ACSS1
- Known as:
- ACSS1
- Catalog number:
- 001056A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACSS1
Related genes to: ACSS1
- Gene:
- ACSS1 NIH gene
- Name:
- acyl-CoA synthetase short chain family member 1
- Previous symbol:
- ACAS2L
- Synonyms:
- dJ568C11.3, AceCS2L, MGC33843
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-17
- Date modifiied:
- 2019-03-22
Related products to: ACSS1
Related articles to: ACSS1
- Plane of nutrition influences animal growth rate and muscle fiber composition, potentially through altering skeletal muscle metabolism. The objective of this study was to evaluate changes in skeletal muscle metabolism in response to altering diet without changes in growth rate. To that end, cattle were fed high-concentrate diets typically used in commercial feedlots until they reached market weight, approximately 604 kg. Cattle were then placed on isocaloric, maintenance diets consisting of primarily grain and forage diets for 60 d until harvest. Cattle fed a forage-based maintenance diet had increased mitochondrial succinate dehydrogenase (SDHA, P < 0.05), citrate synthase (CS, P < 0.01), electron transport chain complex I (CI, P < 0.01), complex II (CII, P < 0.01), and voltage dependent anion channel (VDAC, P < 0.001) protein abundances. Mitochondrial oxygen consumption rate was greatest in muscle mitochondria of forage-fed cattle when provided glutamate/malate (P < 0.05), acetoacetate/malate (P < 0.01), and palmitoyl-carnitine/malate (P < 0.05). This increased function is partially explained by increases in the abundance of electron transport chain complexes and the voltage-gated dependent anion channel (VDAC, P < 0.01), the pore allowing ATP to leave the mitochondria. Significant interaction between diet and muscle were noted for ACSS1 (P < 0.01) gene expressions. Additionally, forage-maintained cattle had increased ACSS1 (P < 0.01), CPT1b (P < 0.05), and CPT2 (P < 0.05) gene expression when compared to grain-maintained cattle. These data suggest part of the mechanism responsible for altered mitochondrial function in response to altered substrate availability may lie in the regulation of ACSS1, CPT1b, and CPT2 gene expressions for acetate and fatty acid metabolism. Together, diet influences muscle acetate and fatty acid gene expressions, mitochondrial protein abundances, and mitochondrial function in fatty acid substrate oxidation, highlighting the role of nutrition on skeletal muscle metabolism and possibly as a means of regulating tissue growth. - Source: PubMed
Publication date: 2026/08/27
Yen Con-NingBodmer Jocelyn SWicks Jordan CBeline MarianeZumbaugh Morgan DWilson Thomas BSilva Saulo LuzHanigan Mark DGerrard David E - Polycystic ovary syndrome (PCOS) is associated with metabolic disturbances within the follicular microenvironment that may impair oocyte competence. Although elevated acetate levels have been reported in the follicular fluid (FF) of PCOS patients, its metabolic fate and transcriptional impact in cumulus cells (CCs) remain unclear. This study investigated acetate-related metabolic reprogramming in CCs of women with PCOS. - Source: PubMed
Publication date: 2026/08/08
Safaeinejad ZahraValipour Motlagh AliRazavi FatemehEsmaeili MaryamRezvanian ParsaGhaedi-Heydari RasoolGhaderi Khorasgani AtefehDastjerdi SamaNasr-Esfahani Mohammad Hossein - Lactation performance is a pivotal economic trait in sheep production, yet its underlying epigenetic regulatory mechanisms remain poorly understood. In the present study, we integrated ATAC-seq and RNA-seq to compare chromatin accessibility landscapes and transcriptomic in mammary gland tissues from Sewa sheep (SWS) and East Friesian sheep (EFS). Histological characterization revealed that SWS exhibited significantly smaller mammary acini area, smaller lipid droplet area, and reduced lipid droplet diameter compared to EFS. ATAC-seq analysis identified 15,902 differentially accessible regions (DARs) between the two breeds, with motif enrichment analysis uncovering key transcription factors potentially governing lactation traits. RNA-seq analysis revealed 1,163 differentially expressed genes (DEGs), which were involved in lactation regulation. Integrated analysis identified 441 overlapping genes, and enriched in glycolysis/gluconeogenesis (e.g., PGAM1, ENO1) and pyruvate metabolism (e.g., ACACA, ACSS1, ACYP1). Collectively, our study provides new insights into the epigenetic regulatory mechanisms underlying lactation performance differences in sheep. - Source: PubMed
Publication date: 2026/07/29
Li WentaoXu JiaminSheng JiashunLi PengboZhang ZuokeLuo XinSong TianzengFu TongGao TengyunZhang TianliuSun Yu - Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by stenosis or occlusion of the terminal portions of the internal carotid arteries and their proximal branches, accompanied by the formation of abnormal collateral vessel networks. It represents a leading cause of ischemic and hemorrhagic stroke in both pediatric and adult populations. However, a comprehensive understanding of the molecular drivers underlying the hallmark vascular pathology of MMD remains elusive. Emerging evidence indicates that dysregulated lipid metabolism significantly contributes to MMD susceptibility and disease severity; nevertheless, its precise mechanistic roles in MMD pathogenesis have not been thoroughly investigated. - Source: PubMed
Publication date: 2026/06/09
Lu ZhenweiQiu XianshengZhou LiweiLi XiaodongLu HanwenWang ShuoChen JunfuBian LifeiLin JianbinZhao WenpengZhao WujieGao XinZhang JinsenChen SifangLi ZhangyuWang Zhanxiang - Lipid metabolism is closely related to aging, and its disorders can lead to obesity, insulin resistance, cardiovascular diseases, and various other conditions. The accumulation of lipids caused by increased lipid synthesis is key in the development of obesity, but the molecular mechanisms of increased lipid synthesis remain to be thoroughly studied, especially in the context of aging. In this work, we used in vivo and in vitro models to demonstrate that the long noncoding RNA Lncbate1 contributes to obesity by promoting lipid accumulation. Specifically, Lncbate1 increases lipid synthesis by downregulating the expression of miR-455-5p to increase the expression of the lipid synthesis gene ACSS1. Our findings highlighted Lncbate1 as a likely target for the intervention of aging-related obesity. - Source: PubMed
Publication date: 2026/06/19
Chen JingYang NingZhang YifanYao QianqianYuan Chengfu