ACER3
- Known as:
- ACER3
- Catalog number:
- 001006A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACER3
Related genes to: ACER3
- Gene:
- ACER3 NIH gene
- Name:
- alkaline ceramidase 3
- Previous symbol:
- PHCA
- Synonyms:
- FLJ11238, APHC
- Chromosome:
- 11q13.5
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-03
- Date modifiied:
- 2015-07-28
Related products to: ACER3
Related articles to: ACER3
- Myopia is one of the most common eye diseases affecting children and adolescents, with its etiology often attributed to a combination of genetic and environmental factors. This study utilized single-cell RNA sequencing (scRNA-seq) technology to investigate gene expression differences between guinea pigs with spontaneous high myopia (SHM) and those with normal vision. - Source: PubMed
Publication date: 2026/07/02
Bao BoLiu JinpengXie YunxiaoXi RuofanSun YuecongYan JingzheXin JizhaoYang ZhaohuiYin XueweiGuo DadongBi Hongsheng - Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinating this transition across multiple biological layers remain incompletely understood. Here we present the first simultaneous five-layer multi-omics characterization of mESC-derived adipocyte differentiation, integrating transcriptomics, proteomics, secretomics, lipidomics, and metabolomics from matched adipogenic (Pos) and non-differentiating (Neg) cell populations at day 30. Applying Multi-Omics Factor Analysis (MOFA+), we identified a dominant shared latent axis that perfectly segregated Pos from Neg cells across all five views. Layer-specific functional enrichment converged on two principal biological axes: ECM remodeling - encompassing collagens, laminins, thrombospondins, and lysyl oxidases - and lipid metabolic reprogramming, with phospholipid and glycerolipid metabolic processes dominating the lipidomics/metabolomics layer. Ensemble Machine Learning Feature Ranking (EMFR) identified a secreted factor (Scpep1; importance score 0.90) as the top-ranked discriminatory feature. Network analysis revealed indirect ECM-lipid connectivity mediated by four bridging nodes (Plod1, Thbs2, Plg, Pmp22) through a hub subnetwork of phospholipid-metabolizing enzymes. Targeted qPCR validation of six candidate regulators (Itga5, Igfbp6, Pik3cg, Lpl, Acer3, Sirt1) confirmed RNA-seq concordance. These findings establish convergent ECM remodeling and lipid metabolic reprogramming as central axes of adipocyte identity acquisition from mESCs. - Source: PubMed
Publication date: 2026/06/02
Al-Sayegh MKhalili MAlzaabi MSultana MAli LAli MEl-Hadidi M - Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy with a poor prognosis, characterized by dedifferentiation and aberrant angiogenesis. Through integrated analysis of TCGA and GEO transcriptomic data and single-cell RNA sequencing, this study identified significant enrichment of angiogenesis-related genes (ARGs), particularly sphingosine kinase 1 (SPHK1), in malignant cell subpopulations of ATC. Functional investigations revealed that alkaline ceramidase 3 (ACER3) cooperates with SPHK1 within the sphingolipid metabolic pathway to promote ATC progression. The SPHK1-specific inhibitor PF543 suppresses the activity of this key protein, thereby exhibiting potential therapeutic effects. To address the poor aqueous solubility and limited targeting ability of PF543, we constructed biomimetic nanoparticles (CMOE@PLGA@PF543) coated with S1PR1-overexpressing cancer cell membranes (CMOE), enabling tumor-specific targeting through the sphingosine-1-phosphate (S1P) and sphingosine-1-phosphate receptor 1 (S1PR1) ligand-receptor interaction. In vitro, PF543 downregulated SPHK1 expression and induced apoptosis in ATC cells. In vivo, CMOE@PLGA@PF543 exhibited enhanced tumor-targeting accumulation, excellent biosafety, and potent inhibition of tumor growth by suppressing the ACER3/SPHK1/S1P axis. These findings reveal a novel molecular mechanism driving ATC progression and offer a targeted nanotherapeutic strategy with strong potential for clinical translation. - Source: PubMed
Publication date: 2026/05/11
Bai YangChen JiaqiLin HaipingMa WeikeZhu MengtingZhang YuxiangDuan YantingXu JiajieGe Minghua - Coffin-Siris syndrome (CSS) is predominantly attributed to variants in ARID1B gene, however, the molecular pathways connecting ARID1B to myelination and neural development are not well elucidated. - Source: PubMed
Publication date: 2026/04/10
Yang XingkunGan ZhongzhiZhou YasiZhang MingmingWu ShuijuanHe FeiShen ZongruiMa ShunfeiSu XiXiong Fu - Calf health is becoming an increasingly important consideration for genetic selection in modern dairy cattle. However, the impact of calf diseases on other economically important traits and the genetic architecture underlying these traits remain poorly understood. This study aimed to (1) determine the impact of including calf disease traits into Canadian national genetic evaluation by estimating genetic and phenotypic correlations with other economically important traits, and (2) conduct a GWAS and functional analysis to identify and understand genomic regions associated with calf disease traits in the Holstein breed. The majority of genetic correlation estimates between calf diseases and other economically important traits were close to zero. However, notable correlations were found between respiratory problems and both fertility traits and clinical mastitis, which showed a favorable relationship. Similarly, estimated phenotypic correlations were generally small, suggesting limited phenotypic impact of calf disease on later life performance. These results highlight the importance of including calf disease traits within national evaluations to ensure improvements can be made on the genetic level. From the GWAS, 17 SNPs across 5 chromosomes were significantly associated with diarrhea, and 20 SNPs across 5 chromosomes were significantly associated with respiratory problems. The enrichment analysis revealed 7 candidate genes that were colocalized with the SNP significantly associated with diarrhea (ACER3, CAPN5, ILK, LIPT2, PGM2L1, PPME1, and TNP2). For respiratory problems, the enrichment analysis revealed 4 candidate genes that were colocalized with the significant SNP (SYNPO, DCTN4, ANXA6, and MYOZ3). Several potential candidate genes were identified, although further work is required to determine the exact association between identified genes and calf disease traits. - Source: PubMed
Publication date: 2026/04/03
Lynch CMakanjuola B OSchenkel F SMiglior FKelton DBaes C F