ADAMTS19
- Known as:
- ADAMTS19
- Catalog number:
- 001171A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTS19
Related genes to: ADAMTS19
- Gene:
- ADAMTS19 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 19
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-03-05
- Date modifiied:
- 2015-11-09
Related products to: ADAMTS19
Related articles to: ADAMTS19
- Intervertebral disc degeneration is associated with loss of nucleus pulposus (NP) cell phenotype and extracellular matrix, both processes linked to changes in cytoskeletal contractility and cell shape. Here, we tested whether microenvironment-specific modulation of RhoA signaling can restore NP-like morphology and gene expression in NP cells cultured in 2D and in 3D alginate. In 2D monolayer culture, where cells are spread and mechanically activated, pharmacologic inhibition of RhoA with CT04 reduced RhoA activity, decreased actomyosin contractility gene expression, and shifted morphology toward a smaller, more circular phenotype. Bulk RNA sequencing showed that CT04 treatment increased expression of NP phenotypic and matrix-related genes including , , , and while decreasing expression of catabolic and fibroblast-associated genes including and , consistent with enrichment of extracellular matrix pathways. In contrast, RhoA activation with CN03 in 2D culture increased actin and phosphorylated myosin light chain intensity but produced limited phenotypic improvement. In 3D alginate, which minimizes integrin-mediated adhesion, baseline actomyosin markers were reduced relative to 2D culture. In alginate, RhoA activation with CN03 increased the amount of actin, phosphorylated myosin light chain, and actomyosin gene expression, yet also promoted a more compact, circular morphology and increased NP markers, including and with repeated dosing. Across culture conditions, increased cell roundness was consistently associated with increased expression, indicating strong coupling between cytoskeletal state, morphology, and NP matrix programs. Together, these findings demonstrate that RhoA pathway perturbation can promote NP phenotypic gene expression in both 2D and 3D culture, but the direction of optimal modulation depends on the microenvironment, supporting RhoA signaling as a context-dependent therapeutic target for disc regeneration. - Source: PubMed
Publication date: 2026/04/07
Bond GabriellaKim Min Kyu MLisiewski LaurenJacobsen TimothyChahine Nadeen - The ADAMTS family are extracellular matrix (ECM) proteins and enzymes involved in regulating tissue structure and function. The ECM is a network of proteins and polysaccharides surrounding the cells that provide support and maintain cellular function. Mutations to proteins in the ECM lead to systemic connective tissue disorders by disrupting the structural integrity and maintenance of the ECM, resulting in ocular, musculoskeletal, skin, and cardiovascular abnormalities. Mutations that arise from the ADAMTS family lead to specific connective tissue disorders with distinct clinical characteristics. Here, we detail these distinct clinical features of major connective tissue disorders that arise from mutations in the ADAMTS family proteins. These include Ehlers Danlos syndrome arising from mutation in , Geleophysic Dysplasia from 2, Weill-Marchesani Syndrome from and , Ectopia lentis from , thoracic aortic aneurysms and dissection from , valvular disease in , and a further connective tissue disorder from mutations in This review details the mechanisms in which mutations to these genes impair the structure of the ECM, leading to the variety of phenotypic outcomes seen in connective tissue disorders. - Source: PubMed
Publication date: 2026/03/31
Alcocer Ana DRush Elizabeth HMead Timothy J - Autism spectrum disorder (ASD) has a complex genetic etiology, with limited data from Indian populations. This study delineates the genetic architecture of ASD in Indian children using whole exome sequencing (WES) and exploratory genetic association studies (GASs). - Source: PubMed
Publication date: 2026/01/21
Naushad Shaik MohammadEsdhan Basha ShaikKanaka Durga Devi Yadam ReddyPalanikumar PalanichamyKonanki Ramesh - In the original publication [...]. - Source: PubMed
Publication date: 2025/12/29
Jiang YingmingYu XihuZhao YandongHuang JintuanLi TuoyangChen HaoZhou JunyiHuang ZhenzeYang Zuli - Objective of this study is to conduct a genome-wide association study (GWAS) of first-parity reproductive traits in Suzi pigs to identify significant single-nucleotide polymorphisms (SNPs) or candidate genes influencing these traits. - Source: PubMed
Publication date: 2025/11/06
Fu YanfengLi WeiningDai ChaohuiLiao ChaoCheng JinhuaLi HuiZhao Weimin