ADCYAP1
- Known as:
- ADCYAP1
- Catalog number:
- 001202A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADCYAP1
Related genes to: ADCYAP1
- Gene:
- ADCYAP1 NIH gene
- Name:
- adenylate cyclase activating polypeptide 1
- Previous symbol:
- -
- Synonyms:
- PACAP
- Chromosome:
- 18p11.32
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-02
- Date modifiied:
- 2016-10-05
Related products to: ADCYAP1
Related articles to: ADCYAP1
- Polybrominated diphenyl ethers (PBDEs) are neuroendocrine-disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterized by abnormal psychosocial functioning and is commonly comorbid with cognitive deficits and sensory abnormalities. Here, we used a mouse model with translationally relevant exposure to establish direct causal evidence that maternal transfer of a commercial mixture of PBDEs, DE-71, produces ASD-relevant behavioral and neuroendocrine deficits in male offspring. C57Bl6/N mouse dams were exposed to a commercial PBDE mixture, DE-71, via oral administration of 0 (vehicle control, VEH/CON), 0.1 (L-DE-71), or 0.4 (H-DE-71) mg/kg b.w./day for 10 weeks, spanning from 3 weeks prior to gestation through the end of lactation at postnatal day (PND) 21. Mass spectrometric analysis indicated a dose-dependent transfer of PBDEs (in ppb) to brains of F1 male offspring at PND 30, with reduction in levels by PND 110. DE-71-exposed adult F1 male offspring displayed ASD-relevant abnormal neurobehavioral phenotypes, including impaired social novelty preference (SNP) despite intact general sociability and exaggerated repetitive behavior. There were also milder effects on long-term social recognition memory (SRM). DE-71-exposed mice also displayed altered olfactory discrimination of social odors without altered odor preference for non-social odors, impaired novel object recognition memory, and reduced open field habituation relative to VEH/CON. However, no changes were observed in sensorimotor, anxiety-, or depressive-like behaviors. At the molecular level, DE-71-exposed males displayed deregulated gene markers of prosocial neuropeptides, oxytocin, vasopressin, and PACAP systems in hypothalamic and forebrain regions. Oxt was upregulated in the paraventricular nucleus (PVN); Avp was upregulated in the PVN and bed nucleus of the stria terminalis (BNST) but downregulated in the lateral septum (LS); Avp1ar and Adcyap1 were upregulated in the BNST; and Adcyap1r1 was upregulated in the PVN, supraoptic nucleus (SON), and BNST. Peripheral OXT was increased in L-DE-71 males, while no changes in plasma AVP were observed. These findings demonstrate that developmental PBDE exposure produces enduring behavioral and neuroendocrine phenotypes that resemble core domains of ASD, which may result from early neurodevelopmental reprogramming within central social and memory networks. - Source: PubMed
Kozlova Elena VGonzalez Gwendolyn MDenys Maximillian EBishay Anthony EGutierrez RobertoReid JackKrum Julia MLampel GregoryLuvsanravdan NaranRabbani Kayhon MTu JordanCampoy LuisAnchondo Laura MLuna Crystal NOlomi Duraan SMonarrez EduardoCarrillo ValeriaTran Jasmin DPlatt DamonKorde YashChinthirla Bhuvaneswari DBlaibel MaherKim SimonChompre GladysPhillips Allison LStapleton Heather MHenkelmann BernhardSchramm Karl-WernerCurras-Collazo Margarita C - Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly. ADCYAP1 encodes pituitary adenylate cyclase activating polypeptide (PACAP), which can exert neuroprotective effects in neurodegenerative diseases. This study aims to probe the specific function of in AD. - Source: PubMed
Publication date: 2026/07/11
Jiang YuxiYang Tianrun - Semen quality traits in chickens are critical indicators reflecting reproductive efficiency, breeding progress, and economic profitability in the poultry industry. Understanding the genetic architecture and enabling targeted genetic improvement of these traits are essential for enhancing poultry production efficiency. In this study, we estimated genetic parameters and performed weighted single-step GWAS for five semen traits in RIR chickens to reveal their genetic architecture and identify key candidate genes and QTLs associated with semen quality. The results showed that heritability estimates for SEVOL, SECON, SPMOT, SPABR, and SPCOUNT ranged from 0.097 to 0.322, indicating low to moderate heritability. 29 significant QTL regions and 12 candidate genes (NFKB1, UBE2D3, PPP3CA, EIF4E, H2AFZ, DOCK2, MTNR1A, TACC3, ADCYAP1, GFRA1, ABLIM1, and CASP7) associated with semen traits were identified by WssGWAS. These QTL regions were located on chromosomes 4 and 13 for SEVOL, chromosome 4 for SPMOT, and chromosomes 2 and 6 for SPABR. Interestingly, four prominent consecutive QTL regions were shared between SEVOL and SPMOT. These QTL were located at 59.83-61.43 Mb, explaining 11.55% and 16.33% of the genetic variance for SEVOL and SPMOT, respectively. The largest-effect SNPs within these four QTL intervals exhibited significant effects on both semen volume and sperm motility, and these markers could be used for marker-assisted selection of semen traits. This study provides further insights into the genetic architecture of chicken semen traits, improves our understanding of their molecular regulation, and identifies valuable QTL and candidate genes. These findings offer a scientific basis for genetic improvement and marker-assisted selection of semen quality. - Source: PubMed
Publication date: 2026/05/28
Tesfay Hailai HagosZhang XiaokeLi YunleiZong YunheMa ZhongHan XintongZhao YiPan ZitingMani Adamu IsaYang FujianZhang ZongyaoChen JimingSun YanyanChen Jilan - Menopause is characterized by the cessation of ovarian hormone production. During postmenopause, cisgender women face increased risks of obesity, cognitive decline, and mood disorder. Mood disorders are associated with exposure to chronic stress. We investigated the combined effects of a high-fat diet (HFD) and chronic stress exposure in a mouse model of menopause using 4-vinylcyclohexene diepoxide (VCD), a selective ovotoxicant that gradually depletes ovarian follicles and hormones. Starting at 6 months, 82 female WT C57BL/6 J mice received sesame oil or VCD (130 mg/kg i.p.) 5 days per week for 3 weeks. One month after injection, mice were fed either low-fat diet (LFD) or HFD for 8 weeks followed by 6 weeks of chronic variable mild stress (CVMS). Post-CVMS, mice were either processed for gene expression of the anterodorsal bed nucleus of the stria terminalis (adBNST) or behavior tests to assess cognitive and anxiety-related behaviors. Plasma samples were collected to analyze metabolic hormones and corticosterone levels. VCD-treated HFD-fed mice had higher fat and body mass, and elevated fasting glucose levels compared to controls and more pronounced avoidance behaviors and cognitive impairments. VCD-treated LFD-fed mice exhibited less exploration of novel objects and open spaces compared to sesame oil and HFD counterparts. VCD elevated corticosterone levels on LFD and increased BNST Adcyap1 (PACAP) gene expression on HFD. These findings highlight cognitive repercussions of estrogen deficiency and suggest a potential protective effect of a HFD against some of the adverse outcomes associated with menopause. Our study emphasizes the importance of considering dietary and hormonal interactions in the development of therapeutic strategies. - Source: PubMed
Publication date: 2026/05/14
Knox NadjaYasrebi AliCaramico DanielDenney Katherine AWiersielis KimberlySamuels Benjamin ARoepke Troy A - Bladder painsyndrome (BPS) is a disabling condition diagnosed clinically, characterised by marked heterogeneity in cystoscopic phenotype and treatment response. Molecular mechanisms remain incompletely defined, and no validated biomarkers currently support diagnosis or phenotypic stratification. The objective was to synthesise molecular evidence underpinning BPS and evaluate biomarker candidates relevant to phenotype-informed diagnostics. - Source: PubMed
Publication date: 2026/05/05
Kaltsa AnastasiaShendy Maged Morad FouadKyriazis Grigorios