ABHD15
- Known as:
- ABHD15
- Catalog number:
- 000952A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABHD15
Related genes to: ABHD15
- Gene:
- ABHD15 NIH gene
- Name:
- abhydrolase domain containing 15
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-04-06
- Date modifiied:
- 2016-11-09
Related products to: ABHD15
Related articles to: ABHD15
- Psoriasis, an immune-mediated systemic inflammatory disease affecting skin, vessels, and joints, often co-occurs with depression. Routine depression screening is vital, as mood disorders link to inflammation, visible lesions, and functional limitations. - Source: PubMed
Publication date: 2026/04/15
De BaojunBao WenfengHea NagongbiligeFang Jun - - Source: PubMed
Publication date: 2021/03/26
Stöckli JacquelineZadoorian ArmellaCooke Kristen CDeshpande VinitaYau BelindaHerrmann GaiaKebede Melkam AHumphrey Sean JJames David E - Myocardial infarction (MI) has been an important heart disease affecting human health. The aim of this study was to investigate the regulatory effect of abhydrolase domain containing 15 (ABHD15) on hypoxic cardiomyocytes. - Source: PubMed
Publication date: 2020/10/09
Huang GuotaoGuo XiaoliangGuo JunxiaZhang PeiyongLiang WanqianBai CaiyanZhang Yongchun - Insulin suppresses adipose tissue lipolysis after a meal, playing a key role in metabolic homeostasis. This is mediated via the kinase Akt and its substrate phosphodiesterase 3B (PDE3B). Once phosphorylated and activated, PDE3B hydrolyses cAMP leading to the inactivation of cAMP-dependent protein kinase (PKA) and suppression of lipolysis. However, several gaps have emerged in this model. Here we investigated the role of the PDE3B-interacting protein, α/β-hydrolase ABHD15 in this process. - Source: PubMed
Publication date: 2019/05/06
Stöckli JacquelineZadoorian ArmellaCooke Kristen CDeshpande VinitaYau BelindaHerrmann GaiaKebede Melkam AHumphrey Sean JJames David E - Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose treatments can suppress FA mobilization in global and conditional Abhd15-knockout (KO) mice. Accordingly, insulin signaling is impaired in Abhd15-KO adipocytes, as indicated by reduced AKT phosphorylation, glucose uptake, and de novo lipogenesis. In vitro data reveal that ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B). Accordingly, PDE3B expression is decreased in the WAT of Abhd15-KO mice, mechanistically explaining increased protein kinase A (PKA) activity, hormone-sensitive lipase (HSL) phosphorylation, and undiminished FA release upon insulin signaling. Ultimately, Abhd15-KO mice develop insulin resistance. Notably, ABHD15 expression is decreased in humans with obesity and diabetes compared to humans with obesity and normal glucose tolerance, identifying ABHD15 as a potential therapeutic target to mitigate insulin resistance. - Source: PubMed
Xia WenminPessentheiner Ariane RHofer Dina CAmor MelinaSchreiber RenateSchoiswohl GabrieleEichmann Thomas OWalenta EvelynItariu BiancaPrager GerhardHackl HubertStulnig ThomasKratky DagmarRülicke ThomasBogner-Strauss Juliane G