ADRA2A
- Known as:
- ADRA2A
- Catalog number:
- 001241A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADRA2A
Related genes to: ADRA2A
- Gene:
- ADRA2A NIH gene
- Name:
- adrenoceptor alpha 2A
- Previous symbol:
- ADRA2, ADRA2R
- Synonyms:
- ADRAR
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2019-03-22
Related products to: ADRA2A
Related articles to: ADRA2A
- This study evaluated whether dexmedetomidine (Dex) attenuates hypoxia/reoxygenation (H/R)-induced injury in H9c2 cells and examined concurrent changes in adrenergic receptor candidates, Notch receptor 1 (Notch1), and hairy and enhancer of split-1 (Hes1) expression to develop a hypothesis-generating model of Dex-associated protection. H9c2 cells underwent 12 h of hypoxia followed by 4 h of reoxygenation. Cell viability, myocardial injury markers, oxidative stress, inflammatory cytokines, apoptosis, candidate-gene expression, and NOTCH1 and HES1 protein abundance were assessed. Notch1 overexpression was used to test the functional relevance of increased Notch1 abundance. Network pharmacology, qRT-PCR profiling of six intersection targets, and molecular docking were integrated to prioritize receptor candidates and generate testable hypotheses. Dex improved cell viability and reduced myocardial injury following H/R. Dex increased alpha-2A adrenergic receptor (Adra2a) and alpha-2B adrenergic receptor (Adra2b) mRNA expression and reduced Notch1/Hes1 expression. Notch1 overexpression weakened several Dex-associated protective effects. Network pharmacology and six-target qRT-PCR validation prioritized ADRA2A and ADRA2B as Dex-responsive receptor candidates. Molecular docking further predicted favorable Dex binding to ADRA2B and ADRA2A, with AutoDock Vina scores of - 8.8 and - 7.4 kcal/mol, respectively. Dex attenuated H/R-induced injury in H9c2 cells. This protective phenotype was accompanied by increased Adra2a and Adra2b mRNA expression and reduced Notch1/Hes1 expression, whereas Notch1 overexpression weakened several Dex-associated protective effects. These correlative findings propose a hypothesis-generating model, providing a focused rationale for future studies to investigate the specific receptor-level mechanisms underlying Dex-mediated cardioprotection. - Source: PubMed
Publication date: 2026/09/25
Xue DinghaoChang XinluZhang MingruWang Guyan - Sleep bruxism (SB) is a centrally regulated, arousal-related motor behaviour, but no pharmacotherapy has demonstrated reliable clinical efficacy. This study aimed to identify pathway-level signals most consistently supported by current polysomnography (PSG)-based pharmacotherapy evidence for SB. - Source: PubMed
Publication date: 2026/09/22
Li DeshuiSun ShanliangChen HuiCi XiaojiaLuo JiayiWei Fulan - COVID-19 remains a relevant area of biomedical investigation because its pathogenesis involves complex virus-host interactions. This study aimed to explore, through purely in silico and hypothesis-generating insights, the predicted molecular associations between benzyl isothiocyanate (BITC) from and COVID-19-associated host-response pathways. BITC-associated targets were collected from compound-target databases, while COVID-19-associated targets were obtained from disease-gene databases and transcriptomic datasets. Overlapping targets were analyzed using protein-protein interaction network construction, hub-gene prioritization, Gene Ontology and KEGG enrichment analyses, and molecular docking. A total of 271 unique BITC-associated targets and 1890 COVID-19-associated targets were identified, with 36 candidate targets overlapping. PPI analysis generated a connected network of 24 nodes and 39 edges. Hub-gene analysis prioritized ACE, JUN, MAOA, CDK1, MAOB, HCK, CCNA2, ACHE, GADD45A, and ADRA2A. Enrichment analysis indicated associations with inflammatory response, vascular regulation, calcium homeostasis, monoamine oxidase activity, NF-κB signaling, serotonergic synapse, and tryptophan metabolism. Validated active-site docking of six targets yielded comparative Vina scores ranging from -5.380 to -6.437 kcal/mol. These preliminary findings provide theoretical target-pathway associations supporting further investigation of BITC as a potential immunomodulatory candidate within COVID-19-related host-response pathways. - Source: PubMed
Publication date: 2026/08/21
Sumague Terrence SuministradoAziz Ibrahim MAljowaie Reem MAlsaleh Asma NAlkubaisi Noorah AAlmajhdi Fahad N - The role of Phosphoglycerate Dehydrogenase (PHGDH), the first key enzyme in the serine biosynthesis pathway, is important in controlling cancer survival; however, its role in rheumatoid arthritis (RA) remains unknown. Here, we investigated the functional involvement of PHGDH in RA pathogenesis, as well as its underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/08/20
Sun KaiLiu TingXu XuanxianDong HuanHu HuijuanPeng ChenxiGe XiaofanLiang LiuqinXiao YoujunXu HanshiQiu Qian - stems and leaves are abundant agricultural residues generated during root harvest, rich in flavonoids yet remain largely underutilized as a valuable phytochemical source. This study optimized a green steaming-sodium bicarbonate aqueous extraction process via orthogonal design. Optimal conditions (steaming 1 h, 1.0% food-grade NaHCO, boiling extraction 2 h, 1:20 g/mL) achieved a solid yield of 13.50 ± 0.41%, significantly higher than conventional water extraction (7.98 ± 0.41%, < 0.05), demonstrating enhanced recovery of bioactive compounds. The extract exhibited 91.95 ± 0.08% xanthine oxidase inhibition (IC = 5.0 mg/mL) with reversible mixed-type inhibition ( = 4.99 mg/mL). UHPLC-MS/MS identified 3392 metabolites, predominantly flavonoids, alkaloids, and organic acids with potential XO inhibitory activity. Network pharmacology and molecular docking revealed multi-target interactions involving ADRA2A, ADA, GAA, PNP, and PTGS2 enriched in purine metabolism and AGE-RAGE signaling pathways, with quercetin 3-Gentiobioside exhibiting the strongest binding affinity and favorable ligand-target interactions (ΔG = -12.91 kcal/mol). This eco-friendly strategy employs only pure water and food-grade additives, efficiently concentrating xanthine oxidase inhibitors and offering a clean-label, sustainable approach for high-value utilization of agricultural residues. These findings provide a pharmacological basis for developing functional foods targeting hyperuricemia and associated metabolic disorders. - Source: PubMed
Publication date: 2026/07/27
Cao ZuomingWang YanYang ZuotingGao XiaoyuSheng JunTian YangPeng Lei