ACYP1
- Known as:
- ACYP1
- Catalog number:
- 001120A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACYP1
Related genes to: ACYP1
- Gene:
- ACYP1 NIH gene
- Name:
- acylphosphatase 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-21
- Date modifiied:
- 2016-02-26
Related products to: ACYP1
Related articles to: ACYP1
- Liver fibrosis represents a pivotal histopathological stage in the progression of chronic liver disease toward cirrhosis, threatening millions of patients worldwide while therapeutic options remain scarce. Morroniside, an iridoid glycoside derived from Cornus officinalis, has been shown potent hepatoprotective properties, but its potential to attenuate liver fibrogenesis remains largely unexplored. - Source: PubMed
Publication date: 2026/07/31
Zhang CongSong YingyingHuang YurouLuo YingxiZhao HanHuang YaniZhao HaixiaQiu Zhenpeng - Lactation performance is a pivotal economic trait in sheep production, yet its underlying epigenetic regulatory mechanisms remain poorly understood. In the present study, we integrated ATAC-seq and RNA-seq to compare chromatin accessibility landscapes and transcriptomic in mammary gland tissues from Sewa sheep (SWS) and East Friesian sheep (EFS). Histological characterization revealed that SWS exhibited significantly smaller mammary acini area, smaller lipid droplet area, and reduced lipid droplet diameter compared to EFS. ATAC-seq analysis identified 15,902 differentially accessible regions (DARs) between the two breeds, with motif enrichment analysis uncovering key transcription factors potentially governing lactation traits. RNA-seq analysis revealed 1,163 differentially expressed genes (DEGs), which were involved in lactation regulation. Integrated analysis identified 441 overlapping genes, and enriched in glycolysis/gluconeogenesis (e.g., PGAM1, ENO1) and pyruvate metabolism (e.g., ACACA, ACSS1, ACYP1). Collectively, our study provides new insights into the epigenetic regulatory mechanisms underlying lactation performance differences in sheep. - Source: PubMed
Publication date: 2026/07/29
Li WentaoXu JiaminSheng JiashunLi PengboZhang ZuokeLuo XinSong TianzengFu TongGao TengyunZhang TianliuSun Yu - Trimethylamine n-oxide (TMAO) is a plasma metabolite linked to adverse cardiometabolic health with complex regulation involving diet, sex, and host genetics. We explored the role of these factors in the genetic regulation of TMAO by performing a primary-level meta-analysis in 1,482 female and male Diversity Outbred (DO) mice from five distinct studies conducted in various regions of the United States. We identified a quantitative trait locus (QTL) associated with TMAO concentration at ~86 megabase pairs on mouse chromosome 12 with a highly significant LOD score of 67.67. Alleles at the chromosome 12 QTL inherited from the Cast/EiJ (CAST) and PWK/PhJ (PWK) mouse strains primarily drove the association with reduced TMAO concentrations. The chromosome 12 QTL remained significant in sex-stratified analyses and the mode of inheritance appeared additive; furthermore, the QTL was regulated by sex-by-genotype and sex-by-diet interactions. Using a CAST/EiJ X C57BL/6J F2 cross, positional candidates were prioritized by eQTL analysis. Further analysis in a study utilizing the eight DO founding strains identified that was differentially expressed in hepatic tissue from CAST mice, prompting investigation into its genetic regulation. demonstrated relevant - and -regulation and was significantly correlated with TMAO and hepatic However, no significant relationships between and TMAO were identified in mice inactivated for or with AAV overexpression of in the liver. Genes within the chromosome 12 QTL have synteny with humans and may translate to the genetic regulation of human plasma TMAO concentrations and atherosclerosis. - Source: PubMed
Publication date: 2026/06/24
Sutton Kristen JEvans Levi WGertz Erik RBudke DawsonHuda NazmulYam PhoebeKim MyungsukRutkowsky JenniferShih DianaHartiala JaanaPomp DanielLusis Aldons JAllayee HoomanBennett Brian J - The activities and products of carbohydrate metabolism are involved in key processes of cancer. However, its relationship with hepatocellular carcinoma (HCC) is unclear. - Source: PubMed
Publication date: 2024/08/03
Huang Hong-XiangZhong Pei-YuanLi PingPeng Su-JuanDing Xin-JingCai Xiang-LianChen Jin-HongZhu XieLu Zhi-HuiTao Xing-YuLiu Yang-YangChen Li - The adverse effects of microgravity exposure on mammalian physiology during spaceflight necessitate a deep understanding of the underlying mechanisms to develop effective countermeasures. One such concern is muscle atrophy, which is partly attributed to the dysregulation of calcium levels due to abnormalities in SERCA pump functioning. To identify potential biomarkers for this condition, multi-omics data and physiological data available on the NASA Open Science Data Repository (osdr.nasa.gov) were used, and machine learning methods were employed. Specifically, we used multi-omics (transcriptomic, proteomic, and DNA methylation) data and calcium reuptake data collected from C57BL/6 J mouse soleus and tibialis anterior tissues during several 30+ day-long missions on the international space station. The QLattice symbolic regression algorithm was introduced to generate highly explainable models that predict either experimental conditions or calcium reuptake levels based on multi-omics features. The list of candidate models established by QLattice was used to identify key features contributing to the predictive capability of these models, with Acyp1 and Rps7 proteins found to be the most predictive biomarkers related to the resilience of the tibialis anterior muscle in space. These findings could serve as targets for future interventions aiming to reduce the extent of muscle atrophy during space travel. - Source: PubMed
Publication date: 2023/12/13
Li KevinDesai RiyaScott Ryan TSteele Joel RickyMachado MeeraDemharter SamuelHoarfrost AdrienneBraun Jessica LFajardo Val ASanders Lauren MCostes Sylvain V