ACOX3
- Known as:
- ACOX3
- Catalog number:
- 001028A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACOX3
Related genes to: ACOX3
- Gene:
- ACOX3 NIH gene
- Name:
- acyl-CoA oxidase 3, pristanoyl
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4p16.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2016-10-05
Related products to: ACOX3
Related articles to: ACOX3
- Mito-nuclear coadaptation is a fundamental evolutionary process linking genomic interactions to metabolic performance and organismal fitness. Although mito-nuclear incompatibility is known to impair mitochondrial function and contribute to hybrid breakdown, its effects on metabolic coordination between cellular organelles remain poorly understood, particularly in insects. Here, we used the black soldier fly (Hermetia illucens L.) as an experimental model and established a mito-nuclear incompatibility system by introducing heterologous mitochondrial genomes into a common nuclear background. Integrating genomic, transcriptomic, metabolomic, and functional analyses, we found that mito-nuclear mismatch disrupted not only mitochondrial oxidative phosphorylation but also peroxisome biogenesis and fatty acid metabolism. We identified the peroxisomal acyl-CoA oxidases ACOX1 and ACOX3 as important components associated with mito-nuclear incompatibility-induced disruption of mitochondria-peroxisome metabolic coordination. Functional knockdown of ACOX genes recapitulated major metabolic and fitness-related phenotypes associated with mito-nuclear mismatch, including energy deficiency, oxidative stress, delayed larval development, and reduced adult reproductive performance. Moreover, restoration of redox and energetic homeostasis partially rescued ACOX expression, whereas reinstating ACOX expression alleviated lipid metabolic defects in mismatched lines. Together, these findings support a model in which mito-nuclear incompatibility disrupts mitochondrial function and peroxisomal metabolic homeostasis, with reduced ACOX-dependent fatty acid metabolism representing an important component of broader mitochondria-peroxisome metabolic dysregulation. Our findings reveal a previously underappreciated role of mito-nuclear interactions in coordinating mitochondrial-peroxisomal metabolism and provide a mechanistic framework for understanding how genomic compatibility influences metabolic integration across cellular organelles. - Source: PubMed
Publication date: 2026/09/21
Wang XueZhao ShuyunHuang GuoxinWang RunjiaRen XinruiLiu JingHuang JunkuiXiao Jinhua - To investigate the mechanisms underlying benzo[a]pyrene-induced esophageal cancer (EC), and to screen and identify the key targets and biomarkers associated with benzo[a]pyrene-related EC. - Source: PubMed
Publication date: 2026/07/15
Lan XuyanHuang ZuqiangLin YukunSun XiaoyuGuo BinghanLi GenglinWang JintaoLin JinlanZhu LihuanGuo Tianxing - This study investigated the potential effects of Bellamya purificata polysaccharide (BPP) supplementation in feed on , aiming to elucidate its impact on immune function and the underlying regulatory mechanisms. A 60-day feeding trial was conducted to evaluate the effects of varying dietary BPP concentrations (0‱, 2‱, 4‱, 6‱, and 8‱) on growth performance, histopathology, immune function, and transcriptomic profiles of . Dietary BPP significantly increased the final body length and body weight of . Furthermore, BPP inclusion improved the histological damage of hepatopancreatic tissues, alleviated physiological stress, and enhanced antioxidant capacity, antibacterial activity, and anti-inflammatory function, as evidenced by alterations in relevant enzyme activities and gene expression levels. Transcriptomic analysis revealed 957 differentially expressed genes (DEGs), which were predominantly enriched in GO terms and KEGG pathways associated with BPP-mediated immune regulation, such as the PPAR signaling pathway, peroxisome, steroid hormone biosynthesis, and lysosome. In addition, 14 candidate genes were identified, including , , , and . Integrated analysis of GO, KEGG, and Short Time-Series Expression Miner (STEM) data supported the development of a mechanistic model illustrating how modulates immune function in response to BPP supplementation. RT-qPCR validation confirmed the accuracy and reliability of the high-throughput sequencing results. Collectively, these findings highlight the potential of BPP as a functional feed additive in aquaculture and provide novel insights into disease prevention strategies for the farming industry. - Source: PubMed
Publication date: 2026/07/22
Yuan ChangYang HuizanPan XianhuiLin YongZhou KangqiLin FengChen WenjianLi YusenHan YaoquanWei HuiWang CaiguangHuang LiangliangWang Dapeng - Acute kidney injury (AKI) is a life‑threatening condition with limited preventive medications. While the transcription factor Krüppel-like factor 4 (KLF4) is critical to AKI pathophysiology, its underlying molecular mechanisms remain incompletely understood. This study investigates KLF4 from a metabolic perspective and explores the renoprotective potential of doxycycline, an FDA-approved antibiotic. In murine models of ischemia‑reperfusion (IR)‑ and cisplatin (CDDP)‑induced AKI, doxycycline administered significantly attenuated kidney injury and protected renal tubular cells from glucose deprivation- and oxygen‑glucose deprivation-induced stress in vitro. Integrative transcriptomic and metabolomic profiling revealed that AKI progression involves profound metabolic dysfunction, characterized by the downregulation of peroxisomal Acyl-CoA oxidase 3 (ACOX3) and mitochondrial Isocitrate dehydrogenase 2 (IDH2). We identified KLF4 as a dual transcriptional repressor of ACOX3 and IDH2. Mechanistically, molecular docking, surface plasmon resonance, and co-immunoprecipitation assays demonstrated that doxycycline directly binds KLF4 and promotes its ubiquitin-mediated degradation via the E3 ligase FBXO32, which restores ACOX3/IDH2-mediated fatty acid oxidation and the TCA cycle, enhancing cellular resilience against ischemic crisis. These findings define a novel KLF4‑ACOX3/IDH2 metabolic axis and highlight doxycycline as a promising repositioning candidate for AKI prevention. - Source: PubMed
Publication date: 2026/07/24
Feng JiYao Zhi-ShengLi Yu-HongBai YanHu JunQi Cao-YanChen Zi-YiLiu Yue-TongXue KunZhou JingLu Guo-Dong - The aquaculture industry increasingly adopts palm oil (PO) as a sustainable alternative to fish oil (FO). However, whether this substitution induces adverse physiological responses under low-salinity stress remains poorly understood, especially for estuarine species. This study investigated the effects of long-term (10 weeks) dietary intake of FO and PO on growth, osmoregulation, mitochondrial function, lipid and energy metabolism, endoplasmic reticulum stress (ERS), and metabolomics in Scylla paramamosain under normal salinity (25‰, NS) and low salinity (6‰, LS). The results showed that crabs in the LS-PO group had significantly reduced percent weight gain compared to those in the LS-FO group. Additionally, LS-PO crabs demonstrated elevated hemolymph and posterior gill apoptosis, accompanied by severe gill structural damage and mitochondrial impairment in antennal glands. Osmoregulatory capacity was further compromised, as evidenced by decreased activities of Na⁺/K⁺-ATPase, V-ATPase, and CA compared to NS-FO and LS-FO groups. Mitochondrial dysfunction was indicated by reduced membrane potential, elevated ROS and MPTP, decreased SDH and ATP contents in the gills, and impaired mitochondrial respiratory chain complexes I-IV related genes expression in both posterior gills and hepatopancreas (nduf6, cox1, cyc1). PO further exacerbated the expression of ERS-related proteins (Grp78, P-Perk, Atf4, P-Ire1) in the hepatopancreas under low salinity. Hepatopancreatic lipid dysregulation was aggravated in LS-PO crabs, characterized by accumulated lipid droplets and downregulated expression of cpt1, hsl, acox1, and acox3. Notably, LS-PO crabs accumulated long-chain acylcarnitines and exhibited depletion of TCA intermediates (α-ketoglutarate), indicating severe suppression of mitochondrial β-oxidation. Correlation and interaction network analyses identified phosphorylcholine, glycerophosphocholine, na/k-atpase, hspa5, pelle, and relish as potential hub nodes. These findings indicate that, under the tested low-salinity conditions, dietary palm oil was less effective than fish oil in supporting osmoregulatory and metabolic homeostasis in Scylla paramamosain, highlighting the need to consider dietary lipid source when formulating feeds for low-salinity mud crab aquaculture. - Source: PubMed
Publication date: 2026/07/13
Xu TiantianLi XiaoyueDeng YaoXie ShichaoZhan WenhaoCui XishuaiJin MinZhou Qicun