ACTA2
- Known as:
- ACTA2
- Catalog number:
- 001060A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACTA2
Related genes to: ACTA2
- Gene:
- ACTA2 NIH gene
- Name:
- actin alpha 2, smooth muscle
- Previous symbol:
- -
- Synonyms:
- ACTSA
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-07
- Date modifiied:
- 2019-04-23
Related products to: ACTA2
Related articles to: ACTA2
- Mammary myofibroblastoma (MFB) is a rare benign mesenchymal tumor of the breast with myofibroblastic differentiation. Its diverse morphological spectrum may pose diagnostic challenges, particularly in limited biopsy specimens. All MFB patients diagnosed at a tertiary care center between 2015 and 2024 were reviewed retrospectively. Eleven patients were identified, including 7 women and 4 men, with a mean age of 56.5 years (range: 31-75 years). All patients presented with a solitary, painless breast mass. Tumor size ranged from 2.3 to 14 cm. Histologically, 9 tumors showed spindle cell morphology, whereas 2 showed epithelioid features. The common findings included short intersecting fascicles of bland spindle cells, variable collagen deposition, ectatic blood vessels, and focal adipocytic components. Immunohistochemically, CD34 was positive in 9 tumors, desmin in 8, smooth muscle actin (ACTA2) in 5, BCL2 and CD99 in 7 each, and CD10 in 4 tumors. Keratin AE1/AE3, p63, S100, and STAT6 were negative in all tumors. Follow-up data was available in 9 patients and no recurrence was reported. Recognition of its characteristic morphological and immunohistochemical features is essential to avoid diagnostic pitfalls. Complete surgical excision is curative, with an excellent prognosis. - Source: PubMed
Publication date: 2026/09/24
Naveed HaniaIdrees RomanaSafdar FatimaDin Nasir UdKayani Naila - Gene polymorphism in G protein-coupled receptor 35 () is associated with primary sclerosing cholangitis (PSC). How contributes to PSC pathogenesis remains poorly understood. We have observed infiltration of GPR35-positive mast cells in PSC explant liver tissue. Here, we aim to characterize dependent mast cell biology relevant for cholangitis and biliary fibrosis. - Source: PubMed
Publication date: 2026/09/21
Rønneberg Jørgen DChung Brian KJiang XiaojunElias Joshua EKarlsen Tom HKaneider Nicole CHov Johannes RSchneditz Georg - Coronary artery disease (CAD) may progress to ischemic cardiomyopathy (ICM) and heart failure through maladaptive cardiomyocyte remodeling and myocardial fibrosis. This study aimed to identify key molecular mediators linking inflammatory and fibrotic signaling during this pathological transition. - Source: PubMed
Publication date: 2026/09/11
Chen KexinHe XingyuNing XiangmingWang YaoLi NaHu TengMa ZeyuanYang FengruiZhang YinleiMa JunShi Zheng - Hypoxia-inducible factor-1α (HIF-1α) has emerged as a promising target for enhancing wound healing. Here, we conducted a systematic review to evaluate the efficacy of HIF-1α in improving wound healing. - Source: PubMed
Publication date: 2026/09/17
Chowdhury Mirza Farhana IqbalYazdani AmidIqbal AnumRahman AfrozaSaeed Tanzeela SameenSaeed Muhammad RamishAskar AbubakarAbraham John MHarmon John W - The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is essential for antiviral immunity, and its dysregulation causes inflammatory disease. The mechanism underlying STING activation, including its essential endoplasmic reticulum-to-Golgi translocation, has remained elusive. Here, we identify a dedicated actin-based transport system licensed by the smooth muscle actin isoform ACTA2 via in vitro reconstitution. Superresolution live imaging reveals STING becomes punctate and activated while moving along ACTA2 filaments. This ACTA2-directed network is required for antiviral interferon responses against HSV-1. Strikingly, it also drives pathological interferon production and lethal autoimmunity in mice, where its genetic or pharmacological disruption rescues disease. Furthermore, ACTA2 expression correlates with proinflammatory cytokine levels in peripheral blood mononuclear cells from systemic lupus erythematosus patients, and its downregulation ameliorates this inflammatory signature. Our work defines a specific cytoskeletal network that governs STING-dependent inflammatory responses to both foreign and self-DNA, thereby establishing stimulus-directed organelle trafficking as a central control point in innate immune signaling. - Source: PubMed
Publication date: 2026/09/15
Hou XiantengWu QingDu YangtingWang ChangwanZhu JunyanJiang YingboChen SheZhou LishaWu XiaoyuWang HongyanYang HuiHou Fajian