ACTBL2
- Known as:
- ACTBL2
- Catalog number:
- 001062A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACTBL2
Related genes to: ACTBL2
- Gene:
- ACTBL2 NIH gene
- Name:
- actin beta like 2
- Previous symbol:
- -
- Synonyms:
- DKFZp686D0972
- Chromosome:
- 5q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-08
- Date modifiied:
- 2019-03-21
Related products to: ACTBL2
Related articles to: ACTBL2
- Due to a lack of information related to molecular changes in heroin use, we aimed to examine heroin-dependent alterations in different regions of the post-mortem human brain. Tissues were obtained from males (n = 24 heroin users, n = 24 controls) through the Turkish Forensic Medicine Institute after structured verbal interviews with the relatives of the deceased to gather history of substance use. Following toxicological confirmation of heroin use, the hippocampus, putamen, and caudate nucleus were dissected from the left hemispheres. Proteomic analyses were performed using a high-resolution liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) system. Label-free quantitative analysis revealed significant differential expression of 87 proteins in the hippocampus, 121 proteins in the putamen, and 80 proteins in the caudate nucleus compared to controls. These differentially expressed proteins (DEPs) were subsequently used to construct protein-protein interaction (PPI) networks using the STRING database, revealing significantly enriched and highly interconnected interaction networks in all three regions. Gene Ontology (GO) enrichment analysis of DEPs consistently identified extracellular exosome, extracellular space, and vesicle as the top three cellular components. Molecular function enrichment further indicated alterations in signaling, binding, and stress-related processes. The expression of TST, RYR2, ACTBL2, and RPS27 decreased, whereas the expression of COL4A2, OGN, PMP2, and MAP2K6 increased in the hippocampus. In the putamen, the most prominent increases were observed in DNM2 and MADD expression. In the caudate nucleus, the expressions of RPS6KA2, TMED10, and NBEA proteins decreased, whereas HPX protein expression increased. Overall, these alterations promote oxidative stress and molecular changes linked to neurodegeneration, which likely contribute to impaired neuronal function and synaptic plasticity. - Source: PubMed
Publication date: 2026/02/21
Sürmen Mustafa GaniPence SadrettinSürmen SaimeBuyuk YalcinKuras SibelElibol BirsenPence Halime Hanim - Primary membranous nephropathy (PMN) is one of the leading causes of nephrotic syndrome in adults, but reliable prognostic assessment tools remain limited. Although traditional clinical parameters and serum anti-PLA2R antibodies constitute cornerstones of prognosis assessment, they fail to fully capture the heterogeneity of PMN treatment responses. Identification of multidimensional prognostic risk factors facilitates further guidance for treatment in PMN patients. This study aimed to identify novel urinary protein signatures predictive of clinical remission and delineate molecular subtypes associated with relapse.. - Source: PubMed
Publication date: 2025/12/11
Zeng LingyunSun YuxiangLiang TiantianTang HuaYe ZengchunHan TongHu ZhaoyongPeng Hui - Loiasis, caused by the filarial nematode Loa loa, imposes a significant disease burden in endemic regions in West and Central Africa. Manifestations include adult worms in soft tissue (e.g., the conjunctiva of the eye) and microfilaria in peripheral blood, with clinical presentations ranging from asymptomatic infections to life-threatening organ involvement. Diagnosis remains challenging due to variable microfilaria counts, frequent amicrofilaremic occult infections, and unreliable serological tests. The untargeted plasma proteome reflects broad (patho-)physiological responses, providing valuable insights into the host and disease. - Source: PubMed
Dierks ClemensTober-Lau PinkusVeletzky LuziaWang ZiyueZühlke BorisLudwig DanielaNiewienda AgatheFreiwald AnjaBardtke LaraKroneberg PaoloStelzl DanielHergeth JenniferManego Rella ZolekoMombo-Ngoma GhyslainAgnandji Selidji TodagbeAdegnika Ayola AkimMülleder MichaelRamharter MichaelRalser MarkusKurth Florian - The brown seaweed Laminaria digitata, known for its prebiotic qualities, and alginate lyase supplementation, may improve the growth and development of piglets during the critical post-weaning phase. The purpose of this study was to ascertain the effects of 10 % L. digitata and 0.01 % alginate lyase on the proteome and metabolome of the longissimus lumborum muscle in weaned piglets. Findings suggest that the enzyme supplement has a marginal effect on muscle proteome compared to the seaweed diet alone when compared to the control. L. digitata increased the prevalence of proteins related to muscle contraction and structure (such as ACTBL2), while it decreased the presence of glycolytic proteins (like GPI and ALDOC). It also increased the abundance of proteins related to the negative regulation of insulin receptor pathways, such as RABGAP1 and TSC2. Conversely, alginate lyase increased the abundance of proteins associated with fatty acid oxidation (ALOXE3) and calcium balance (WFS1), reflecting the impacts of dietary n-3 polyunsaturated fatty acids and lower calcium in the diet. As for the muscle metabolome, it remained mostly unchanged by dietary treatments, except for mannitol and threonine, which were enriched as a consequence of seaweed inclusion. - Source: PubMed
Publication date: 2025/04/04
Ribeiro David MSacarrão-Birrento LauraLeclercq Céline CCharton Sophie A BCosta Mónica MCarvalho Daniela F PSergeant KjellCocco EmmanuelleRenaut JennyFreire João P BPrates José A Mde Almeida André M - Schizophrenia is a severe psychological disorder. The current diagnosis mainly relies on clinical symptoms and lacks laboratory evidence, which makes it very difficult to make an accurate diagnosis especially at an early stage. Plasma protein profiles of schizophrenia patients were obtained and compared with healthy controls using 4D-DIA proteomics technology. Furthermore, 79 DEPs were identified between schizophrenia and healthy controls. GO functional analysis indicated that DEPs were predominantly associated with responses to toxic substances and platelet aggregation, suggesting the presence of metabolic and immune dysregulation in patients with schizophrenia. KEGG pathway enrichment analysis revealed that DEPs were primarily enriched in the chemokine signaling pathway and cytokine receptor interactions. A diagnostic model was ultimately established, comprising three proteins, namely, PFN1, GAPDH and ACTBL2. This model demonstrated an AUC value of 0.972, indicating its effectiveness in accurately identifying schizophrenia. PFN1, GAPDH and ACTBL2 exhibit potential as biomarkers for the early detection of schizophrenia. The findings of our studies provide novel insights into the laboratory-based diagnosis of schizophrenia. - Source: PubMed
Publication date: 2024/06/10
Shen Hui-PingDong XiaotaoLi Zhi-BinWu Jing-ZhuZheng Chun-MeiHu Xie-JunQian ChaoWang Sheng-PangZhao Yu-LongLi Ji-Cheng