AFF2
- Known as:
- AFF2
- Catalog number:
- 001266A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AFF2
Related genes to: AFF2
- Gene:
- AFF2 NIH gene
- Name:
- AF4/FMR2 family member 2
- Previous symbol:
- FMR2
- Synonyms:
- FRAXE
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-27
- Date modifiied:
- 2019-03-26
Related products to: AFF2
Related articles to: AFF2
- Sinonasal papilloma (SP) has a recognized potential for malignant transformation, most commonly into squamous cell carcinoma (SCC). Well-established criteria for malignancy are lacking in SP and often depends on subjective features, such as stromal invasion without desmoplasia or assessment of dysplastic epithelium-to-stroma ratio, which can lead to under- or over-diagnosis, particularly in small biopsies. Additionally, emerging entities that mimic dysplastic papillomas necessitate re-evaluation of previously diagnosed “atypical/dysplastic SP” cases. - Source: PubMed
Publication date: 2026/04/20
Amin Sara ESono ReiriAl-Jumaili Zubaidah IAk SibelHang Jen-FanElsayad MahmoudSaluja Karan - An increased understanding of molecular alterations over the last decade has also impacted the landscape of sinonasal squamous cell carcinoma (SNSCC). In addition to traditional SCC risk factors (e.g. smoking) and high-risk HPV (HR- HPV), other drivers are emerging, such as DEK::AFF2 fusion in non-keratinizing and papillary SNSCC. Treatment of squamous cell carcinoma has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. We describe a case report of nasal nonkeratinizing squamous cell carcinoma- HPV-high risk (HPV-HR) positive and harboring an MKRN1::BRAF fusion. We further discuss the significance of these findings, integrated in the context of current literature. - Source: PubMed
Publication date: 2026/03/13
Bell DianaWang Eric WChoby GarretSnyderman CarlArivarasan KarunamurthySeethala Raja R - piRNAs (PIWI-interacting RNAs) can significantly modify the expression of protein-coding genes by suppressing the translation process. The aim of this work was to computationally evaluate the potential interactions between piRNAs and the mRNA of the gene, as well as other genes involved in key metabolic pathways related to health and lifespan regulation. - Source: PubMed
Publication date: 2026/02/18
Pyrkova AnnaAkhmetova KyrmyzyZhanuzakov MuratTauassarova MakpalRakhmetulina AizhanNiyazova RaigulOrazova SaltanatZielenkiewicz PiotrIvashchenko Anatoliy - The nasal cavities and sinuses are the site of many tumoral entities, which are increasingly well described, especially since the advent of molecular biology. The present systematic review collates the current state of knowledge on six new entities described in the 2017 and 2022 versions of the WHO classification of sinonasal tumors: DEK::AFF2 rearranged squamous cell carcinoma, HPV-associated multiphenotypic sinonasal carcinoma, NUT carcinoma, SMARCB1-deficient and SMARCA4-deficient carcinoma, biphenotypic sinonasal sarcoma, and adamantinoma-like Ewing sarcoma. A systematic literature search was performed on PubMed. The inclusion criteria focused on English-language articles precisely describing the histologic, immunohistochemical, molecular, clinical and prognostic characteristics of these entities. It is essential to be able to identify these entities, as they have distinct profiles in terms of progression and prognosis compared to other sinonasal tumors. The present study exhaustively describes their clinical and pathologic characteristics. - Source: PubMed
Publication date: 2026/02/16
Lépine CCastain CBaglin A-CCostes-Martineau V - fusion carcinoma is an emerging sinonasal tract non-keratinizing squamous cell carcinoma (SCC) variant, characterized by deceptively bland morphology, frequent local recurrence, and metastasis in a subset of cases. Owing to its histologic mimicry, misdiagnosis remains common. We report a case of neoplasm exhibiting malignant histological evidence strictly confined to the pulmonary “metastatic” lesion despite persistent benign radiologic and pathologic features in six nasal cavity tumor resections over two decades in a 35-year-old male. The patient was initially diagnosed with inverted papilloma (IP) of the nasal cavity. Histopathologic reassessment of the lung lesions, however, demonstrated divergent morphology—hybrid SCC and IP-like components. Molecular studies (FISH, RNA-seq) confirmed identical fusion in both nasal cavity and pulmonary tumors, supporting clonal spread. This case underscores that sinonasal carcinomas can retain benign histology in primary and recurrent lesions while exhibiting overt malignancy in “metastatic” sites. For sinonasal papillomatous tumors, even if the primary tumor lacks overt malignant histological features, atypical clinical behaviors, such as persistent recurrence or development of distant similar lesions, should raise suspicion for SCC. DEK FISH or RNA sequencing should be considered for definitive diagnosis when clinically indicated. - Source: PubMed
Publication date: 2026/01/26
Chen YongqiLu MengjieSun ZhenkuiLiu KunMeng JiaoYan HuaruChang Bin