ACP6
- Known as:
- ACP6
- Catalog number:
- 001033A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACP6
Related genes to: ACP6
- Gene:
- ACP6 NIH gene
- Name:
- acid phosphatase 6, lysophosphatidic
- Previous symbol:
- -
- Synonyms:
- LPAP, ACPL1
- Chromosome:
- 1q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-09
- Date modifiied:
- 2016-10-05
Related products to: ACP6
Acid phosphatase 6, lysophosphatidic,Acid phosphatase-like protein 1,ACP6,ACPL1,Homo sapiens,Human,LPAP,Lysophosphatidic acid phosphatase type 6,PACPL1,UNQ205_PRO231Acid phosphatase 6, lysophosphatidic,Acid phosphatase-like protein 1,Acp6,Acpl1,Lpap,Lysophosphatidic acid phosphatase type 6,Mouse,Mus musculus,PACPL1ACP2 Gene acid phosphatase 2, lysosomalACP6 (Human) Matched Antibody PairACP6 (Human) Recombinant Protein (P01)ACP6 / LPAP antibody Host rabbitACP6 / LPAP antibody Host rabbitACP6 293T Cell Transient Overexpression Lysate(Denatured)ACP6 293T Cell Transient Overexpression Lysate(Denatured)ACP6 3&_39;UTR Lenti-reporter-Luc VectorACP6 antibodyACP6 antibodyACP6 antibodyACP6 AntibodyACP6 Antibody Related articles to: ACP6
- Strategic engineering of natural product biosynthetic pathways through the incorporation of alternative, tunable carbon-based building blocks represents a promising approach for accessing medicinally relevant molecules. However, efforts toward this goal have been hindered by the substrate specificity of component enzymes. In type I and type II fatty acid synthases (FASs) and polyketide synthases (PKSs), the acyltransferase (AT) selects a specific malonyl-based coenzyme A (CoA) building block and transfers it onto the acyl carrier protein (ACP) for subsequent processing. Inspired by the observation that some ACPs can bypass the AT and "self-acylate", we herein explored the tolerance of FAS and PKS ACPs to load both a variety of CoA substrates and ethane thioester (ET) analogs serving as truncated CoA building blocks. We observe that the Escherichia coli (E. coli) AT, FabD, can load and transfer methylmalonyl-CoA (mm-CoA) and malonyl-CoA (m-CoA) onto three ACPs: the type II Streptomyces coelicolor actinorhodin PKS ACP (ActACP), the E. coli type II FAS ACP (AcpP), and the type I Saccharopolyspora erythraea 6-deoxyerythronolide B PKS ACP6 (DEBS ACP6). Synthesized ET analogs of mm-CoA and m-CoA were loaded onto all three ACPs through FabD-assisted acylation. Additionally, both in the presence and absence of FabD, ACPs could be acylated with ET analogs of fluoromalonyl-, succinyl-, and glutaryl- building blocks. Overall, this work pushes the limits of ACP substrate loading, revealing new complexity in carbon-based building block selection and establishing foundations for novel routes toward diverse functional group incorporation in FAS/PKS biosynthetic pathways. - Source: PubMed
Bowler Jana CThompson Anna-Lee CFreeman Colby MEllett Yarra LSeebald Leah MCharkoudian Louise K - Identification and validation of potential therapeutic targets for retinitis pigmentosa (RP). - Source: PubMed
Jia ChunyiMa TianjuJia Liang - Bladder cancer (BLCA) is a common malignant tumor of the urinary system with a poor prognosis, especially in cases of invasive or advanced patients. Although mitochondrial dysfunction is associated with tumor progression, there are relatively few mitochondrial-related prognostic models for bladder cancer. The intention of study was to construct a five-gene mitochondrial-related prognostic marker for bladder cancer, and perform external validation, and then explore its association with the tumor immune microenvironment and potential immune treatment response. - Source: PubMed
Publication date: 2026/05/15
Liu JingLi BoHou RongrongSun JialiNing XiaoleiLi ChongniLi FangZhang Lingang - The clinical phenotypes associated with 1q21.1 deletion or duplication syndromes vary considerably among individuals, and the underlying mechanisms remain poorly elucidated. Moreover, data on prenatal ultrasound findings in fetuses carrying these copy number variants are still limited. This study aimed to preliminarily evaluate the association between prenatal phenotypic features and 1q21.1 deletion/duplication syndromes. - Source: PubMed
Publication date: 2025/11/10
Luo XiaojinChen XiaohangTang YanliLiu LiXu JinmaoWu LipingPei YuanyuanLiu WeiqiangWei Fengxiang - Endometrial cancer (EC) is one of the most prevalent malignant tumors affecting women's health and well-being, with both morbidity and mortality rates increasing every year. Acid phosphatase type 6 (ACP6) is a mitochondrial lipid phosphatase that is involved in tumorigenesis and cancer progression. Although ACP6 is significantly contributing to these pathways, its specific function in EC remains poorly explored. - Source: PubMed
Publication date: 2025/06/27
Lin QinglingLiang XiaoleiMa LiangjianMa XingLi BinYang YongxiuYang Kehu