ACTG2
- Known as:
- ACTG2
- Catalog number:
- 001077A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACTG2
Related genes to: ACTG2
- Gene:
- ACTG2 NIH gene
- Name:
- actin gamma 2, smooth muscle
- Previous symbol:
- ACTL3, ACTA3
- Synonyms:
- ACTSG
- Chromosome:
- 2p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-07
- Date modifiied:
- 2019-01-10
Related products to: ACTG2
Related articles to: ACTG2
- This study aimed to evaluate the intestinal mucosal alterations in lambs naturally infected with at both histopathological and molecular levels, focusing on the relationship between infection severity and gene expression. A total of 24 lambs were categorized into four groups (control, mild, moderate, and severe) based on histopathological assessment of intestinal tissue sections. The tissues were examined for villus morphology, epithelial integrity, inflammatory cell infiltration, crypt morphology, and hyperemia. Additionally, the expression levels of , and genes were quantified using real-time PCR (qPCR). Histopathological examination revealed progressive villus atrophy, epithelial degeneration, crypt hyperplasia, and lymphoplasmacytic infiltration in the lamina propria, which intensified with infection severity. Molecular analysis showed significant upregulation of and in the mild and moderate groups, suggesting early activation of mucosal repair. In contrast, expression decreased in the moderate and severe groups, indicating impaired epithelial detoxification. expression was significantly elevated across all infected groups, reflecting a compensatory response to tight junction disruption, while expression remained unchanged. infection in lambs induces complex mucosal pathogenesis. The results demonstrate that the disease involves a simultaneous activation of destructive and regenerative molecular mechanisms, with distinct gene expression patterns correlating with the severity of intestinal damage. - Source: PubMed
Publication date: 2026/06/22
Kenar Zeynep ÇelikÇifçi Ayşenur TuralDağar OsmanTuzcu NevinKaracan HüseyinTuzcu Mehmet - This research letter expands the phenotypic spectrum of ACTG2-associated autosomal dominant visceral myopathy to include isolated uterine involvement based on a case of an individual harboring a known pathogenic ACTG2 variant with uterine atony as her only symptom. - Source: PubMed
Publication date: 2026/08/20
Slater Brady AMuth EmilyMeeks Naomi J L - Atypical femoral fractures (AFFs) are stress-type insufficiency fractures classically associated with long-term bisphosphonate therapy in adults. Reports of AFFs in pediatric patients are limited primarily to osteogenesis imperfecta or other monogenic bone disorders following prolonged exposure. We report the first case of an AFF occurring after zoledronic acid administration in a child with ACTG2 gene mutation-related intestinal failure and severe metabolic bone disease. - Source: PubMed
Bhasin KaranvirZhang WilliamBansal RohitSingh JaskaranLaxdal Ian - Megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is a rare congenital visceral myopathy characterized by severe gastrointestinal dysmotility and bladder dysfunction, most commonly associated with mutations. - Source: PubMed
Publication date: 2026/07/27
Amato TommasoCantagalli Michele MariaDi Mitri MarcoColetta RiccardoMorabito Antonino - Analysis of stage transition in gastric cancer is the aim of this project. - Source: PubMed
Publication date: 2026/05/02
Montazer FatemehRezaei-Tavirani MostafaArjmand BabakAsri NastaranRazzaghi ZahraRazi FaridehBandarian Fatemeh