ACCS
- Known as:
- ACCS
- Catalog number:
- 000999A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACCS
Related genes to: ACCS
- Gene:
- ACCS NIH gene
- Name:
- 1-aminocyclopropane-1-carboxylate synthase homolog (inactive)
- Previous symbol:
- -
- Synonyms:
- PHACS, ACS
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-01-25
- Date modifiied:
- 2018-06-26
Related products to: ACCS
Related articles to: ACCS
- Clubroot, caused by Plasmodiophora brassicae, poses a serious threat to the rapeseed (Brassica napus) industry. Due to B. napus being an allopolyploid with a complex genome and the current scarcity of available resistance gene resources, the molecular basis of rapeseed resistance to P. brassicae remains poorly understood. Here, we performed a functional characterization of BnEIN2 (ethylene-insensitive protein) to explore the role of ethylene signaling in rapeseed resistance to P. brassicae. The Bnein2 mutants generated through CRISPR/Cas9 technology exhibited enhanced resistance to P. brassicae, along with reduced 1-aminocyclopropane-1-carboxylic acid (ACC)/S-adenosyl-L-methionine (SAM) accumulation and ethylene insensitivity. Pharmacological assays demonstrated that inhibitors of ethylene biosynthesis or signaling improved the resistance of Bnein2 mutant plants to P. brassicae. Transcriptome analysis revealed that loss-of-function of BnEIN2 affected the expression of ethylene-, auxin-, and cytokinin-related genes. Moreover, the increased resistance of Bnein2 mutants to P. brassicae was accompanied by a reduction in auxin (indole-3-acetic acid, IAA) biosynthesis and degradation of cytokinin (trans-zeatin, TZ). Collectively, these findings establish the negative regulatory role of ethylene signaling in rapeseed resistance to P. brassicae. This study represents the first effort to elucidate rapeseed resistance to P. brassicae by directly obtaining rapeseed genetic material and offer novel insights into the hormonal regulatory network underlying disease resistance and valuable resources for breeding clubroot-resistant varieties. - Source: PubMed
Publication date: 2026/09/11
Chen JiaoZhang DandanLiu YingjunJin PinyuanZhang HongyunLuo ShengZhang Huajian - Anxiety is an adaptive response essential for survival that integrates external stimuli, internal states, memory, and decision making to respond to perceived threats. When dysregulated, it can become excessive and persistent, contributing to psychiatric and neurological disorders. The anterior cingulate cortex (ACC) integrates cognitive, emotional, interoceptive, and autonomic information and serves as a key hub in anxiety-related circuits. However, its subregion- and pathway-specific roles remain incompletely integrated across species. This review examines the cytoarchitectural and cellular organization of ACC subregions and their proposed correspondence in humans, non-human primates, and rodents. We then review ACC connectivity with the amygdala, hippocampus, insula, and bed nucleus of the stria terminalis and propose an integrative model in which ACC effects depend on subregion, projection target, and behavioral context. We also summarize structural, functional, connectivity, and neurochemical alterations of the ACC in anxiety-related disorders and neurodegenerative diseases with prominent anxiety symptoms. Finally, we discuss the strengths and limitations of rodent and non-human-primate models and identify priorities for future mechanistic and translational studies. Together, this review provides a timely and comprehensive view of the ACC's role in adaptive and pathological anxiety and offers a framework for advancing mechanistic and translational research. - Source: PubMed
Publication date: 2026/08/26
Dew EmilyJones AlexisSaggu ShaliniPozzo-Miller LucasWang Qin - Mitotane is e first-line medical treatment for adrenocortical carcinoma (ACC). Mitotane has substantial dr awbacks, including severe toxicity and contralateral gland destruction, whilst effective in only 25-30% of ACCs. To improve patient selection for mitotane therapy, this study aimed to identify tissue biomarkers associated with in vitro mitotane response. - Source: PubMed
Publication date: 2026/09/09
Vietor Charlotte LIyer Anand Mvan Koetsveld Peter MSwagemakers Sigrid M Avan der Spek Peter JBindels Eric M JZeneyedpour LonaLuider Theo Mvan Velthuysen Marie-Louise FAssié GuillaumeJouinot AnneHofland Johannesde Herder Wouter WVerhoef Cornelisvan Ginhoven Tessa MFeelders Richard AHofland Leo J - Adrenocortical tumors (ACTs) are rare pediatric tumors which include both benign adrenocortical adenomas (ACAs) and malignant adrenocortical carcinomas (ACCs). The most common presentations of an ACT in children are virilization and/or Cushing's syndrome resulting from tumoral secretion of androgens and cortisol, respectively. Adrenocortical tumors that express high levels of estrogen are extremely rare, and adrenal tumors that co-secrete more than one class of adrenal hormones raise concern for malignancy. - Source: PubMed
Publication date: 2026/09/05
Veera Simrat KaurShacham NitsanEpstein JessyCohen Danielle WolfeRoman ElizabethThomas Kristen MLipton MarissaKohn Brenda - The 6th edition of the WHO Classification of Digestive System Tumours distinguishes amphicrine-like carcinomas (ALCs) from mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs). Acinar cell carcinomas (ACCs) with an intimately admixed and not separated neuroendocrine component comprising >30% of the tumour are classified as amphicrine-like ACCs (AL-ACCs). We characterised the genomic landscape of pancreatic ACCs and AL-ACCs to validate current classification and identify therapeutic targets. - Source: PubMed
Publication date: 2026/09/04
Kim ChankyungYun Hyun-NamKim DeokhoonJeong Byung-KwanShin JinhoYoo ChanghoonOh DongwookKim Kyu-PyoSong Tae JunSong Ki ByungLee Seung SooKim Song CheolHong Seung-Mo