ACSM5
- Known as:
- ACSM5
- Catalog number:
- 001055A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACSM5
Related genes to: ACSM5
- Gene:
- ACSM5 NIH gene
- Name:
- acyl-CoA synthetase medium chain family member 5
- Previous symbol:
- -
- Synonyms:
- FLJ20581
- Chromosome:
- 16p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2017-06-13
Related products to: ACSM5
Related articles to: ACSM5
- Long-term spaceflight poses substantial challenges to human physiology, with the liver being highly susceptible due to its central metabolic role. To determine whether hepatic alterations represent transient stress or sustained remodeling, we performed an integrated multi-omics analysis in a rat model simulating chronic space radiation and microgravity. Herein, we applied an integrated multi-omics and AI-driven analytical framework combining histopathology, cytokine and miRNA profiling, proteomics, metabolomics and Western blot validation. After 21 days of simulated space conditions, rats exhibited significant hepatic atrophy, histopathological injury, and metabolic dysfunction resembling a NAFLD-like phenotype, accompanied by multi-omics signatures of impaired oxidative phosphorylation, disrupted TCA cycle activity, altered lipid-metabolic regulation, and inflammatory remodeling. During a 14-day recovery phase, hepatic atrophy and histological lesions were incompletely improved, with omics changes suggesting partial restoration of mitochondrial related energy metabolism, PPAR associated lipid regulation, and fatty acid β-oxidation. Machine learning-based proteomics identified a panel of energy-related and lipid-metabolic proteins that robustly distinguished injury from recovery states. External validation with NASA GeneLab transcriptomic datasets supported the suppression of extracellular matrix programs and structural repair during injury. Together, these findings organize the hepatic response to simulated spaceflight into (1) AMPK/PPAR-γ/PGC-1α-centered energy-related lipid/mitochondrial regulation, (2) ACSM5/CRAT-associated fatty-acid utilization and carnitine-shuttle remodeling, and (3) TGF-β/IGF1-related structural repair and anabolic signaling. This study provides a comprehensive organ-level overview for understanding hepatic adaptation to extreme spaceflight environments and identifies potential targets for mitigating astronaut health risks during long-duration missions. - Source: PubMed
Zhang HanLi BoyangZou YufanYao FengSu WeijunLi Bo - Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer and remains associated with poor prognosis despite therapeutic advances. Protein palmitoylation, particularly reversible S-palmitoylation, modulates oncogenic signaling, membrane localization, and immune checkpoint stability, but the prognostic landscape of palmitoylation-related genes (PRGs) in LUAD and their relationship with the tumor microenvironment are not well defined. - Source: PubMed
Publication date: 2026/04/29
Wu ChaopengWang JinsongLiu YihanNi ZihanZhan YujieFeng WanyingFeng JiaPeng Min - Beef flavor is a trait difficult to evaluate since different senses (taste, touch, and smell) are involved in its perception. In the last 20 years, 102 Quantitative Trait Loci (QTLs), associated with the variability of different beef flavor notes, have been reported. These QTLs are spread on all chromosomes, including BTA X. In these QTL regions, 2509 genes are located and, among them, 594 are involved in the metabolic processes of lipids, proteins, and carbohydrates, the main meat components for the production of volatile substances responsible for flavor. Only 19 of these genes (, , , , , , , , , , , , , , , , , , and ) are also present in the QTL regions affecting pork flavor. The applied approach allowed us to strongly restrict the number of candidate genes to affect the variability of both beef and pork flavor. - Source: PubMed
Publication date: 2026/03/25
Rando AndreaGrassi GiuliaPerna Anna MariaDi Gregorio Paola - The aim of the present study is to compare cold adaptation mechanisms between cold-tolerant Hezuo and cold-sensitive Bama pigs. - Source: PubMed
Publication date: 2026/03/11
Li YajuanGao XiaoliZhang YatingGun Shuangbao - Lung cancer has a high incidence rate, and immunotherapy is only effective for a subset of patients. This study aimed to develop a signature associated with immunotherapy response to accurately predict the prognosis of non-small cell lung cancer (NSCLC) patients and assess immunotherapy efficacy. Such efforts are crucial to address the therapeutic challenges faced by patients with advanced lung cancer. - Source: PubMed
Publication date: 2026/01/27
Ma XiaofeiDu WeijiaoBai MingDai Zhenbo