ADSL
- Known as:
- ADSL
- Catalog number:
- 001250A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADSL
Related genes to: ADSL
- Gene:
- ADSL NIH gene
- Name:
- adenylosuccinate lyase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 22q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2014-11-18
Related products to: ADSL
Adenylosuccinase,Adenylosuccinate lyase,Adl,Adsl,ASase,ASL,Mouse,Mus musculusAdenylosuccinase,Adenylosuccinate lyase,ADSL,AMPS,ASase,ASL,Homo sapiens,HumanAdenylosuccinase,Adenylosuccinate lyase,ADSL,ASase,ASL,Bos taurus,BovineAdenylosuccinase,Adenylosuccinate lyase,ADSL,ASase,ASL,Chicken,Gallus gallusADRBK2 Gene adrenergic, beta, receptor kinase 2ADSL (Human) Recombinant Protein (P01)ADSL 293T Cell Transient Overexpression Lysate(Denatured)ADSL 3&_39;UTR Lenti-reporter-Luc VectorADSL antibodyADSL antibodyADSL antibodyADSL antibodyADSL AntibodyADSL AntibodyADSL antibody Related articles to: ADSL
- Cochlear implantation is a common treatment for adults with single-sided deafness (SSD), but patient-reported benefits vary. The relationships among tinnitus burden, perceived hearing ability, psychological distress, disease-specific health-related quality of life, and whether early postoperative outcomes predict later results are not well understood. - Source: PubMed
Publication date: 2026/04/15
Schrader Jasper Karl FriedrichGröschel MoritzSzczepek Agnieszka JOlze Heidi - Septic tibial nonunion regarding proximal metaphysis is a rare complication with devastating results. - Source: PubMed
Publication date: 2026/04/22
Sidiropoulos KonstantinosPanagopoulos AndreasSaridis AlkisAssimakopoulos Stelios FSaridis Alexandros ALakoumentas JohnKouzelis AntonisKoukos ChristosGivissis Panagiotis - Interpreting variants in recessive diseases is difficult because clinical severity depends on the combined function of both alleles. Deep mutational scanning (DMS) experiments can provide functional measurements at scale, but their scores often relate nonlinearly to true biochemical activity. Here, we describe a method for inferring enzymatic activities for thousands of variants by running two fitness assays at different expression levels and modeling the nonlinear activity-fitness relationship. These inferred activities allow the computation of a bi-allelic pathogenicity score that captures the joint effect of two alleles. We applied this approach to adenylosuccinate lyase (ADSL), quantifying the effects of >8,000 coding variants in a yeast-based DMS assay. The inferred activities separated pathogenic from benign alleles, and the bi-allelic scores correlated strongly with biochemical measurements and clinical outcomes, outperforming existing predictors. This framework provides a broadly applicable strategy for the mechanistic interpretation of variants in recessive enzymes. - Source: PubMed
Publication date: 2026/04/21
Çubuk HasanPlech MarcinAslanzadeh VahidZikanova MarieSkopova VaclavaKmoch StanislavShen YuxinMarsh Joseph AKudla Grzegorz - Inosine monophosphate (IMP) is a major flavor compound in meat. Given the observed positive correlation between adenylate kinase 1 (AK1) expression and IMP content in Beijing-You chickens (BJYs), we investigated the role of AK1 in regulating myoblast proliferation and differentiation. Cell counting kit-8 (CCK-8) assays, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, flow cytometry, and Western blotting showed that AK1 promoted myogenic differentiation and suppressed the proliferative activity of myoblasts. During the proliferation of myoblasts, glutamine phosphoribosylpyrophosphate amidotransferase (GPAT) was suppressed by AK1 and adenylosuccinate synthase (ADSS) was enhanced, which led to reduced IMP accumulation and inhibited uric acid (UA) and adenosine triphosphate (ATP) production. During myoblast differentiation, the protein expression of de novo IMP synthesis genes, including GPAT, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (PurH), and adenylosuccinate lyase (ADSL), was upregulated, while ADSS was downregulated by AK1, resulting in enhanced IMP deposition and stimulated production of UA and ATP. In summary, this study elucidates the regulatory role of AK1 in coordinating the proliferation and differentiation of myoblasts, as well as its stage-specific modulation of IMP anabolism. These findings provide theoretical insights into the molecular mechanisms governing IMP deposition and offer potential guidance for improving meat flavor quality in chicken through molecular breeding strategies. - Source: PubMed
Publication date: 2026/03/23
Hou JingyanZhang YaoZhu LiyangQi XiaolongWang XiangguoLin ZiliXiao LongfeiLong ChengDou JinhuanXu YaxiSheng Xihui - Traditional evaluation of DNA methylation in fish using invasive tissue biopsy limits its application for in vivo monitoring and genetic selection for resistant individuals. As a non-invasive approach, plasma circulating cell-free DNA (cfDNA) testing has become a prospective strategy for studying individual epigenetic states and immune responses recently. In this study, the genome-wide methylation profiles in cfDNA by whole-genome bisulfite sequencing (WGBS) were evaluated for the GIFT strain of Nile tilapia (Oreochromis niloticus) following Streptococcus agalactiae infection. The cfDNA concentration in the susceptible group (2.72 ± 1.46 ng/μL) was significantly higher than that in the control (1.12 ± 0.38 ng/μL) and resistant group (1.23 ± 0.72 ng/μL). A total of 3076 differentially methylated regions (DMRs) were identified between resistant and susceptible groups, and the DMR-associated genes were significantly enriched in pathways related to transcriptional regulation, immune response, and energy metabolism. By integrating published spleen methylation data and conducting RNA-seq in spleen, we further explored the potential tissue origin of cfDNA methylation markers. Approximately 7.6% of cfDNA DMRs (234) overlapped with the spleen DMRs, and 111 overlapping DMRs with consistent methylation direction showed a strong correlation between the cfDNA and spleen datasets (R = 0.928, p < 1.31e - 48). Promoter methylation levels in cfDNA were negatively correlated with gene expression in spleen transcriptome data. 100 differentially expressed genes (DEGs) that were detected in spleen data were also observed in the cfDNA gene dataset with differentially methylated promoters (DMPs). BS-PCR and qRT-PCR analyses confirmed significant differences in methylation and expression of candidate genes b4galt1l, pigr and adsl across four immune-related tissues (spleen, head kidney, liver, and hindgut) between the control and infected groups. In summary, this study provides a valuable epigenetic dataset for developing epigenetic biomarkers in GIFT tilapia breeding for resistance to S. agalactiae and indicates that spleen could be one of the potential tissue sources of cfDNA methylation marks. - Source: PubMed
Publication date: 2026/03/25
Jiao Ji PingQiao Tao FeiDong Meng FanZhu Zong XianPan Jin MinXia Jun Hong