ADAMTSL3
- Known as:
- ADAMTSL3
- Catalog number:
- 001175A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTSL3
Related genes to: ADAMTSL3
- Gene:
- ADAMTSL3 NIH gene
- Name:
- ADAMTS like 3
- Previous symbol:
- -
- Synonyms:
- KIAA1233, punctin-2
- Chromosome:
- 15q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-21
- Date modifiied:
- 2015-11-09
Related products to: ADAMTSL3
Related articles to: ADAMTSL3
- Bladder cancer (BC) screening contributes to better patient outcomes. However, existing diagnostic methods for BC are not suitable for large-scale screening. Serum microRNAs (miRNAs) are expected to be simple, cost-effective, and non-invasive screening tools for BC. This study aims to identify whether relevant serum miRNAs as diagnostic markers for BC. - Source: PubMed
Publication date: 2026/01/26
Zhou HuimeiGe ZhenjianLin ShengjieWu YutongZhang PengwuLi XutaiZhao ZhengpingLai YongqingTao Lingzhi - Lower limb skeletal muscle mass is essential for maintaining physical function in older adults and serves as an early indicator of sarcopenia. This study aimed to characterize the polygenic architecture of low-lower limb skeletal muscle index (low-LSMI), identify underlying biological mechanisms, and develop a polygenic risk score (PRS). - Source: PubMed
Publication date: 2026/01/06
Liu MeilingPark Sunmin - Ambient air pollution contributes to chronic obstructive pulmonary disease (COPD), but the genetic factors that may influence susceptibility remain poorly defined. We conducted a genome-wide interaction analysis to identify genetic markers that may modify the association between air pollution and COPD. We analyzed data from 16,839 Canadian Longitudinal Study of Aging participants, including spirometry, genome-wide genotype data (645,625 single-nucleotide polymorphisms [SNPs]), and air pollution exposure estimates. COPD was defined as a forced expiratory volume in 1 second to forced vital capacity ratio (FEV/FVC) below the lower limit of normal. Annual average concentrations of particulate matter (PM), nitrogen dioxide (NO), and ozone (O), representing multi-year exposure estimates (2012-2015), were assigned to participants' residential postal code. Logistic regression models with SNP-by-air-pollutant interaction terms were applied, with a significant interaction threshold set at p < 7.74 × 10 after Bonferroni correction. Significant interactions were observed between PM and rs3762953 in CEP72/TPPP (P = 4.82 × 10) and rs72802672 in WFDC1 (P5.62 × 10). For NO, significant interactions were observed with rs2585043 near ADAMTSL3/SH3GL3 (P4.01 × 10), rs6809120 in ADAMTS9 (P4.53 × 10), rs6761941 near EPCAM-DT/CALM2 (P5.12 × 10), rs113083358 in DLG2 (P6.44 × 10), and rs17801230 near FASTKD2/CPO (P4.69 × 10). These loci map to genes involved in microtubule and ciliary function, extracellular matrix remodeling and protease regulation, airway inflammation and smooth muscle contractility, and mitochondrial function. These findings highlight genetic modification of the association between air pollution and COPD susceptibility in low-exposure settings and offer mechanistic insight without implying direct clinical application. - Source: PubMed
Publication date: 2026/01/20
Odimba UgochukwuFarrell JamieSadatsafavi MohsenJiang XiantaGao Zhiwei - The species Capra hircus encompasses numerous breeds that exhibit a high level of phenotypic and genetic variability, resulting from environmental adaptation and artificial selection for meat, milk, and fiber production. Today, the global domestic goat population is steadily increasing, primarily due to their ability to adapt to harsh environments. Their worldwide distribution offers the opportunity to study how different environmental conditions and farming systems have shaped the goat genome. In this work, 194 whole-genome sequencing data sets from wild, feral, and domestic goats have been used to detect Runs of Homozygosity (ROH) and study Extended Haplotype Homozygosity (EHH) to identify the so-called 'Signatures of Selection' that uniquely characterize each goat population. - Source: PubMed
Publication date: 2025/10/21
Pallotti StefanoGarcia Angie Fernanda RodriguezDeiana GiovanniAntonini MarcoZhou JunwenSun HaizhouRenieri CarloNapolioni Valerio - The anterior cingulate cortex (ACC) of the human brain is involved in higher-level cognitive functions such as emotion and self-awareness. We generated profiles of human and macaque ACC gene expression and chromatin accessibility at single-nucleus resolution. We characterized the conserved patterns of gene expression, chromatin accessibility, and transcription factor binding in different cell types. Combining the published mouse data, we discovered the molecular identities and cell-lineage origin of the primate von Economo neurons (VENs). Our in vitro and in vivo experiments identified a group of primate-shared and human-specific VEN marker genes, such as PCSK6, ADAMTSL3, and CDHR3, potentially contributing to VEN morphogenesis. We demonstrated that the human-specific sequence changes account for the cellular and functional innovations in the ACC during primate evolution and human origin. These findings provide new insights into understanding the cellular composition and molecular regulation of ACC and its evolutionary role in shaping human-owned higher cognitive skills. - Source: PubMed
Publication date: 2024/12/03
Yuan JiamiaoDong KangningWu HaixuZeng XueruiLiu XingyanLiu YanDai JiapeiYin JichaoChen YongjieGuo YongboLuo WenhaoLiu NaSun YanZhang ShihuaSu Bing