ACTA1
- Known as:
- ACTA1
- Catalog number:
- 001059A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACTA1
Related genes to: ACTA1
- Gene:
- ACTA1 NIH gene
- Name:
- actin alpha 1, skeletal muscle
- Previous symbol:
- ACTA
- Synonyms:
- NEM3
- Chromosome:
- 1q42.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: ACTA1
Related articles to: ACTA1
- Congenital myopathies (CMs) are a heterogeneous group of rare or ultra-rare inherited muscular disorders in which cognitive, neuropsychological and psychosocial outcomes remain poorly characterized. - Source: PubMed
Publication date: 2026/08/06
Rinella SergioAnastasio GennaroSapuppo AnnamariaBianco Manuela LoLeonardi RobertaPavone PieroRuggieri MartinoPolizzi Agata - Obesity-induced ectopic lipid accumulation inside skeletal muscle (SKM) (myosteatosis) and the liver (hepatosteatosis) contributes to local metabolic dysfunction and serves as a launchpad for the progression of diabetes. While stearoyl-CoA desaturase 1 (SCD1), an ER-bound enzyme that catalyzes the rate-limiting step in monounsaturated fatty acid (MUFA) synthesis, is widely recognized as a lynchpin facilitator of steatosis, much controversy exists on its efficacy as a therapeutic target. In particular, a total lack of SKM-specific SCD1 KO models has greatly limited our understanding of SCD1-mediated myosteatosis' relative contribution to metabolic syndrome. - Source: PubMed
Publication date: 2026/08/03
Guilfoyle-Speese AndrewBridgewater CodyPadgett CalebSellars HunterMintz JamesFulton DavidStepp David - Triploid fish have attracted considerable attention in aquaculture because of their sterility and rapid growth. In this study, a novel allotriploid fish (WA, 3 = 150) was obtained through distant hybridization of a female diploid hybrid fish (WR-II, 2 = 100) with a male allotetraploid fish (4nAT, 4 = 200). The measurable traits of WA exhibit significant differences from WR-II and its original parents (white crucian carp (WCC) and red crucian carp (RCC)). WA muscles exhibited higher protein, fat, and essential amino acid levels but lower moisture. Furthermore, WA enhanced growth performance and muscle hypertrophy compared to WCC and RCC. The transcriptomes and metabolomics of the muscle tissues of WA, WCC, and RCC were analyzed. In total, 3889 and 1863 differential expressed genes (DEGs) were identified in WA vs. WCC and WA vs. RCC, respectively. These DEGs were mainly enriched in pathways related to amino acid biosynthesis and oxidative phosphorylation. In total, 421 and 304 differential metabolites (DMs) were identified in WA vs. WCC and WA vs. RCC, respectively. These DMs were mainly enriched in the pathways related to glycerophospholipid and fatty acid metabolism. Integrated transcriptomic and metabolomic analyses revealed that the expression patterns of , , , and were associated with changes in the abundance of oleoyl ethanolamide, betaine, inosine, docosahexaenoic acid (DHA), and PC (38:6), suggesting their potential involvement in the enhanced growth performance of WA. This study provides a potential genetic resource for aquaculture and identifies molecular features associated with enhanced growth performance in this allotriploid fish. - Source: PubMed
Publication date: 2026/08/01
Liu FangleiYang HuirongLiu HongwenHuang ZiyiZhang XuanyiLi BeiDuan LujiaoYu JianmingHuang SiyangLiu QizhiTao MinZhang ChunLiu QingfengLiu Shaojun - Fibromatosis-like metaplastic carcinoma (FLMC) of breast is a rare neoplasm that exhibits distinct low-grade cytomorphology, a tendency for local recurrence and a favorable prognosis. This retrospective study aimed to evaluate the clinicopathological and immunohistochemical features of FLMC and assess its clinical behavior. Six female patients with histologically confirmed FLMC were included. Hematoxylin and eosin-stained slides were reviewed, and immunohistochemistry for keratin AE1/AE3, keratin CAM5.2, keratin 5/6, p63, EMA, ACTA1, desmin, and CD34 was performed. The mean age was 57.3 years, and all patients presented with a painless breast mass. Tumors were firm, unencapsulated, and averaged 4.9 cm in size on gross examination. Microscopically, they showed bland spindle cells in fascicular and storiform patterns with infiltrative borders. All tumors were positive for keratin AE1/AE3, keratin CAM5.2, and p63. EMA was positive in 1/3 tumors, keratin 5/6 in 3/3, ACTA1 in 2/3. All tumors were negative for desmin and CD34. No nodal metastasis was identified. On follow-up, one patient developed bone metastasis after 2 years, while the others remained disease-free 3 years post-surgery. FLMC is a rare low-grade epithelial malignancy that can mimic benign spindle cell lesions, making immunohistochemistry essential for diagnosis. Complete surgical excision with clear margins is curative in most patients. - Source: PubMed
Publication date: 2026/06/06
Naveed HaniaIdress RomanaEhsan MaidhaDin Nasir UdKayani Naila - Skeletal muscle actin forms the core structural component of thin filaments, which interact with thick filaments to generate contractile force. In addition to force production, the character of muscle contraction activity itself is thought to provide mechanical cues that influence synaptic development and maturation. In mouse skeletal muscle there is an early post-natal switch from embryonic forms of actin to the adult isoform, ACTA1, which increases both filament stability and force production. Newborn mice deficient for ACTA1 ( ), although initially able to breath, move and suckle, develop profound muscle weakness and die during the early neonatal period, despite a compensatory, increase in expression of embryonic actins. We took advantage of this to better understand the response of the neuromuscular junction (NMJ) to a disruption in contractility and activity-dependent signaling during development. Morphological analyses of the diaphragm in mice revealed that the patterning and formation of the NMJ proceed normally through postnatal day 5 (P5), the day at which pups begin to die. Short-term synaptic plasticity, assessed as the endplate potential (EPP) response to paired-pulse stimulation, was also unchanged, indicating normal presynaptic release of neurotransmitters. In contrast, electrophysiological recordings demonstrated significantly prolonged rise and decay kinetics of miniature and evoked endplate potentials, indicating altered postsynaptic receptor properties. Consistent with these functional changes, quantitative real-time PCR showed a reduced ratio of ε- to γ-acetylcholine receptor (AChR) subunit mRNA, reflecting a delay in the developmental switch from embryonic γ-containing to adult ε-containing AChRs. Together, these findings indicate that α-skeletal actin is dispensable for early NMJ morphogenesis but is required for timely postsynaptic receptor maturation, demonstrating a critical role for muscle contractile activity in coordinating synaptic development at the NMJ. - Source: PubMed
Publication date: 2026/05/26
Liu YunYe QiaohongLin Weichun