ACAA2
- Known as:
- ACAA2
- Catalog number:
- 000971A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACAA2
Related genes to: ACAA2
- Gene:
- ACAA2 NIH gene
- Name:
- acetyl-CoA acyltransferase 2
- Previous symbol:
- -
- Synonyms:
- DSAEC
- Chromosome:
- 18q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-28
- Date modifiied:
- 2016-10-05
Related products to: ACAA2
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- Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy characterized by high incidence and mortality rates, representing a major global health challenge. Mounting evidence indicates that metabolic reprogramming contributes substantially to tumor development by promoting cancer cell proliferation and metastasis. However, the underlying mechanisms remain incompletely understood. Acetyl-CoA acyltransferase 2 (ACAA2), a mitochondrial enzyme that catalyzes the final step of fatty acid β-oxidation, plays a key role in cellular acetyl-CoA homeostasis. While acetyl-CoA acts as a pivotal metabolic molecule involved in protein acetylation, whether ACAA2 regulates metabolic reprogramming through acetyl-CoA-mediated mitochondrial protein acetylation remains unclear. In this study, we demonstrate that ACAA2 expression is significantly downregulated in HCC tissues and correlates with poor patient prognosis. Downregulation of ACAA2 promotes HCC cell proliferation and survival without affecting invasive capacity. Mechanistically, ACAA2 downregulation reduces mitochondrial acetyl-CoA levels, thereby decreasing mitochondrial pyruvate carrier 1 (MPC1) acetylation and accelerating its proteasomal degradation, which ultimately impairs mitochondrial pyruvate transport to promote glycolysis and cell proliferation. Collectively, our findings demonstrate a critical tumor-suppressive function of ACAA2 in HCC and suggest it as a potential therapeutic target for the treatment of this malignancy. - Source: PubMed
Publication date: 2026/07/26
Liu YangWang WeifangCheng ShixiaZhang JiaxinLi JibinWu BingJing ZheXiao Tian - Craniosynostosis is defined by premature cranial suture fusion and is biologically heterogeneous. To map mitochondrial-associated signals in craniosynostosis and rank follow-up candidates, we integrated two public microarray datasets (GSE27976, GSE50796), corrected batch effects, and analyzed 14,186 shared genes using limma. This identified 798 nominal DEGs (388 upregulated and 410 downregulated), of which 19 remained significant after Benjamini-Hochberg correction. Intersecting the nominal DEG list with the MitoCarta 3.0 inventory yielded 24 mitochondrial DEGs (MitoDEGs). Complementary feature selection reduced these 24 MitoDEGs to an eight-gene panel (TMEM11, SLC25A21, GPT2, CYP27A1, MRPS30, ACAA2, GSR, and LIG3); a multigene score reached an apparent AUC of 0.806 in the integrated dataset. Correlation-based co-expression analyses linked the panel to mitochondrial translation, electron transport, amino-acid metabolism, redox control, and cell-matrix signaling. Among craniosynostosis cases, consensus clustering on the eight genes separated two molecular subtypes with distinct GSVA pathway profiles. For experimental support in a genetically defined mouse model, we profiled bilateral coronal suture complexes from Fgfr2C361Y/+ knock-in (KI) pups and WT littermates. Jess capillary immunoassay showed higher CYP27A1 abundance in KI sutures (P = 0.0276), whereas ACAA2, LIG3, MRPS30, and TMEM11 were not significant. Data-independent acquisition (DIA) proteomics identified 523 differentially abundant proteins (516 increased, 7 decreased in KI), followed by stricter-threshold reporting, sensitivity analysis, and threshold-free rank-based enrichment. MitoCarta proteins and mitochondrial pathways remained supported under these more conservative analyses. These results support mitochondria-associated transcriptomic and proteomic changes in craniosynostosis and prioritize a limited set of mitochondrial candidates for future mechanistic work. - Source: PubMed
Publication date: 2026/06/08
Zeng HanWang YuDong MiaoYue YingyingJin Xiaolei - Substantial improvements in lamb production have been achieved through genetic selection and advanced husbandry practices; however, whether flavour heterogeneity among different muscle anatomical regions is driven by region-specific metabolic and lipid regulatory patterns remains unclear. We hypothesised that distinct muscle cuts exhibit characteristic flavour profiles associated with differential amino acid composition, lipid molecules, and gene profiles. To verify this hypothesis, the muscle (LDM), front leg muscle (FLM), and hind leg muscle (HLM) of Sadumont lamb were systematically compared using integrated omics. Significant differences in amino acid composition were observed among muscles, with glycine and valine showing pronounced variation. The FLM exhibited higher levels of delicious amino acids than LDM and HLM. Volatile profiling revealed distinct aroma signatures, with hexanal predominating in LDM, 1-octen-3-ol and d-limonene characterising FLM, and octanal, nonanal, and benzaldehyde enriched in HLM. Lipidomic analysis showed that LDM was dominated by triacylglycerols, whereas FLM was enriched in phospholipids, particularly phosphatidylcholine and phosphatidylinositol, which are associated with lipid oxidation and flavour precursor generation. The HLM displayed an intermediate lipid profile with slightly elevated C22:6 and C20:5n3. Transcriptomic analysis identified 2595 differentially expressed genes, which were enriched in lipid-related pathways, including fatty acid elongation and metabolism. Notably, divergent expression of and supported differential regulation of fatty acid oxidation across muscle cuts. These findings support our hypothesis that flavour heterogeneity among muscle cuts is closely linked to cut-specific lipid components and gene expression. Additionally，these molecular markers could be utilised in precision breeding and meat quality optimisation. - Source: PubMed
Publication date: 2026/05/18
Guo TaoXing BaimingNie RuixueWang WenwenLiu NaAn XiaopingQi JingweiWang Yuan - Qilian sheep are an important indigenous Tibetan sheep breed adapted to cold and hypoxic environments. To explore hepatic nutrient metabolism in Qilian sheep, this study compared liver transcriptomic profiles between Qilian sheep and Oula sheep raised under similar natural grazing and management conditions. Six 10-month-old ewes from each breed were selected, and three high-quality liver RNA samples from each group were used for transcriptome sequencing. A total of 1640 differentially expressed genes were identified using the thresholds of |log2FoldChange| > 1 and false discovery rate < 0.05, including 922 upregulated and 718 downregulated genes in Qilian sheep compared with Oula sheep. KEGG enrichment analysis showed that these genes were mainly associated with lipid metabolism, amino acid metabolism, the PPAR signaling pathway, fatty acid biosynthesis, and fatty acid β-oxidation. qRT-PCR validation confirmed the differential expression of 11 candidate genes, including , , , , , , , , , , and . These results suggest that Qilian sheep and Oula sheep differ in hepatic gene expression patterns related to lipid utilization, amino acid metabolism, and energy regulation, providing candidate genes and pathways for understanding breed-associated hepatic metabolic characteristics. - Source: PubMed
Publication date: 2026/05/15
Ren YaxiongAn Qi-TalaDu XiaohuaLiu XiaGao FanhongLi YuanXu YingYao LiangweiLi Wenhao - Despite established links between mitochondrial (mt) function, programmed cell death (PCD) dysregulation, and cervical cancer progression, the prognostic potential of integrating PCD- with mitochondria-related genes remains elusive. To address this gap, this study aims to develop a reliable RiskScore model leveraging PCD and mt characteristics for cervical cancer prognostic prediction. - Source: PubMed
Publication date: 2026/03/27
Cao LipingZhang Chi