ACTN1
- Known as:
- ACTN1
- Catalog number:
- 001096A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACTN1
Related genes to: ACTN1
- Gene:
- ACTN1 NIH gene
- Name:
- actinin alpha 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 14q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-08-21
- Date modifiied:
- 2019-04-23
Related products to: ACTN1
Related articles to: ACTN1
- We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions . normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). - Source: PubMed
Lu SongLi Li PingWhite John VZhang XiaoyingNwaneshiudu IfeyinwaNwaneshiudu AdaobiNtaoula NectariaGaughan JohnMonos Dimitri SLin Wan-LuSolomides Charalambos COleszak Emilia LPlatsoucas Chris D - Structural defects in the zona pellucida (ZP), caused by mutations in ZP genes, are a recognized cause of female infertility; however, their pathogenic mechanisms are not fully understood. Here, we investigated how two distinct ZP defects (complete absence and thinning) compromise fertility using Zp1 and Zp2 rat models. We found that ZP deficiency leads to stage-specific oocyte loss during early antral follicle development in vivo and arrests the maturation of fully grown oocytes in vitro, which also exhibit reduced diameter and mitochondrial dysfunction. From the secondary follicle stage onward, granulosa cells showed reduced proliferation, increased apoptosis, and impaired adhesion, culminating in a disorganized cumulus-oocyte complex morphology and disrupted steroidogenesis by the antral stage. Further analysis revealed that the specialized structures for oocyte-somatic cell interaction, namely transzonal projections and oocyte microvilli, were disorganized and reduced in number. This structural disruption was accompanied by a global perturbation of the bidirectional communication and physical adhesion network between the oocyte and its somatic niche, underscoring the ZP's essential role in organizing this functional microenvironment. At the molecular level, single-cell transcriptomic and protein analyses demonstrated that ZP deficiency induces a thinning of the oocyte cortical actin layer and dysregulation of cytoskeletal dynamics. This was associated with an upregulation of actin-regulating proteins, including TPM4 and ACTN1, and the engagement of focal adhesion-related pathways. The observed cortical actin disorganization provides a plausible mechanistic link to the concurrent abnormalities in microvilli and cell-cell adhesion. Collectively, our results establish the ZP as a critical structural scaffold that ensures oocyte cortical integrity and coordinates the surrounding somatic cell niche. Its disruption leads to a progressive failure in oocyte-somatic cell interaction and support, ultimately resulting in oocyte developmental impairment and loss. This study provides detailed mechanistic insights into the pathogenesis of ZP-related female infertility (particularly empty follicle syndrome). - Source: PubMed
Publication date: 2026/04/20
Liang ShoujingXiang WeixiQuan RupingSu JiayuLv ChaoHuang HualinXiao Hongmei - The ovary is a central female reproductive organ responsible for producing oocytes and secreting steroid hormones. To investigate the molecular similarities and potential evolutionary origins of the ovary across vertebrates, we integrated publicly available single-cell and single-nucleus transcriptomic data from nine species, including oviparous animals (fish and chicken) and viviparous mammals (mouse, rat, sheep, goat, yak, monkey, and human). - Source: PubMed
Publication date: 2026/04/14
Xue BailingLiu YajingZhou ChenDossybayev KairatBaatar NarantuyaYudin NikolayZhang LinweiYang JiLi MenghuaXu Songsong - Glioblastoma (GBM) is a highly aggressive brain tumor with a profoundly immunosuppressive tumor microenvironment (TME). Myeloid cells, especially tumor-associated macrophages, play a key role in immune evasion, yet regulators within tumor cells that shape myeloid-mediated immunosuppression remain poorly characterized. - Source: PubMed
Publication date: 2026/03/16
Ren JunweiLu JieZhang ZhuweiXing Weikang - Skeletal muscle is a central regulator of metabolic health, serving as the primary site of postprandial glucose uptake and playing a critical role in whole-body insulin sensitivity. Despite its importance, the molecular mechanisms governing muscle differentiation (myogenesis) and their modulation by metabolic interventions remain poorly defined. This study identifies the clathrin adaptor protein Picalm (phosphatidylinositol-binding clathrin assembly protein) as a novel regulator of myogenesis and investigates its regulation in response to exercise training and intermittent fasting. - Source: PubMed
Publication date: 2026/03/13
Gaugel JasminHaacke NeeleKuropka BennoJähnert MarkusRominger JuliaJonas WenkeSpeckmann ThiloRausch NiclasKleinert MaximilianWeigert CoraGarcia-Carrizo FranciscoSchulz Tim JEbner MichaelFreund ChristianSchürmann AnnetteVogel Heike