ACHE
- Known as:
- ACHE
- Catalog number:
- 001007A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACHE
Related genes to: ACHE
- Gene:
- ACHE NIH gene
- Name:
- acetylcholinesterase (Cartwright blood group)
- Previous symbol:
- YT
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-02
- Date modifiied:
- 2019-04-23
Related products to: ACHE
Related articles to: ACHE
- Network meta-analyses (NMAs) frequently inform recommendations for osteoarthritis (OA), but methodological flaws may introduce bias and yield misleading results. This methodological study aimed to evaluate the risk of bias in a restricted sample of systematic reviews incorporating NMAs of health care interventions for knee and hip OA. - Source: PubMed
Publication date: 2026/09/06
Schleimer TimKaczorowski SvenjaTeichert FlorianDias SofiaEhrenbrusthoff KatjaHolden MelanieLunny CaroleSaueressig TobiasHenriksen MariusBelavy Daniel L - Cancer neuroscience has expanded the conceptual landscape of tumor biology by revealing that nerves are not passive bystanders within malignant tissues, but active regulators of tumor progression, immune surveillance, and therapeutic response. Among neural components of the tumor microenvironment, nociceptive sensory neurons have emerged as critical interfaces between tissue injury, inflammation, cancer-associated pain, and immune regulation. This review proposes that nociceptive neuron-driven immune escape represents a tissue-level pathological process positioned at the intersection of cancer neuroscience, tumor immunology, and immunometabolism. We discuss how tumor-associated inflammatory mediators, extracellular acidosis, mechanical stress, metabolic perturbations, and axon-guidance programs activate nociceptors and induce the release of calcitonin gene-related peptide (CGRP) and related neuropeptides. Through receptor activity-modifying protein 1-containing receptor complexes, CGRP can suppress CD8⁺ T-cell receptor signaling, promote exhaustion-associated transcriptional and metabolic programs, impair dendritic cell function, and reinforce suppressive myeloid and regulatory immune compartments. We further examine how tumor cells may co-opt the ATF4-SLIT2-CGRP axis to establish cross-organ neuroimmune circuits extending to tumor-draining lymph nodes, thereby weakening antigen presentation, T-cell priming, and responsiveness to immune checkpoint blockade. Finally, we consider lactate accumulation and extracellular acidification as parallel immunometabolic pressures that may consolidate nociceptor-associated immune dysfunction by constraining T-cell bioenergetic fitness, promoting suppressive immune states, and potentially modulating sensory-neuron activity. Rather than defining a fixed linear pathway, we conceptualize the nociceptor-CGRP-lactate axis as an integrative neuroimmune-metabolic framework in which partially independent neural and metabolic processes converge on shared mechanisms of immune escape. This framework provides a translational rationale for evaluating combined neural, metabolic, and immune checkpoint-directed interventions in cancers characterized by neural involvement, metabolic suppression, and immunotherapy resistance. - Source: PubMed
Publication date: 2026/09/06
Zhao Peng-YuWu KunJin Zi-XiangLi Xu-ZhaoJin Wei-LinRozpędek-Kamińska Wioletta - - Source: PubMed
Publication date: 2026/09/06
Nagamine Takahiko - To evaluate the clinical outcomes of vaginal natural orifice transluminal endoscopic surgery (vNOTES) compared with conventional minimally invasive surgery (MIS), including multiport laparoscopy and laparoendoscopic single-site surgery (LESS), in benign gynecologic procedures. - Source: PubMed
Publication date: 2026/09/06
Dinoi GiorgiaMastrovito SaraTarantino VincenzoRiccetti CamillaArrigo DavideParadisi GiancarloCarcagni AntonellaGiannarelli DianaFagotti AnnaFanfani FrancescoPanico Giovanni - Chest pain is one of the most common reasons for visits to the Emergency Department (ED) worldwide. Effective risk stratification tools are essential for distinguishing between life-threatening cardiac events and non-cardiac causes. The HEART score is a widely used clinical decision tool designed to assist in this process. This review aims to synthesise the evidence on healthcare practitioners' use of the HEART score for risk stratification and management of adults with acute chest pain presenting to the ED. - Source: PubMed
Publication date: 2026/09/06
Grady Mary O'Lloyd Barbara