ACAT1
- Known as:
- ACAT1
- Catalog number:
- 000987A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACAT1
Related genes to: ACAT1
- Gene:
- ACAT1 NIH gene
- Name:
- acetyl-CoA acetyltransferase 1
- Previous symbol:
- ACAT
- Synonyms:
- THIL
- Chromosome:
- 11q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-12
- Date modifiied:
- 2014-11-19
Related products to: ACAT1
ACACT,ACACT1,ACAT,ACAT1,ACAT-1,Acyl-coenzyme A cholesterol acyltransferase 1,Cholesterol acyltransferase 1,Homo sapiens,Human,SOAT,SOAT1,STAT,Sterol O-acyltransferase 1ACAP2 Gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 2ACAT,ACAT1,Acetoacetyl-CoA thiolase,Acetyl-CoA acetyltransferase, mitochondrial,Homo sapiens,Human,MAT,T2acat1 antibody Isotype IgG Host RabbitACAT1 MAT antibody Ab host: RabbitACAT1 MAT antibody Ab host: RabbitACAT1 MAT (253-266) antibody Ab host: GoatACAT1 MAT (257-269) antibody Ab host: GoatACAT1 MAT (C-term) Ig antibody Ab host: RabbitACAT1 MAT (N-term) IgG antibody Ab host: MouseACAT1 MAT IgG antibody Ab host: RabbitACAT1 MAT IgG antibody Ab host: RabbitACAT1 MAT IgG antibody Ab host: RabbitACAT1 MAT IgG1 antibody Ab host: MouseACAT1 MAT IgG1 antibody Ab host: Mouse Related articles to: ACAT1
- Ionizing radiation (IR)-induced alterations in glucose metabolism are closely associated with radioresistance, yet the underlying mechanisms remain incompletely understood. Here, we identify a post-translational modification axis in which IR induces general control non-repressible protein 5 (GCN5/KAT2A)-mediated crotonylation of acetyl-CoA acetyltransferase 1 (ACAT1) at lysine 181 (K181), thereby enhancing ACAT1 activity and promoting increased acetylation of pyruvate dehydrogenase E1 subunit alpha (PDHA1) along with its phosphorylation at S293.These changes led to inhibition of PDHA1, impaired pyruvate metabolism, and increased lactate accumulation. Functional studies demonstrated that ACAT1 K181R (a decrotonylation-mimicking mutant) increased radiosensitivity and significantly attenuated IR-induced lactate production. Collectively, these findings reveal an unrecognized mechanism by which radiotherapy reprograms cellular metabolism through the GCN5-ACAT1-PDHA1 axis, linking ACAT1 crotonylation to altered pyruvate metabolism, enhanced lactate production, and subsequent radioresistance. These findings suggest that targeting ACAT1 K181 crotonylation represents a potential therapeutic strategy to improve tumor radiosensitivity. - Source: PubMed
Publication date: 2026/07/23
Chen ShiLi SaiyuGuo HejiangGao ShuainingGao YueDing LehanZhao BinZhong KunGuan HuaPeng Rui-YunZhou Ping-Kun - Cerebral ischemic stroke triggers extensive neuronal membrane breakdown, releasing a massive load of cholesterol that overwhelms resident microglia. Dysregulated microglial cholesterol metabolism has been implicated in post-stroke neuroinflammation, yet the specific pathogenic microglial subpopulations, their molecular signatures, and the downstream inflammatory cascades remain poorly defined. - Source: PubMed
Cheng YueZhou YuxiChen YonghuiShen TianniLi YanChen ChenFan QiuyueQi JieLi PeiyingZhang Yueman - Alcohol-associated liver disease (ALD) is a major cause of advanced liver disease, with limited effective clinical interventions, highlighting an urgent need for new therapeutic targets. Acyl-CoA:cholesterol acyltransferase 1 (ACAT1) is a key cholesterol-metabolizing acyltransferase that catalyzes the esterification of free cholesterol into cholesteryl esters. It is highly expressed predominantly in macrophages and participates in the regulation of macrophage functions. Nevertheless, its role and underlying mechanism in alcoholic liver injury remain largely unclear. - Source: PubMed
Publication date: 2026/07/30
Zhao XiPeng ShiyuZhong KeqingWang MingyueCao HuilingMa ShujunQi JianniWang YingchunZhu Qiang - Hypercholesterolemia has been linked to inflammation and vascular dysfunction in diabetic retinopathy (DR). Excessive cholesterol ester (CE) production in macrophages can induce increases in inflammatory and angiogenic cytokines. AcylCoA:cholesterol acyltransferase 1/Sterol O-acyltransferase 1 (ACAT1/SOAT1) is responsible for cholesterol esterification. Here we determine its role in diabetic retinopathy (DR). We hypothesized that DR-induced increases in ACAT1/SOAT1-mediated CE formation triggers retinal inflammation and injury. - Source: PubMed
Zaidi Syed Adeel HLemtalsi TahiraXu ZhiminYamamoto MaiSandow Porsche VPaladiya DhruviKoomson ObedBrooks Steven ECaldwell Robert WCaldwell Ruth BRojas Modesto A - Tumor-associated macrophages (TAMs) play a crucial role in colorectal cancer (CRC) metastasis, particularly in the establishment of the liver metastatic niche. TAMs facilitate metastasis by enabling epithelial-mesenchymal transition (EMT) and suppressing anti-tumor immunity. While their roles in primary tumors have been extensively investigated, their functions at metastatic sites remain poorly understood. In this study, we analyzed the single-cell RNA sequencing data from 46 CRC patients, encompassing 402,972 cells, to identify macrophage subsets associated with liver metastasis. A distinct population of APOC1 IFI30 TAMs was identified and found to be significantly enriched in metastatic liver lesions. Compared to primary tumors (PT), the number of APOC1 IFI30 TAMs significantly increased at liver metastatic sites after CRC cells metastasized to the liver. We employed spatial transcriptomics to validate the above conclusions. These TAMs exhibited significantly enhanced immunosuppressive capacity and cholesterol synthesis metabolism. Further investigation showed that TAMs within metastatic niches reprogram the mevalonate pathway to enhance cholesterol synthesis, characterized by upregulation of key genes such as HMGCR and ACAT1/2. These TAMs act on surrounding tumor cells by secreting cholesterol and cytokines such as TNFSF12, TGFB1, MIF and LGALS9, thereby enhancing tumor adhesion and proliferation and creating an immunosuppressive microenvironment to continuously support tumor growth. Our findings provided new insights into the complex interactions among TAMs, immune cells, and tumor cells within CRC metastatic microenvironment, highlighting potential therapeutic targets to disrupt TAMs-mediated immune evasion and metastatic progression. - Source: PubMed
Publication date: 2026/07/11
Cai ZheyouChen YibingCui LeiYao JineQiao JianghuaSun WeihongLiu HaishengYang LinhaoYang ZhuangLiu QuentinHou BenxinZou ZhengzhiLai Dongming