ACSM4
- Known as:
- ACSM4
- Catalog number:
- 001054A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACSM4
Related genes to: ACSM4
- Gene:
- ACSM4 NIH gene
- Name:
- acyl-CoA synthetase medium chain family member 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2018-05-03
Related products to: ACSM4
Related articles to: ACSM4
- Beef flavor is a trait difficult to evaluate since different senses (taste, touch, and smell) are involved in its perception. In the last 20 years, 102 Quantitative Trait Loci (QTLs), associated with the variability of different beef flavor notes, have been reported. These QTLs are spread on all chromosomes, including BTA X. In these QTL regions, 2509 genes are located and, among them, 594 are involved in the metabolic processes of lipids, proteins, and carbohydrates, the main meat components for the production of volatile substances responsible for flavor. Only 19 of these genes (, , , , , , , , , , , , , , , , , , and ) are also present in the QTL regions affecting pork flavor. The applied approach allowed us to strongly restrict the number of candidate genes to affect the variability of both beef and pork flavor. - Source: PubMed
Publication date: 2026/03/25
Rando AndreaGrassi GiuliaPerna Anna MariaDi Gregorio Paola - The absence of a robust risk stratification tool for triple negative breast cancer (TNBC) underlies imprecise and nonselective treatment of these patients with cytotoxic chemotherapy. This study aimed to interrogate transcriptomes of TNBC resected samples using next generation sequencing to identify novel biomarkers associated with disease outcomes. A subset of cases (n = 112) from a large, well-characterized cohort of primary TNBC (n = 333) were subjected to RNA-sequencing. Reads were aligned to the human reference genome (GRCH38.83) using the STAR aligner and gene expression quantified using HTSEQ. We identified genes associated with distant metastasis-free survival and breast cancer-specific survival by applying supervised artificial neural network analysis with gene selection to the RNA-sequencing data. The prognostic ability of these genes was validated using the Breast Cancer Gene-Expression Miner v4. 0 and Genotype 2 outcome datasets. Multivariate Cox regression analysis identified a prognostic gene signature that was independently associated with poor prognosis. Finally, we corroborated our results from the two-gene prognostic signature by their protein expression using immunohistochemistry. Artificial neural network identified two gene panels that strongly predicted distant metastasis-free survival and breast cancer-specific survival. Univariate Cox regression analysis of 21 genes common to both panels revealed that the expression level of eight genes was independently associated with poor prognosis (p < 0.05). Adjusting for clinicopathological factors including patient's age, grade, nodal stage, tumor size, and lymphovascular invasion using multivariate Cox regression analysis yielded a two-gene prognostic signature (ACSM4 and SPDYC), which was associated with poor prognosis (p < 0.05) independent of other prognostic variables. We validated the protein expression of these two genes, and it was significantly associated with patient outcome in both independent and combined manner (p < 0.05). Our study identifies a prognostic gene signature that can predict prognosis in TNBC patients and could potentially be used to guide the clinical management of TNBC patients. - Source: PubMed
Publication date: 2020/05/13
Alsaleem Mansour ABall GrahamToss Michael SRaafat SaraAleskandarany MohammedJoseph ChitraOgden AngelaBhattarai ShristiRida Padmashree C GKhani FrancescaDavis MelissaElemento OlivierAneja RituEllis Ian OGreen AndrewMongan Nigel PRakha Emad - Lipid expression is increased in the atrial myocytes of mitral regurgitation (MR) patients. This study aimed to investigate key regulatory genes and mechanisms of atrial lipotoxic myopathy in MR. - Source: PubMed
Publication date: 2018/12/18
Fang Chih-YuanChen Mien-ChengChang Tzu-HaoWu Chia-ChenChang Jen-PingHuang Hsien-DaHo Wan-ChunWang Yi-ZhenPan Kuo-LiLin Yu-ShengHuang Yao-KuangChen Chien-JenLee Wei-Chieh - : Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression. - Source: PubMed
Guzmán-Fulgencio MaríaJiménez José LJiménez-Sousa María ABellón José MGarcía-Álvarez MónicaSoriano VicenteGijón-Vidaurreta PalomaBernal-Morell EnriqueViciana PompeyoMuñoz-Fernández M ÁngelesResino Salvador - The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression. - Source: PubMed
Publication date: 2010/09/21
Hendrickson Sher LLautenberger James AChinn Leslie WeiMalasky MichaelSezgin EfeKingsley Lawrence AGoedert James JKirk Gregory DGomperts Edward DBuchbinder Susan PTroyer Jennifer LO'Brien Stephen J