ABT1
- Known as:
- ABT1
- Catalog number:
- 000967A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABT1
Related genes to: ABT1
- Gene:
- ABT1 NIH gene
- Name:
- activator of basal transcription 1
- Previous symbol:
- -
- Synonyms:
- Esf2
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-23
- Date modifiied:
- 2017-05-26
Related products to: ABT1
Related articles to: ABT1
- Lung cancer remains a major cause of cancer-related mortality, and reliable molecular targets with therapeutic relevance are still needed. This study aimed to identify key genes associated with lung cancer progression and explore the potential regulatory effect of resveratrol. The GSE43458 dataset, including 80 lung cancer samples and 30 control samples, was used for differential expression analysis and weighted gene co-expression network analysis (WGCNA). Intersecting genes were subjected to protein-protein interaction network construction, Cytoscape-based hub gene screening, functional enrichment analysis, and immune infiltration analysis. Single-cell RNA sequencing data from GSE131907 were further analyzed to characterize cellular heterogeneity and hub gene distribution. Resveratrol was predicted as a candidate compound, followed by molecular docking with hub proteins. Finally, CCK-8, Western blotting, and qRT-PCR assays were performed in BEAS-2B and A549 cells. A total of 1,655 differentially expressed genes were identified, and WGCNA identified the 252-gene turquoise module as the module most strongly associated with the lung cancer phenotype (r = - 0.86, P = 6.0 × 10⁻³⁵). Intersection analysis yielded 250 candidate genes, representing 15.1% of all differentially expressed genes. Five hub genes, CASP3, DDX54, TP53BP1, CDKN2A, and ABT1, were identified and showed significantly increased expression in lung cancer tissues (P < 0.05). Functional enrichment analysis linked the candidate genes to apoptosis, cell-cycle regulation, DNA damage repair, immune responses, and cancer-related pathways, while immune infiltration and single-cell analyses revealed marked remodeling of immune and stromal components. Molecular docking predicted potential interactions between resveratrol and the five hub proteins, with the most favorable docking scores observed for TP53BP1 (- 7.0 kcal/mol) and DDX54 (- 6.9 kcal/mol). In vitro validation further showed that resveratrol treatment significantly reduced the mRNA and protein expression of the identified hub genes in A549 cells (P < 0.05). This study identified five lung cancer-associated hub genes and provided preliminary evidence that resveratrol may modulate their expression. These findings provide a multi-level molecular framework for further investigation of resveratrol-responsive networks in lung cancer. - Source: PubMed
Publication date: 2026/08/14
Yang JinghuaWei HanxiuLi JieChen Jun - Photopharmacology provides a strategy for green pesticide design. Starting from tolfenpyrad, azobenzene-modified photochromic ligands were synthesized. showed high bioactivity and photoisomerization efficiency but limited / activity difference. To enhance this, terminal phenyl modifications yielded , which displayed amplified photoregulatory activity differences across pests. Notably, exhibited a 4.8-fold photoinduced activity enhancement against larvae and a 6.6-fold photoinduced activity reduction against , while achieved a 35-fold reduction against . Molecular docking and binding free energy calculations indicated stronger -isomer binding to the target via multiple hydrogen bonds. Molecular orbital analysis revealed a minimal HOMO-LUMO gap difference (0.05 eV) between isomers, suggesting activity differences arise from conformational changes in charge distribution rather than energy variations. This work demonstrates a rational design approach for high-performance photoresponsive pesticides. - Source: PubMed
Publication date: 2026/07/02
Zhang YongchaoQiao ZhiZhou CuncunYin QiShi LeiLi ZhongFu WenShao Xusheng - Lian is an important native tree species in the "One River, Two Streams" valley of Tibet, valued for its ecological restoration potential and nutrient-rich fruits. However, this species has several limitations, including a long fruiting cycle (3-5 years to flowering and 10-15 years to reach peak fruit production), small fruit size, and numerous branch thorns. These traits hinder large-scale cultivation and mechanized harvesting, creating an urgent need for improved varieties with larger fruit and higher yield. In this study, we established an efficient -mediated genetic transformation system for using hypocotyls as explants. Under optimized conditions (OD = 0.5, AS = 200 μmol/L, infection time = 15 min), the transformation efficiency reached 36.67% (calculated as the number of PCR-positive plants divided by the total number of explants initially inoculated with ). A rooting rate of 12.5% was achieved using 100 mg/L rooting powder (ABT1) for 40 min, resulting in an overall success rate of approximately 4-5%. Furthermore, we identified and cloned two fruit-size-related genes, and , from . Heterologous expression of and in tomato decreased and increased fruit size, respectively, consistent with their regulatory roles in fruit development. Given the positive regulatory effect of , this gene was further transformed into . This study represents the first report of a stable genetic transformation platform for , providing a robust technical foundation for future molecular breeding and the development of improved, large-fruited varieties. - Source: PubMed
Publication date: 2026/05/25
Zhang YaqingGao YumengChen ChunxiaZhao AnqiWu YunhuaShi LishaWei QixuanZhou ZijieYang XiaomingMing MeilingZhang LinCao FuliangFu Fangfang - Acinetobacter baumannii is a formidable multidrug-resistant pathogen prevalent in healthcare settings. Amid the escalating challenge of antimicrobial resistance, phage therapy has regained significant attention. This approach harnesses the natural predatory ability of bacteriophages to combat bacterial infections. - Source: PubMed
Publication date: 2026/02/26
Li XiaoxiaoLiu JiaxinLi HaoyuZhang WanlianWei HanqiSong ShihaoChen Xiangxiu - Bovine leukemia virus (BLV), a member of the Deltaretrovirus genus, causes enzootic bovine leukosis, leading to clinical outcomes that range from asymptomatic infection to malignant lymphoma. Host genetic factors significantly influence BLV susceptibility, proviral load (PVL), immune response, and disease progression. This mini-review synthesizes evidence on genetic polymorphisms in immune-related genes such as BoLA-DRB3, Tumor necrosis factor (TNF), and immunoglobulin loci, and examines novel findings from genome-wide association studies (GWAS). Beyond classical immune genes, recent GWAS have identified novel loci including SPATA16 (spermatogenesis associated 16), ABT1 (activator of basal transcription 1), IER3 (immediate early response 3), Adaptor Related Protein Complex 4 Subunit Beta 1 (AP4B1), Tripartite Motif Containing 45 (TRIM45), Patatin Like Phospholipase Domain Containing 1 (PNPLA1), and PRRC2A (proline-rich coiled-coil 2 A) that are implicated in transcriptional regulation, stress response, RNA processing, and intracellular transport, all of which may modulate viral replication and persistence. Understanding these genetic determinants provides new insights into host-virus interactions and offers opportunities for selective breeding strategies, biomarker development, and improved BLV control programs. - Source: PubMed
Publication date: 2025/11/17
Akbarin Mohammad MehdiFarjami ZahraÁlvarez Hugo Ramírez