ADHFE1
- Known as:
- ADHFE1
- Catalog number:
- 001218A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADHFE1
Related genes to: ADHFE1
- Gene:
- ADHFE1 NIH gene
- Name:
- alcohol dehydrogenase iron containing 1
- Previous symbol:
- -
- Synonyms:
- ADHFe1, FLJ32430
- Chromosome:
- 8q13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-09
- Date modifiied:
- 2019-01-21
Related products to: ADHFE1
Related articles to: ADHFE1
- Diabetic kidney disease (DKD) is a multifactorial complication of diabetes involving mitochondrial dysfunction and immune cell infiltration. However, the causal relationships remain unclear. - Source: PubMed
Publication date: 2025/12/25
Zhang TianyueWu JunxiaZhang JiazhiHu YepengZhao YimingMao GuangyunJiao JingjingWang JunChen RiqiuZheng Chao - Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, and EGFR-mutant tumors show limited response to current immunotherapy. The immunosuppressive tumor microenvironment, particularly metabolic constraints on effector T cells, is increasingly recognized as a major barrier to effective anti-tumor responses. HHLA2, a B7 family member frequently elevated in EGFR-mutant NSCLC, has an incompletely defined role in immune escape. In this study, we demonstrate that tumor-derived HHLA2 engages the inhibitory receptor KIR3DL3 on CD8 T cells, driving T cell exhaustion through metabolic reprogramming of amino acid utilization. HHLA2-KIR3DL3 signaling suppresses glutamine utilization through ERK/MAPK-dependent repression of SLC1A5, SLC38A2, and ADHFE1, key glutamine transporters and metabolic enzymes, thereby inducing metabolic insufficiency and dysfunctional cytokine production in CD8 T cells, including reduced IFN-γ, TNF-α, and increased IL-10. Disruption of this axis-via HHLA2 deletion or antibody blockade-restored T cell metabolism and effector function, leading to attenuated tumor progression in humanized mouse models. Notably, HHLA2/KIR3DL3 inhibition synergized with EGFR tyrosine kinase inhibitors to enhance anti-tumor immunity and suppress tumor progression. Together, these findings identify HHLA2-KIR3DL3 as a key immunosuppressive pathway in EGFR-mutant NSCLC and may provide a rationale for therapeutic targeting to improve clinical outcomes. - Source: PubMed
Publication date: 2025/12/12
Wu FeiShen JiannanZhao ZhitingChen YanRen BinhuiLi MingYin RongZhang YanyanYu Shaorong - The processes of absorption, distribution, metabolic action, and elimination (ADME) affect the advancement of cancer and the development of resistance to therapies. This study examined ADME-related genes in breast cancer (BRCA) mechanisms and their associations with BRCA. - Source: PubMed
Publication date: 2025/11/07
Yang YangYan LeiFeng YangLiu YulingShi GuangminHao Jiqing - The impact of the pandemic of SARS-CoV-2 infections in the population has caused many diseases onset, post the recovery. The most common is Cardiac injury, which causes further complications that lead to cardiovascular diseases (CVD). This study aimed to analyse the hub genes with a high correlation between SARS-CoV-2 and cardiovascular diseases.The datasets were obtained from the already available GSE196822, GSE196656, and GSE169241 data sets. DESec 2 in R was used for differentially expressed genes, and enriched pathway analysis was performed. Further, Cytoscape used the protein-protein interactions by STRING and hub genes for the common DEGs.The transcriptome analysis of GSE196822 revealed that 7,376 upregulated and 3,673 downregulated genes were the differentially expressed genes (DEGs) among the three selected datasets. Combining the overlap of these data sets for the common genes involved in COVID-19 and CVD, 169 upregulated and 123 downregulated DEGs were observed. These DEGs are further examined with GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes). The KEGG pathway revealed 21 upregulated and 11 downregulated pathways, where the highest count was recorded in transcriptional misregulations in cancer and metabolic pathways, respectively. The top 10 hub genes analysis and PPI network analysis revealed their interlinings for upregulation and downregulations, respectively. The top three upregulated genes (TIMP1, MPO, NFKBIA) and downregulated genes (ACSS1, OXCT1, ADHFE1) identified by differential expression analysis were validated by qRT-PCR, confirming their significant and consistent expression changes under the experimental conditions.The 9 out of 10 hub genes with elevated co-expressibility of linked genes between COVID-19 and CVD showed complications consistent with previous reports. Our findings further suggest that these hub genes may serve dual purposes: as indicators of early viral infection, including COVID-19 and related viral illnesses, and as potential predictors of cardiovascular disease (CVD) onset following COVID-19 infection. This work strongly urges health policymakers to implement screening for COVID-19 complications, especially CVDs, in the general public. - Source: PubMed
Publication date: 2025/09/23
Koyou Haily LiduinRamachandran VasudevanSalleh Mohd Nazil - Breast cancer (BC) is a significant malignancy characterized by a high global incidence and a propensity for recurrence. Absorption, distribution, metabolism, and excretion (ADME) genes comprise a collection of genes that participate in the drug ADME. Understanding the role and prognostic value of ARGs (ADME related genes) in BC advancement is critical for personalized therapy. Therefore, an ARPS (ADME related prognostic signature) was created in this study to examine the clinical implications of ARGs in patients with BC. - Source: PubMed
Publication date: 2025/06/04
Jin JieZhao XueyunDeng MiaoDu Lingyan