ADCYAP1
- Known as:
- ADCYAP1
- Catalog number:
- 001202A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADCYAP1
Related genes to: ADCYAP1
- Gene:
- ADCYAP1 NIH gene
- Name:
- adenylate cyclase activating polypeptide 1
- Previous symbol:
- -
- Synonyms:
- PACAP
- Chromosome:
- 18p11.32
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-02
- Date modifiied:
- 2016-10-05
Related products to: ADCYAP1
Related articles to: ADCYAP1
- Bladder painsyndrome (BPS) is a disabling condition diagnosed clinically, characterised by marked heterogeneity in cystoscopic phenotype and treatment response. Molecular mechanisms remain incompletely defined, and no validated biomarkers currently support diagnosis or phenotypic stratification. The objective was to synthesise molecular evidence underpinning BPS and evaluate biomarker candidates relevant to phenotype-informed diagnostics. - Source: PubMed
Publication date: 2026/05/05
Kaltsa AnastasiaShendy Maged Morad FouadKyriazis Grigorios - Yueju pill (YJ), a classical Chinese medicine formula first documented in 'Danxixinfa by Zhu Danxi for treating "six stagnations" (Liu Yu: qi, blood, phlegm, fire, dampness, and food), has been clinically prescribed for mood disorders characterized by qi stagnation and depression for centuries. Despite its historical application for relieving emotional constraint (Yujie) and treating depressive disorders, the rapid antidepressant mechanism and molecular targets of YJ remain incompletely elucidated. - Source: PubMed
Publication date: 2026/04/23
Xing ShanPeng YuhanWang YanqinWu ChangyuHan MingzhiXie HuijunChen GangZhang Hailou - Yueju pill (YJ), a classical Traditional Chinese Medicine formula for "six stagnations", has long been used for mood disorders. We have previously demonstrated that YJ exerts rapid-onset antidepressant effects. However, the long-lasting antidepressant effects and its underlying neurobiological mechanisms remain elusive. - Source: PubMed
Publication date: 2026/04/13
Xing ShanPeng YuhanWong Nga-LeeWu ChangyuFu ZhenzhenTan JingwenXie HuijunChen GangZhang Hailou - G protein-coupled receptors (GPCRs) are key regulators of intercellular communication. One sub-family, named class B1 GPCRs, including the pituitary adenylate cyclase-activating polypeptide 1 receptor (PAC1R), is important for metabolic, cardiovascular, and endocrine functions. Currently, there is a wealth of structural data describing the active G protein-coupled state of class B1 GPCRs, and more limited information on inactive or intermediate states. Although these structures provide insight into conformational differences between different activation states, the receptor dynamics underpinning them remain largely unknown. Here, we employed hydrogen deuterium exchange mass spectrometry (HDX-MS) to investigate the dynamics of PAC1R across three distinct states: inactive (apo), intermediate (peptide agonist-bound), and fully active (peptide agonist and G protein-bound). This revealed dynamics of different states along the PAC1R activation pathway and deepens the understanding of class B1 GPCR dynamics and molecular mechanisms of receptor activation. - Source: PubMed
Publication date: 2026/02/24
Nettleton Theodore JFairweather CameronPiper Sarah JIshii KentaGarama Daniel JSexton Patrick MJosephs Tracy MWootten Denise - Alzheimer's disease (AD) is a progressive neurodegenerative age-related disorder characterized by widespread transcriptional deregulation across multiple brain regions. Among the molecular players involved, the transcription factors (TFs) can regulate the expression of AD-related peptides (β-amyloid and tau). We aim to unveil reconstructed TF-centered networks and their dynamics across multiple brain regions. In this study, we conducted an exhaustive differential gene expression analysis, reconstructed TF-TF-centered regulatory networks, and performed master-regulation analyses across multiple regions. We used bulk RNA-seq data from 2,229 post-mortem samples from the ROSMAP, MAYO, and MSBB cohorts. To place these regulatory programs in a disease-relevant context, we integrated protein-protein interaction (PPI) data, experimental TF-target data, and AD-associated genetic risk loci as a translational layer. We assessed TF-centered regulons for 1,605 TFs and identified 354 master-regulators (MR-TFs) across multiple brain regions, including the parahippocampal gyrus, temporal cortex, and cerebellum, which exhibited the highest numbers of regulons. Overall, regulons fell within a moderate size range (median 55 targets), rather than into extensive large networks. Novel MR-TFs, including ADCYAP1, TEAD2, BCL6, MAFF, NFKBIA, were consistently identified as MR-TFs across tissues in AD. Furthermore, GUCY1B1, RBFOX2, and MEF2C were found conserved in the parahippocampal gyrus, inferior frontal gyrus, and posterior cingulate cortex. Additionally, our work identified the well-known AD-related genes BIN1, EGFR, and SPI1 as MR-TFs, reinforcing their functional roles as susceptibility risk markers in AD. This work established an MR-TF-centered integrated regulatory network map of AD, revealing MR-TFs as factors that orchestrate gene deregulation in a region- and cell-context-dependent approach, and providing a robust foundation for mechanistic and translational investigations in neurodegeneration. - Source: PubMed
Publication date: 2026/02/23
Belém-Souza Marcella VitóriaBarra-Matos Gustavode Araújo Gilderlanio Santana