ADAMTS9
- Known as:
- ADAMTS9
- Catalog number:
- 001162A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ADAMTS9
Related genes to: ADAMTS9
- Gene:
- ADAMTS9 NIH gene
- Name:
- ADAM metallopeptidase with thrombospondin type 1 motif 9
- Previous symbol:
- -
- Synonyms:
- KIAA1312
- Chromosome:
- 3p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-27
- Date modifiied:
- 2015-11-09
Related products to: ADAMTS9
Related articles to: ADAMTS9
- Obesity is an important risk factor for Type 2 Diabetes (T2D) as approximately 90% of T2D patients are obese. The single nucleotide polymorphisms (SNPs) rs4607103 (C˃T) in the ADAMTS9 gene and rs7578597 (T˃C) in the THADA gene were identified as two novel T2D risk loci. However, studies investigating the associations of these variants with T2D and obesity are limited, and little is known about the mechanisms underlying their association with T2D. Therefore, we aimed to evaluate the association between THADA and ADAMTS9 gene variants and T2D, taking into account the presence or absence of obesity. - Source: PubMed
Publication date: 2026/06/19
Erkoç-Kaya DuduArikoglu HilalGokturk FatmaIscioglu FundaIpekci Suleyman Hilmi - To investigate the association between genetic variants susceptible to exudative age-related macular degeneration (AMD) and the treatment response to as-needed intravitreal brolucizumab (IVBr) therapy. - Source: PubMed
Publication date: 2026/05/19
Yoneyama SeigoSakurada YoichiFukuda YoshikoShijo TaiyoKotoda YumiKikushima WataruMabuchi FumihikoKashiwagi Kenji - Analysis of runs of homozygosity (ROH) in commercial breed genomes is important for accurately assessing the population inbreeding status and exploring homozygous regions related to economic traits formed by selection pressure. The Danish Large White (LW) pig is a commercially important breed renowned for its superior growth efficiency and reproductive performance. In the present study, we identified ROH segments of Danish LW pigs based on 43 individual whole-genome resequencing data. We then calculated the inbreeding coefficient and screened candidate genes with important economic traits from the ROH islands. A total of 9446 ROH segments were identified in the LW pig population. Each LW pig carried 219.67 ROH. Most ROH were , and the average genomic inbreeding coefficient ( ) in LW pigs was 0.24. However, the proportion of ROH ( ) in LW pigs has reached 10 %, indicating selection pressure or inbreeding in recent times. Candidate genes related to reproductive traits (, , , , , , and ), and growth and development traits (, , , , , , , , , , and ) were identified in the genomic ROH islands of LW pigs. In conclusion, the present study provides further assessment of genetic diversity and inbreeding in the Danish LW pig population. In addition, our results provide useful insights into the functions of ROH on a hereditary basis and the role that ROH play in controlling the excellent characteristics of Danish LW pigs. - Source: PubMed
Publication date: 2026/01/12
Ding WeiminWu XudongBu YuZhang WeiWang YuanlangDing YueyunZheng XianruiZhang XiaodongYin Zongjun - Metastatic recurrence drives dismal survival in esophageal squamous cell carcinoma (ESCC), yet epigenetic mechanisms underlying metastasis remain poorly defined. While DNMT1 and DNMT3A contribute to ESCC pathogenesis, DNMT3B's role is enigmatic despite frequent dysregulation. - Source: PubMed
Publication date: 2026/03/06
Shen Fang-FangLi Dong-FenKong Ling-BeiLi Jia-LeMa Shi-LongJiang Hao-ZheYuan Hao-ZeJin YanChen Zhi-GuoGuo Xiu-JuanDong Gao-PanLu De-RongZhong Jia-Teng - The emergence and progression of a range of cardiovascular and cerebrovascular conditions are linked to endothelial dysfunction. Nevertheless, the specific pathways leading to damage in vascular endothelium remain to be elucidated. This study aimed to investigate the function and mechanisms of endothelial cell differentiation-related circular RNAs (circRNAs) in the differentiation of vascular endothelial cells. First, we screened for differentially expressed circRNAs (DECs) and genes (DEGs) during the differentiation of induced pluripotent stem cells (iPSCs) into endothelial cells, using human umbilical vein endothelial cells (HUVECs) as a reference model. Next, we predicted miRNAs associated with DECs and identified core genes related to the differentiation of stem cells into endothelial cells. Then, we verified the expression of endothelial cell differentiation-related circRNAs and the competing endogenous RNA (ceRNA) axis at the cellular and organoid level. Finally, we explored the ceRNA regulatory axis. Six core genes were initially identified, but we focused on a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9). At the cellular level, hsa_circ_0000010, hsa_circ_0005875, hsa_circ_0090122, and ADAMTS9 mRNA and protein levels were significantly increased in the HUVEC group, while hsa_circ_0000161, hsa_circ_0002824, hsa_circ_0074944, TXNIP mRNA, hsa-miR-548az-5p, and hsa-miR-548t-5p levels were significantly decreased compared to the iPSC group. At the organoid level, during the differentiation of stem cells into endothelial cells, hsa_circ_0090122 and ADAMTS9 mRNA and protein levels were increased, while hsa-miR-548az-5p and hsa-miR-548t-5p levels were decreased. Among the candidates, hsa_circ_0090122 and its related miRNAs (hsa-miR-548az-5p/hsa-miR-548t-5p) were prioritized because their expression changes were the most pronounced and directionally consistent with ADAMTS9, both in bioinformatic screening and validation experiments. Hsa_circ_0090122 may play a significant role in driving endothelial differentiation by regulating ADAMTS9 expression through competitive interaction with hsa-miR-548az-5p and hsa-miR-548t-5p. - Source: PubMed
Publication date: 2026/03/04
Sun YuYin ZhuonaHuang YidanChen YanjunYin HaoZhang YuanmeiJin Wen