ADAMTS16
- Known as:
- ADAMTS16
- Catalog number:
- 001168A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTS16
Related genes to: ADAMTS16
- Gene:
- ADAMTS16 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 16
- Previous symbol:
- -
- Synonyms:
- ADAMTS16s
- Chromosome:
- 5p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-13
- Date modifiied:
- 2016-10-05
Related products to: ADAMTS16
Related articles to: ADAMTS16
- The mandibular condyle is covered by fibrocartilage, and its degeneration, termed temporomandibular joint osteoarthritis (TMJOA), currently lacks effective disease-modifying therapies. In this study, we uncover a previously unrecognized mechanism by which the extracellular matrix protein TGFBI (TGF-β-induced) sustains condylar fibrocartilage homeostasis by restraining protein O-GlcNAcylation. We demonstrate that TGFBI is predominantly expressed in the condylar perichondrium and is markedly downregulated in both TMJOA patients and corresponding mouse models. Genetic ablation of Tgfbi delays postnatal skeletal development, promotes chondrocyte hypertrophy, and accelerates fibrocartilage degeneration. Mechanistically, TGFBI functions as a negative regulator of O-GlcNAcylation in condylar perichondrial cells (cPCs), thereby suppressing both the transcriptional activation and protein stability of the matrix protease ADAMTS16. Notably, ex vivo studies identify Ser1170 of ADAMTS16 as a critical O-GlcNAcylation site that directly governs its protein turnover. By inhibiting O-GlcNAcylation at this residue, TGFBI prevents condylar chondrocyte hypertrophy, senescence, and extracellular matrix degradation. Collectively, our findings establish the TGFBI-O-GlcNAcylation-ADAMTS16 axis as a vital driver of condylar fibrocartilage degeneration and highlight a promising metabolic target for TMJOA therapy. - Source: PubMed
Publication date: 2026/09/16
Liu XinLuo XinyueZhao JieJiang ZiyanZhai JiayiZhu TaominJia XuekeMa XiaohanJiang HenghuaLi HuiminFeng YapingKe JinLong Xing - As an important member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, ADAMTS16 participates in various physiological and pathological processes through the regulation of extracellular matrix (ECM) components. This review systematically delineates the expression profiles of ADAMTS16 in different tissues and cell types, as well as its diverse roles in reproductive development, cardiovascular diseases, ocular diseases, skeletal disorders, malignancies, and other pathological conditions, revealing significant differences in its expression patterns and mechanisms of action across various tissues. Cumulatively, current evidence suggests that ADAMTS16 may engage in direct or indirect interactions with ECM constituents to regulate cell proliferation, differentiation, and migration, and may also influence a range of cellular activities via synergistic cooperation with other cytokines. - Source: PubMed
Publication date: 2026/08/06
Wang LinxiuZhang JiazhenZhang Yuying - To examine associations of inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) with incident dementia and mortality, characterize proteomic and metabolomic correlates of carrier status, and evaluate whether these biomarkers relate to dementia and mortality risk. - Source: PubMed
Publication date: 2026/07/20
Beydoun May ASong MinkyoYun ChoaNoren Hooten NicoleWeiss JordanBeydoun Hind ADuggan Michael RWalker Keenan ALauner Lenore JEvans Michele KZonderman Alan B - Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the are matrix-associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and functional analysis of the ADAMTSs in OS, with particular focus on ADAMTS-3. Copy number alterations and mRNA expressions of ADAMTS genes were analyzed using the TCGA datasets. Gene set enrichment analysis and co-expression analyses identified biological processes associated with ADAMTS-3. Mechanistic studies investigated tumor necrosis factor-alpha (TNF-α) regulation of ADAMTS-3 in OS cells. Genomic profiling revealed frequent amplification and high mRNA expression of ADAMTS4, ADAMTS12, ADAMTS16, and ADAMTS17, indicating potential oncogenic activity. ADAMTS-3 was markedly overexpressed in OS tissues and cell lines, showing strong positive correlations with inflammatory (IL6, STAT3, NF-κB) and matrix-remodeling (MMP2, MMP9) genes. Functional enrichment indicated that ADAMTS-3 is associated with ECM organization, immune response regulation, and epithelial-mesenchymal transition. Mechanistically, TNF-α induced ADAMTS-3 transcription via activation of MEK, PI3K, JNK, and NF-κB pathways, with STAT3 and NF-κB by enhancing promoter activity. These findings identify ADAMTS-3 as an inflammation-responsive gene that links inflammatory signaling to ECM remodeling and tumor invasiveness in OS, representing a potential molecular bridge. - Source: PubMed
Publication date: 2026/05/03
Aymaz Ehed MuhammedAlper MeltemSav Feyza NurAydemir TuğşenKöçkar Feray - Renal fibrosis (RF) plays a crucial role in the transition from different forms of CKD to ESRD, recognized as the primary pathological change in chronic kidney disorders. Previous study demonstrated that Zhenwu decoction (ZWD) is efficacious in the treatment of RF whether initiated in the early or the late stage. To elucidate the molecular mechanisms of ZWD on RF treatment and to propose novel potential targets for therapeutic intervention in RF treatment, qualitative chemomics strategy was conducted to search the potential active compounds of ZWD by UPLC-Q-TOF/MS. And transcriptomic analysis and pathway enrichment was utilized to identify key regulatory genes and signaling involved in medicine and RF conditions. As a result, aconite alkaloids and paeoniflorin were identified as the principal pharmacodynamic constituents, while ADAMTS16 and TRPV5 emerged as novel targets of ZWD in the context of RF. Importantly, the robust expression of ADAMTS16 and TRPV5 in the kidney highlights their potential as therapeutic targets for RF. - Source: PubMed
Publication date: 2025/09/15
Ren XiaopengHong MeiqiDu LijingSun YuanfangHuang XinWang XiaoyingLi ShashaXiao Xue