ADRA2A
- Known as:
- ADRA2A
- Catalog number:
- 001241A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADRA2A
Related genes to: ADRA2A
- Gene:
- ADRA2A NIH gene
- Name:
- adrenoceptor alpha 2A
- Previous symbol:
- ADRA2, ADRA2R
- Synonyms:
- ADRAR
- Chromosome:
- 10q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2019-03-22
Related products to: ADRA2A
Related articles to: ADRA2A
- COVID-19 remains a relevant area of biomedical investigation because its pathogenesis involves complex virus-host interactions. This study aimed to explore, through purely in silico and hypothesis-generating insights, the predicted molecular associations between benzyl isothiocyanate (BITC) from and COVID-19-associated host-response pathways. BITC-associated targets were collected from compound-target databases, while COVID-19-associated targets were obtained from disease-gene databases and transcriptomic datasets. Overlapping targets were analyzed using protein-protein interaction network construction, hub-gene prioritization, Gene Ontology and KEGG enrichment analyses, and molecular docking. A total of 271 unique BITC-associated targets and 1890 COVID-19-associated targets were identified, with 36 candidate targets overlapping. PPI analysis generated a connected network of 24 nodes and 39 edges. Hub-gene analysis prioritized ACE, JUN, MAOA, CDK1, MAOB, HCK, CCNA2, ACHE, GADD45A, and ADRA2A. Enrichment analysis indicated associations with inflammatory response, vascular regulation, calcium homeostasis, monoamine oxidase activity, NF-κB signaling, serotonergic synapse, and tryptophan metabolism. Validated active-site docking of six targets yielded comparative Vina scores ranging from -5.380 to -6.437 kcal/mol. These preliminary findings provide theoretical target-pathway associations supporting further investigation of BITC as a potential immunomodulatory candidate within COVID-19-related host-response pathways. - Source: PubMed
Publication date: 2026/08/21
Sumague Terrence SuministradoAziz Ibrahim MAljowaie Reem MAlsaleh Asma NAlkubaisi Noorah AAlmajhdi Fahad N - The role of Phosphoglycerate Dehydrogenase (PHGDH), the first key enzyme in the serine biosynthesis pathway, is important in controlling cancer survival; however, its role in rheumatoid arthritis (RA) remains unknown. Here, we investigated the functional involvement of PHGDH in RA pathogenesis, as well as its underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/08/20
Sun KaiLiu TingXu XuanxianDong HuanHu HuijuanPeng ChenxiGe XiaofanLiang LiuqinXiao YoujunXu HanshiQiu Qian - stems and leaves are abundant agricultural residues generated during root harvest, rich in flavonoids yet remain largely underutilized as a valuable phytochemical source. This study optimized a green steaming-sodium bicarbonate aqueous extraction process via orthogonal design. Optimal conditions (steaming 1 h, 1.0% food-grade NaHCO, boiling extraction 2 h, 1:20 g/mL) achieved a solid yield of 13.50 ± 0.41%, significantly higher than conventional water extraction (7.98 ± 0.41%, < 0.05), demonstrating enhanced recovery of bioactive compounds. The extract exhibited 91.95 ± 0.08% xanthine oxidase inhibition (IC = 5.0 mg/mL) with reversible mixed-type inhibition ( = 4.99 mg/mL). UHPLC-MS/MS identified 3392 metabolites, predominantly flavonoids, alkaloids, and organic acids with potential XO inhibitory activity. Network pharmacology and molecular docking revealed multi-target interactions involving ADRA2A, ADA, GAA, PNP, and PTGS2 enriched in purine metabolism and AGE-RAGE signaling pathways, with quercetin 3-Gentiobioside exhibiting the strongest binding affinity and favorable ligand-target interactions (ΔG = -12.91 kcal/mol). This eco-friendly strategy employs only pure water and food-grade additives, efficiently concentrating xanthine oxidase inhibitors and offering a clean-label, sustainable approach for high-value utilization of agricultural residues. These findings provide a pharmacological basis for developing functional foods targeting hyperuricemia and associated metabolic disorders. - Source: PubMed
Publication date: 2026/07/27
Cao ZuomingWang YanYang ZuotingGao XiaoyuSheng JunTian YangPeng Lei - Chronic stress is a major precipitating factor for anxiety disorders, yet current pharmacotherapies are limited by delayed onset of action and adverse effects, highlighting the need for safer and more effective alternatives. Tongren Niuhuang Qingxin Wan (NHQXW), a traditional Chinese medicine formulation, has been used clinically to alleviate symptoms including palpitations, insomnia, and anxiety-related discomfort; however, its potential to mitigate stress-induced anxiety-like behaviors in preclinical models, along with the underlying molecular mechanisms, remains largely unexplored. In this study, using the chronic unpredictable mild stress (CUMS) mouse model, we assessed anxiety-like behaviors via the open field, elevated plus maze, and light-dark box tests. Neurotransmitter levels were measured by LC-MS/MS, and associated molecular alterations were investigated using non-targeted proteomics, followed by RT-qPCR and western blotting for validation. NHQXW attenuated the development of CUMS-induced anxiety-like behavioral alterations and reduced the stress-associated elevation of norepinephrine in the PFC. Proteomic analysis identified 107 differentially expressed proteins in the PFC of high-dose NHQXW-treated mice compared to CUMS controls, primarily enriched in adrenergic signaling, synaptic plasticity, and stress-related pathways. Subsequent validation showed that NHQXW upregulated the expression of α2A-adrenergic receptor (ADRA2A) and its coupled G protein subunit GNAI2, normalized glucocorticoid receptor expression, and protected synapse-related proteins. These findings suggest that the protective effects of NHQXW may be associated with modulation of prefrontal noradrenergic signaling and synaptic plasticity. This study provides a molecular rationale for the therapeutic potential of NHQXW as a novel, multi-targeted intervention for stress-related anxiety disorders, paving the way for future translational research and clinical applications. - Source: PubMed
Publication date: 2026/08/03
Wang JianxiongGao DanCheng ZizhaoZhang LiHao JinpingChen YingjieLi HuilingLi JinshengZhang Lan - Cerebellar climbing fiber-Purkinje cell (CF-PC) long-term depression (LTD) plays a critical role in motor learning and is modulated by locus coeruleus (LC) noradrenergic afferents via distinct adrenergic receptor (AR) subtypes. Nevertheless, the mechanisms underlying LC noradrenergic neuron-mediated regulation of CF-PC LTD remain poorly understood. Here, we investigated the effects of chemogenetic activation of LC noradrenergic afferents on CF-PC LTD in cerebellar slices from dopamine β-hydroxylase (DBH)-Cre mice using electrophysiology, glutamate sensor imaging, immunofluorescence and pharmacological approaches. Tetanic stimulation (5 Hz) of CFs induced CF-PC LTD under control conditions, and this LTD was enhanced by chemogenetic activation of LC noradrenergic afferents. Blockade of group I metabotropic glutamate receptors (mGluR1) abolished LTD under control conditions, whereas chemogenetic activation of LC noradrenergic afferents triggered a novel form of CF-PC LTD accompanied by an increased N2/N1 ratio. With mGluR1 blocked, chemogenetic activation of LC noradrenergic afferents failed to trigger the novel CF-PC LTD following blockade of α-AR or αA-AR, but not αB-AR or αC-AR. Importantly, chemogenetic activation of LC noradrenergic afferents triggered LTD of glutamate fluorescence at CF terminals, which was abolished by blockade of αAR or αA-AR, but not αB-AR or αC-AR. Notably, inhibition of either cyclin-dependent kinase 5 (CDK5) or presynaptic, but not postsynaptic, protein kinase A (PKA) completely abolished the CF-PC LTD triggered by chemogenetic activation of LC noradrenergic afferents in mouse cerebellar slices. Immunofluorescence results showed robust αA-AR expression throughout the cerebellar molecular layer, with intense signals along PC dendrites and clear colocalization with vesicular glutamate transporter 2 (vGluT2) at cerebellar CF terminals. These results indicate that activation of LC noradrenergic afferents potentiates CF-PC LTD by triggering Glu-LTD at CF terminals through the αA-AR/CDK5/PKA signaling cascade in the mouse cerebellar cortex. - Source: PubMed
Publication date: 2026/07/17
Zhang Xu-DongXu Ying-HanWu Wang-TongZheng Lang-YueXu Xin-YiChu Chun-PingQiu De-Lai