ACSM3
- Known as:
- ACSM3
- Catalog number:
- 001053A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACSM3
Related genes to: ACSM3
- Gene:
- ACSM3 NIH gene
- Name:
- acyl-CoA synthetase medium chain family member 3
- Previous symbol:
- SAH
- Synonyms:
- SA
- Chromosome:
- 16p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-08-23
- Date modifiied:
- 2017-06-13
Related products to: ACSM3
Related articles to: ACSM3
- Tubulointerstitial injury exerts a key role in diabetic nephropathy (DN) development; however, its potential mechanism is still unclear. We explored the role and molecular mechanisms of RAD21 cohesin complex component (RAD21) in mitochondrial dysfunction during tubulointerstitial injury of DN. We found that RAD21 was down-regulated, but its S-palmitoylation level was up-regulated in DN. RAD21 overexpression attenuated renal tubulointerstitial injury, fibrosis and mitochondrial dysfunction in DN. In addition, zinc finger DHHC-type palmitoyltransferase8 (ZDHHC8) served as a key acetyltransferase that catalyzed RAD21 S-palmitoylation at C78 site, which led to heat shock protein member 8 (HSPA8)-mediated lysosomal degradation of RAD21. Down-regulation of RAD21 repressed the transcription and expression of ACSM3. ACSM3 deficiency abrogated the beneficial effect of RAD21 overexpression on mitochondrial dysfunction during tubulointerstitial injury in DN. In conclusion, ZDHHC8-mediated S-palmitoylation of RAD21 favored its lysosomal degradation with assistance of HSPA8, which repressed ACSM3 transcription to cause mitochondrial dysfunction, thereby accelerating DN progression. - Source: PubMed
Publication date: 2026/07/15
Chen WeiChen YinyinDuan ShaobinLi HaoGao YangZhang WeiyingLiu GuoyongWang JiayiPeng XiaofeiHe Liyu - Intestinal mucosal healing is a key indicator for evaluating therapeutic efficacy and predicting long-term prognosis in ulcerative colitis (UC). Short-chain fatty acids (SCFAs) play an important role in maintaining intestinal homeostasis and promoting mucosal repair; however, their quantitative association with UC mucosal healing has not been fully elucidated. This study aimed to investigate the association between SCFA levels and endoscopic mucosal healing in UC patients and evaluate their clinical value as predictive biomarkers. - Source: PubMed
Publication date: 2026/06/13
He Ben-QiuLai Xiang-QuanYang XueZhou Jin - The river buffalo is an economically important livestock species supplying milk and meat. However, a multi-tissue transcriptomic atlas for the key dairy river buffalo breeds, Murrah and Nili-Ravi, has not yet been established, and the lack of stable reference genes has hindered in-depth studies of their biological functions and the molecular mechanisms underlying key economic traits such as lactation. We established a multi-tissue gene expression atlas across 20 tissues and identified 717 housekeeping genes (HKGs), and and were further shown to be stable candidate reference genes under the conditions tested. We found 8368 tissue-specific genes (TSGs), predominantly enriched in the reproductive system. Exploratory analysis of mammary tissue (dry-period vs. public lactating samples, confounded by batch effects) revealed mammary-enriched hub genes including ; these findings are preliminary and require validation. Dynamic analysis across lactation stages (early, peak, mid-, late) identified candidate genes including and . Phenotypic data showed strong negative correlations between milk yield and protein/fat content, and a positive correlation with lactose content. However, causal or regulatory roles were not inferred due to lack of paired individual-level data. Cross-dataset comparisons are descriptive only, and are not key conclusions. In summary, this study lays the foundation for advancing research in lactation trait genetics and functional genomics in river buffalo, with novel reference genes and lactation stage-specific transcriptional dynamics as its main contributions. - Source: PubMed
Publication date: 2026/04/30
Song XinhuiWang DongLuo XierQin ChaobinLi LingYang YanyanPi YifeiDeng YanfeiCui KuiqingLi ZhipengXu WeiLiu Qingyou - Beef flavor is a trait difficult to evaluate since different senses (taste, touch, and smell) are involved in its perception. In the last 20 years, 102 Quantitative Trait Loci (QTLs), associated with the variability of different beef flavor notes, have been reported. These QTLs are spread on all chromosomes, including BTA X. In these QTL regions, 2509 genes are located and, among them, 594 are involved in the metabolic processes of lipids, proteins, and carbohydrates, the main meat components for the production of volatile substances responsible for flavor. Only 19 of these genes (, , , , , , , , , , , , , , , , , , and ) are also present in the QTL regions affecting pork flavor. The applied approach allowed us to strongly restrict the number of candidate genes to affect the variability of both beef and pork flavor. - Source: PubMed
Publication date: 2026/03/25
Rando AndreaGrassi GiuliaPerna Anna MariaDi Gregorio Paola - Renal tubular injury plays a critical role in the progression of lupus nephritis (LN); however, the underlying mechanisms remain poorly understood. In this study, we found that CDO1 expression was significantly positively correlated with the degree of renal tubular injury in renal tissues from LN patients. Using in vitro HK-2 and TCMK-1 cells as well as an in vivo MRL/lpr mouse model, we confirmed that knockdown of CDO1 alleviated renal tubular epithelial cell injury and lipid deposition. Mechanistic studies revealed that CDO1 inhibits lipid metabolism by negatively regulating the expression of ACSM3; notably, downregulation of ACSM3 reversed the ameliorative effects of CDO1 knockdown on lipid deposition and cellular injury. Further investigation demonstrated that ACSM3 deficiency mediates lipid deposition by inducing mitochondrial morphological abnormalities and dysfunction. In summary, this study uncovers a novel mechanism by which the CDO1-ACSM3 axis mediates renal tubular lipid deposition and injury in LN through the regulation of mitochondrial function, offering a potential therapeutic target for this disease. - Source: PubMed
Publication date: 2026/03/04
Zhang ZiboLiu JinxiLiu YunheWang LiweiLi ZekunDong YanTian YuexinMiao XinyanLiu QingjuanZhang WeiGuo HuifangXing LinglingYang LinFeng XiaojuanLiu Shuxia