ADAMTS16
- Known as:
- ADAMTS16
- Catalog number:
- 001168A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTS16
Related genes to: ADAMTS16
- Gene:
- ADAMTS16 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 16
- Previous symbol:
- -
- Synonyms:
- ADAMTS16s
- Chromosome:
- 5p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-13
- Date modifiied:
- 2016-10-05
Related products to: ADAMTS16
Related articles to: ADAMTS16
- Osteosarcoma (OS) is an aggressive bone malignancy characterized by genomic instability and extensive extracellular matrix (ECM) remodeling. Members of the are matrix-associated proteases implicated in tumorigenesis; however, their roles in OS remain poorly defined. This study provides a comprehensive genomic, transcriptomic, and functional analysis of the ADAMTSs in OS, with particular focus on ADAMTS-3. Copy number alterations and mRNA expressions of ADAMTS genes were analyzed using the TCGA datasets. Gene set enrichment analysis and co-expression analyses identified biological processes associated with ADAMTS-3. Mechanistic studies investigated tumor necrosis factor-alpha (TNF-α) regulation of ADAMTS-3 in OS cells. Genomic profiling revealed frequent amplification and high mRNA expression of ADAMTS4, ADAMTS12, ADAMTS16, and ADAMTS17, indicating potential oncogenic activity. ADAMTS-3 was markedly overexpressed in OS tissues and cell lines, showing strong positive correlations with inflammatory (IL6, STAT3, NF-κB) and matrix-remodeling (MMP2, MMP9) genes. Functional enrichment indicated that ADAMTS-3 is associated with ECM organization, immune response regulation, and epithelial-mesenchymal transition. Mechanistically, TNF-α induced ADAMTS-3 transcription via activation of MEK, PI3K, JNK, and NF-κB pathways, with STAT3 and NF-κB by enhancing promoter activity. These findings identify ADAMTS-3 as an inflammation-responsive gene that links inflammatory signaling to ECM remodeling and tumor invasiveness in OS, representing a potential molecular bridge. - Source: PubMed
Publication date: 2026/05/03
Aymaz Ehed MuhammedAlper MeltemSav Feyza NurAydemir TuğşenKöçkar Feray - Renal fibrosis (RF) plays a crucial role in the transition from different forms of CKD to ESRD, recognized as the primary pathological change in chronic kidney disorders. Previous study demonstrated that Zhenwu decoction (ZWD) is efficacious in the treatment of RF whether initiated in the early or the late stage. To elucidate the molecular mechanisms of ZWD on RF treatment and to propose novel potential targets for therapeutic intervention in RF treatment, qualitative chemomics strategy was conducted to search the potential active compounds of ZWD by UPLC-Q-TOF/MS. And transcriptomic analysis and pathway enrichment was utilized to identify key regulatory genes and signaling involved in medicine and RF conditions. As a result, aconite alkaloids and paeoniflorin were identified as the principal pharmacodynamic constituents, while ADAMTS16 and TRPV5 emerged as novel targets of ZWD in the context of RF. Importantly, the robust expression of ADAMTS16 and TRPV5 in the kidney highlights their potential as therapeutic targets for RF. - Source: PubMed
Publication date: 2025/09/15
Ren XiaopengHong MeiqiDu LijingSun YuanfangHuang XinWang XiaoyingLi ShashaXiao Xue - Male reproductive health is intricately linked to dietary components and gut microbiota balance. Osteopontin (OPN) deficiency and gut dysbiosis are associated with impaired spermatogenesis, yet the synergistic effects of probiotics and OPN remain unexplored. - Source: PubMed
Publication date: 2025/08/21
Zhao ChunyanGao GuangqiZhang TaoLi NaZhao YueLu ZerongZhang YongSun Zhihong - Yunong Black (YN) pigs and Yunong Black × Landrace (YL) hybrid pigs exhibit significant differences in meat quality characteristics. Studies have suggested that extrachromosomal circular DNA (eccDNA) may play a regulatory role in muscle development. In order to study the differences in eccDNA between two groups with different meat quality traits and their potential biological significance, this study used the Circle-seq method to detect eccDNA in the longest dorsal muscle (LDM) of Yunong Black pigs (YN) ( = 3) and Yunong Black × Landrace hybrid pigs (YL) ( = 3). EccDNA-related differentially expressed genes (eccDEGs) were then analyzed in combination with RNA-seq to explore the mechanisms by which eccDNA affects meat quality. The results showed that 1325 and 1304 differentially expressed eccDNAs were identified in the YN and YL groups, varying in size and distributed across multiple genomic functional regions. These eccDNAs were also annotated according to several protein-coding genes. Combined analysis with RNA-seq results revealed 19 and 27 eccDEGs in the YN and YL groups. The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analysis enriched many lipid-related pathways, such as chemokine signals and ADP metabolic processes. By constructing a regulatory network, several potential regulatory networks that might be related to pork quality, for example, ecc_sus_8665/ssc-miR-212/ADAMTS16, were identified. In summary, we identified several potential eccDNAs that may regulate pig muscle, offering insights into the regulation of pig muscle traits for breeding. - Source: PubMed
Publication date: 2025/05/29
Bai LiyaoWu JiahaoDou TengfeiChu DonghuiLi XinjianHan XueleiQiao RuiminWang KejunYang FengLi Xiuling - Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association studies have identified hundreds of associations for each glycaemic trait, yet very few studies have involved continental African populations. We report the results of genome-wide association studies (GWASs) in a pan-African cohort for four glycaemic traits, namely fasting glucose, fasting insulin, insulin resistance (HOMA-IR) and beta cell function (HOMA-B), which are quantitative variables that affect the risk of developing type 2 diabetes. - Source: PubMed
Publication date: 2025/03/01
Chebii Vivien JWade Alisha NCrowther Nigel JNonterah Engelbert AAgongo GodfredSimayi ZBoua Palwende RKisiangani IsaacRamsay MichèleChoudhury AnanyoSengupta Dhriti