome doubling (WGD) and aneuploidy in the tumor cells. Copy number variation (CNV) analysis demonstrated extensive copy number abnormalities at the chromosome arm level in tumor tissues. No classical mutations associated with known tumor types of the sella and choroid plexus were detected. PPPET has unique morphologic, immunohistochemical, and molecular genetic characteristics. Our findings suggest that PPPET may be an independent neurooncological entity. - Source: PubMed
Publication date: 2025/07/05
Wu ShuangYang XudanWang Xiaoqing - RET-fused Spitz neoplasms represent a rare and poorly characterized category of Spitz tumors. Here we describe the clinical, histologic, and molecular findings of 31 Spitz neoplasms with RET fusion diagnosed as Spitz nevus (n = 16), atypical Spitz tumors (n = 13), and Spitz melanoma (n = 2). The lesions mainly occurred in children and young adults of both sexes with a predilection for the extremities. Microscopically, they were mainly symmetrical compound melanocytic neoplasms with a dome-shaped/slightly raised silhouette predominantly composed of epithelioid, spindled, and/or smaller nevoid melanocytes arranged in confluent nests. Dyscohesive melanocytes within the nests in the upper part of the lesions, prominent Kamino bodies, giant multinucleated melanocytes, variable pigmentation, and increased vascularity with vascular ectasia were frequent features. RNA sequencing detected 9 different 5' (N-terminus) fusion partners, including KIF5B (n = 8), LMNA (n = 7), CCDC6 (n = 6), OPTN (n = 3), MYO5A (n = 2), and NCOA4, ERC1, MYH9, AGAP3 (n = 1). Of these, OPTN::RET and AGAP3::RET represent novel fusions, and 3 further 5' fusion partners, namely NCOA4, ERC1, and MYH9, have never been reported in Spitz tumors. Although as a whole group, the tumors showed a heterogeneous histopathologic presentation, correlation of the morphologic features and the 5' fusion partners demonstrated certain associations. Nevoid melanocytes were exclusively encountered in cases with KIF5B fusion partner. Neuroid-like appearances with intersecting fascicles of spindled cells typified both MYO5A-fused cases. Epithelioid melanocyte population dominated cases with LMNA and CCDC6 fusion partners. Transepidermal elimination/floating intraepidermal nests of pigmented spindled and epithelioid melanocytes were observed in the OPTN subgroup. The remaining cases with less frequent 5' fusion partners manifested in general more atypical histopathologic features, including nuclear pleomorphism, high mitotic count, atypical mitoses, and sheet-like growth pattern. Melanoma fluorescence in situ hybridization probe kit targeting RREB1, MYC, CDKN2A, and CCND1, was negative for copy number variation in 4 cases tested, including 2 cases with complete p16 nuclear loss on immunohistochemistry. Array comparative genomic hybridization was performed in 3 lesions and detected numerous segmental chromosomal imbalances in 2 of them that were diagnosed as Spitz melanoma. DNA and RNA sequencing detected several further genomic alterations, including POU2F3 overexpression in 3 highly pigmented lesions. Further studies are needed to confirm possible correlations between the microscopic features and a particular fusion partner (or additional genetic events) in RET-fused Spitz neoplasms. - Source: PubMed
Publication date: 2025/02/20
Donati MicheleGoutas DimitriosPissaloux DanielOlivares ShantelKervarrec ThibaultNosek DanielGoto KeisukeLemahieu JulieLoontiens SiebeVan der Meulen JoniMansour BoulosPerrone GiuseppeMacagno NicolasGerami PedramKazakov Dmitry VDe la Fouchardiere Arnaud - Gene fusions offer new therapeutic options for patients with metastatic colon cancer (CC). gene fusions are infrequent somatic mutations found in CC with prognostic and promising targeted therapies. CC diagnosed before the age of 50 was regarded as early-onset CC (EOCC). The incidence of EOCC is increasing, yet there is a clear unmet need to improve the management of EOCC. Herein, we selectively reported a case of metastatic EOCC with rare gene fusions. The right-sided tumors were radically resected. Next-generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded tissues to eliminate gene variations. Histologically, the colonic hepatic flexure showed focal mucinous adenocarcinoma changes along with high-grade intraepithelial neoplasia. The results of histopathological examination belonged to pT1bN1bM0 ⅢA stage. Targeted DNA sequencing revealed (A10;B9) fusion and (B8;A11) fusion were simultaneously detected in this case. Microsatellite instability-high (MSI-H) and mutations were not detected. During a limited 1.5-year follow-up period, neither a confirmed local recurrence nor a distant organ metastasis occurred in this case. We propose that fusion variations can occur in metastatic EOCC. - Source: PubMed
Publication date: 2024/11/28
Zhao TingtingYang JuntingWang MeirongLiu Jie